2008 原著

  1. Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T: TGFBR2 gene expression and genetic association with schizophrenia. J Psychiatr Res 42(6): 425-432, 2008. Epub 2007 Jun 8.

  2. Midorikawa A, Hashimoto R, Noguchi H, Saitoh O, Kunugi H, Nakamura K: Impairment of motor dexterity in schizophrenia assessed by a novel finger movement test. Psychiatry Res 159(3): 281-289, 2008. Epub 2008 Apr 29.

  3. Ohtsuki T, Koga M, Ishiguro H, Horiuchi Y, Arai M, Niizato K, Itokawa M, Inada T, Iwata N, Iritani S, Ozaki N, Kunugi H, Ujike H, Watanabe Y, Someya T, Arinami T: A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia. Schizophr Res 101(1-3): 9-16, 2008. Epub 2008 Mar 10.

  4. Richards M, Iijima Y, Shizuno T, Kamegaya Y, Hori H, Omori M, Arima K, Saitoh O, Kunugi H: Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population. J Neural Transm 115(9): 1347-1354, 2008. Epub 2008 Aug 12.

  5. Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, Tohyama M, Yamatodani A, Kunugi H, Hashimoto R: Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem Biophys Res Comm 373(2): 298-302, 2008. Epub 2008 Jun 13.

  6. Ishiguro H, Imai K, Koga M, Horiuchi Y, Inada T, Iwata N, Ozaki N, Ujike H, Itokawa M, Kunugi H, Sasaki T, Watanabe Y, Someya T, Arinami T: Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia. Psychiatr Genet 18(5): 255-256, 2008.

  7. Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yoshimura Y, Harada N, Miyake N, Nishimura A, Saitsu H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N: Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia. J Hum Genet 53(10): 914-919, 2008. Epub 2008 Aug 7.

  8. Hori H, Nagamine M, Soshi T, Okabe S, Kim Y, Kunugi H: Schizotypal traits in healthy women predict prefrontal activation patterns during a verbal fluency task: A near-infrared spectroscopy study. Neuropsychobiology 57(1-2): 61-69, 2008. Epub 2008 May 2.

  9. Noguchi H, Hori H, Kunugi H: Schizotypal traits and cognitive function in healthy adults. Psychiatry Res 161(2): 162-169, 2008. Epub 2008 Oct 11.

  10. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Saitoh O, Murray RM, Okabe S, Kunugi H: Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI). Psychiatry Res 160(2): 175-183, 2008. Epub 2008 Jul 7.

  11. Hori H, Ozeki Y, Terada S, Kunugi H: Functional near-infrared spectroscopy reveals altered hemispheric laterality in relation to schizotypy during verbal fluency task. Prog Neuropsychopharmacol Biol Psychiatry 32(8): 1944-51, 2008. Epub 2008 Oct 1.

  12. Izumi A, Iijima Y, Noguchi H, Numakawa T, Okada T, Hori H, Kato T, Tatsumi M, Kosuga A, Kamijima K, Asada T, Arima K, Saitoh O, Shiosaka S, Kunugi H: Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions. Neuropsychopharmacology 33(13): 3237-3245, 2008. Epub 2008 Mar 19.

  13. Kazuno AA, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T: Mitochondrial DNA haplogroup analysis in patients with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2008 Jun 10. [Epub ahead of print]

  14. Hashimoto R, Moriguchi Y, Yamashita F, Mori T, Nemoto K, Okada T, Hori H, Noguchi H, Kunugi H, Ohnishi T: Dose dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. Neurosci Res 61(4): 360-367. Epub 2008 Apr 20.

  15. Hori H, Noguchi H, Hashimoto R, Okabe S, Saitoh O, Kunugi H: IQ decline and memory impairment in Japanese patients with chronic schizophrenia. Psychiatry Res 158(2): 251-255, 2008. Epub 2008 Jan 28.

  16. Kumamaru E, Numakawa T, Adachi N, Yagasaki Y, Izumi A, Niyaz M, Kudo M, Kunugi H: Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol 22(3): 546-558, 2008. Epub 2007 Dec 20.

  17. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Takeda M, Kunugi H, Koyama T: A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 32(1): 204-208, 2008. Epub 2007 Aug 19.

  18. Nunokawa A, Watanabe Y, Kitamura H, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Ozaki N, Someya T: Large-scale case-control study (and meta-analysis) of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia. Psychiatry Clin Neurosci 62(2): 239-240, 2008.

  19. Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T: TGFBR2 gene expression and genetic association with schizophrenia. J Psychiatr Res 42(6): 425-432, 2008. Epub 2007 Jun 8.

  20. Ozeki Y, Mizuguchi T, Hirabayashi N, Ogawa M, Ohmura N, Moriuchi M, Harada N, Matsumoto N, Kunugi H: A case of schizophrenia with chromosomal microdeletion of 17p11.2 containing a myelin-related gene PMP22. The Open Psychiatry Journal 2: 1-4, 2008.

  21. Kumamaru E, Numakawa T, Adachi N, Yagasaki Y, Izumi A, Niyaz M, Kudo M, Kunugi H: Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol 22(3): 546-558, 2008. Epub 2007 Dec 20.

 

2008 著書・訳書

  1. Furuta M, Kunugi H: Animal models for sdhizophrenia: a brief overview. In: Biomarkers for Psychiatric Disorders (ed. by Turck CW), Springer, New York, pp.163-184, 2008.

  2. 功刀浩監訳: 精神疾患は脳の病気か?−向精神薬の科学と虚構−. (エリオット・ S ・ヴァレンスタイン著、中塚公子訳)、みすず書房、東京、2008.

  3. 功刀浩: 治療一般. 「うつ病Q&A」(樋口輝彦編)、日本医事新報、東京、2008.

  4. 尾関祐二: 検査・診断. 「うつ病Q&A」(樋口輝彦編)、日本医事新報、東京、2008.

  5. 堀弘明、功刀浩: 神経内分泌学. 「気分障害」(上島国利、樋口輝彦、野村総一郎、大野裕、神庭重信、尾崎紀夫編)、医学書院、東京、pp.245-252、2008.

  6. 功刀浩、堀弘明訳: 統合失調症100のQ&A−苦しみを乗り越えるために( リン・ E ・デリシ著: 100 Questions & Answers about Schizophrenia: Painful Minds). 星和書店、東京、2008.

 

2008 総説

  1. 功刀浩: 統合失調症の疾患概念と生物学的研究. 特集「統合失調症の生物学的研究」(特集編輯: 功刀浩)、メディカル・サイエンス・ダイジェスト 34: 568-569, 2008.

  2. 堀弘明、功刀浩: 統合失調症の神経生理学的研究. 特集「統合失調症の生物学的研究」(特集編輯: 功刀浩)、メディカル・サイエンス・ダイジェスト 34: 582-585, 2008.

  3. Adachi N, Kunugi H: Impaired secretion of brain-derived neurotrophic factor and neuropsychiatric diseases. The Open Neuroscience Journal (in press)

  4. Fujii T, Kunugi H: p75NTR as a therapeutic target for neuropsychiatric diseases. Current Molecular Pharmacology (in press)

  5. 藤井崇、功刀浩: 環境と神経新生―ストレス―. Clinical Neuroscience 26(8): 908-909, 2008.

  6. 功刀浩: 統合失調症の認知障害と分子生物学. Schizophrenia Frontier 8(4): 292-296, 2008.

 

2008 その他

  1. 泉愛子、功刀浩: 統合失調症の新規ターゲットであるmGlu2/3受容体の活性化: 無作為化臨床第2相試験(論文抄訳と解説). 分子精神医学 8(2): 142-144, 2008.

  2. 藤井崇、功刀浩: 薬物トランスポータ遺伝子ABCB1の多型は抗うつ薬の治療効果を予測する(論文抄訳と解説). 分子精神医学 8(4): 364-366, 2008.

  3. 岡崎祐士、谷井久志、佐々木司、加藤忠史、松本直通、染矢俊幸、有波忠雄、吉川武男、功刀浩: 精神疾患の遺伝子探索. 文部科学省科学研究補助金・特定領域研究「ゲノム」4領域2007年度報告書、pp.198-199、2008.

  4. 功刀浩、久保位可子、橋倉都、堀弘明、尾関祐二、高田孝二、大森まゆ、岡本長久、斉藤治、樋口輝彦、廣中直行: プレパルス抑制検査を用いた統合失調症の病態の解明と診断法の開発. 厚生労働精神・神経疾患研究委託費 「脳画像解析と生物学的指標を用いた精神疾患の診断と治療効果の判定への応用に関する研究」(主任研究者 三國雅彦) 総括研究報告書、pp.9-10、2008.