Tetsuya Ando, M.D., Ph.D.

Section Chief, Section of Stress Research,
Department of Psychosomatic Medicine

M.D., 1986 Kyusyu University School of Medicine.

Ph.D., 1995 Psychosomatic Medicine, Kyusyu University Graduate School of Medical Sciences.

Major Research Interests:

Biomedical and genetic studies of eating disorders

Our current research interest is to search for genes related to eating disorders (anorexia nervosa, bulimia nervosa) using candidate gene approach and also genome-wide association studies. In addition, we investigate the role of neuropeptides involved in modulation of appetite and stress responses in the pathophysiology of eating disorders. These studies will contribute to understanding of pathology of eating disorders and development of effective treatments of eating disorders.

Psychosomatic research of atopic dermatitis

Psychosocial stress is a major aggravating factor of atopic dermatitis. Impairment of quality of life and social functioning due to atopic dermatitis is often severe. We studies psychosomatic approach to prevent persistence of atopic dermatitis and to improve quality of life of the patients. Our studies have resulted in a psychosomatic clinical guideline for atopic dermatitis.

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Selected recent publications

Kikuchi H, Yoshiuchi K, Ando T, Yamamoto Y: Influence of psychological factors on acute exacerbation of tension-type headache: Investigation by ecological momentary assessment. Journal of Psychosomatic Research, 79(3): 239-242, 2015.7. [PubMed]

Kikuchi H, Yoshiuchi K, Inada S, Ando T, Yamamoto Y: Development of an ecological momentary assessment scale for appetite. BioPsychoSocial Medicine 9(1): 2, 2015.1. [PubMed]

Ando T, Tamura N, Mera T, Morita C, Takei M, Nakamoto C, Koide M, Hotta M, Naruo T, Kawai K, Nakahara T, Yamaguchi C, Nagata T, Ookuma K, Okamoto Y, Yamanaka T, Kiriike N, Ichimaru Y, Ishikawa T, Komaki G, and The Japanese Genetic Research Group For Eating Disorders: Association of the c.385C＞A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population. Molecular Genetics ＆ Genomic Medicine: 1-6, 2014.02.

Boraska V, Ando T(42/177), et al.: A genome-wide association study of anorexia nervosa: An investigation using computerized ecological momentary assessment. Mol Psychiatry, advance online publication: 1-10, 2014.02. [PubMed]

Ando T, Ishikawa T, Hotta M, et al (2012): No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese. Am J Med Genet Part B 159B:48-52. [PubMed]

Ando T, Komaki G, Nishimura H et al (2010): A ghrelin gene variant may predict crossover rate from restricting type anorexia nervosa to other phenotypes of eating disorders: a retrospective survival analysis. Psychiatric Genetics 20:153-159, 2010. [PubMed]

Nakabayashi K, Komaki G, Tajima A, Ando T, Ishikawa M, Nomoto J, Hata K, Oka A, Inoko H, Sasazuki T; Japanese Genetic Research Group for Eating Disorders (JGRED), Shirasawa S (2009): Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers. J Hum Genet 54: 531-537. [PubMed]

Nishimura H, Komaki G, Ando T et al (2008): Psychological and weight-related characteristics of patients with anorexia nervosa- restricting type who later develop bulimia nervosa. Biopsychosoc Med 2:5. [PubMed]

Ando T, Ichimaru Y, Konjiki F, Shoji M, and Komaki G (2007): Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women. Am J Clin Nutr 86: 25-32. [PubMed]

Ando T, Komaki G, Naruo T, et al (2006): Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa. Am J Med Genet Neuropsychiatr Genet 141B: 929-934. [PubMed]

Ando T, Hashiro M, Noda K, et al (2006): Development and validation of the psychosomatic scale for atopic dermatitis in adults. J Dermatol 33: 439-450. [PubMed]

Hashiro M, Ando T (2006); Atopic Dermatitis. In: Komaki G, Kubo C, Fukudo S, editors. A Guideline For the Diagnosis and Treatment of Psychosomatic Disease 2006: Kyowa Kikaku, Tokyo, pp249-280.(Japanese)

Ando T, Kodama N, Ishikawa T, et al (2004): Uncoupling protein-2/3 gene polymorphism is not associated with anorexia nervosa. Psychiatr Genet 14: 215-218. [PubMed]

Dunn A J, Ando T, Brown R F, Berg R D (2003): HPA axis activation and neurochemical responses to bacterial translocation from the gastrointestinal tract. Ann N Y Acad Sci: 992:21-29. [PubMed]

Ando T, Ishikawa T, Kawamura N, Karibe M, et al (2001): Analysis of tumor necrosis factor-α gene promoter polymorphisms in anorexia nervosa. Psychiatr Genet 11:161-164. [PubMed]

Ando T, Komaki G, Karibe M, Kawamura N, et al (2001): 5-HT2A promoter polymorphism is not associated with anorexia nervosa in Japanese patients. Psychiatr Genet11:157-160. [PubMed]

Drube J, Kawamura N, Nakamura A, Ando T, et al (2001): No leucin(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y in Japanese population or Japanese with alcoholism. Psychiatr Genet 11: 53-55, 2001. [PubMed]

Ando T, Brown RF, Berg RD, Dunn AJ (2000): Bacterial translocation can increase plasma corticosterone and brain catecholamine and indoleamine metabolism. Am J Physiol 279: R2164-R2172. [PubMed]

Ando T, Dunn AJ (1999): Mouse tumor necrosis factor-α increases brain tryptophan concentrations and norepinephrine metabolism while activating the HPA axis in mice. Neuroimmunomodulation 6: 319-329. [PubMed]

Ando T, Rivier J, Yanaihara H, Arimura A (1998): Peripheral corticotropin-releasing factor mediates the elevation of plasma IL-6 by immobilization stress in rats. Am J Physiol 275: R1461-R1467. [PubMed]

Wang J-P, Ando T, Dunn AJ (1997): Effect of homologous interleukin-1, interleukin-6 and tumor necrosis factor α on the core temperature of mice. Neuroimmunomodulation 4: 230-236. [PubMed]

Ando T, Ichijo T, Katafuchi T, Hori T (1995): Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic verve activity in rats. Am J Physiol 269: R662-R668. [PubMed]

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