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2010

  1. Numakawa T, Yokomaku D, Richards M, Hori H, Adachi N, and Kunugi H. Functional interactions between steroid hormones and neurotrophin BDNF. World Journal of Biological Chemistry. (2010) in press.
  2. Chiba S, Numakawa T, Ninomiya M, Yoon HS, and Kunugi H. Cabergoline, a dopamine receptor agonist, has an antidepressant-like property and enhances brain-derived neurotrophic factor signaling. Psychopharmacology (Berl) (2010) in press.
  3. Ninomiya M, Numakawa T , Adachi N, Furuta M, Chiba S, Richards M, Shibata S, and Kunugi H. Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF. Neurosci Lett. (2010) 476, 104-109.
  4. Kitazawa H, Numakawa T, Adachi N, Kumamaru E, Tuerxun T, Kudo M, Kunugi H: Cyclophosphamide promotes cell survival via activation of intracellular signaling in cultured cortical neurons. Neurosci Lett 470(2): 139-144, 2010.
  5. Numakawa T, Suzuki S, Kumamaru E, Adachi N, Richards M, Kunugi H: BDNF function and intracellular signaling in neurons. Histol Histopathol 25(2): 237-258, 2010.
  6. Tuerxun T, Numakawa T, Adachi N, Kumamaru E, Kitazawa H, Kudo M, Kunugi H: SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett 469(3): 303-308, 2010.
  7. Kawashima H, Numakawa T, Kumamaru E, Adachi N, Mizuno H, Ninomiya M, Kunugi H, Hashido K: Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression. Neuroscience 165(4) :1301-1311, 2010.

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2009

  1. Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M, Someya T, Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S, Naka I, Ohashi J, Kakita A, Takahashi H, Nawa H, Arinami T: Brain Cannabinoid CB2 Receptor in Schizophrenia. Biol Psychiatry 2009 Nov 20. [Epub ahead of print]

  2. Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H: Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neurosci Lett 2009 Nov 13. [Epub ahead of print]

  3. Kajiyama Y, Iijima Y, Chiba S, Furuta M, Ninomiya M, Izumi A, Shibata S, Kunugi H: Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 2009 Oct 30. [Epub ahead of print]

  4. Okahisa Y, Ujike H, Kunugi H, Ishihara T, Kodama M, Takaki M, Kotaka T, Kuroda S: Leukemia inhibitory factor gene is associated with schizophrenia and working memory function. Prog Neuropsychopharmacol Biol Psychiatry 2009 Oct 30. [Epub ahead of print]

  5. Ohi K, Hashimoto R, Yasuda Y, Yamamori H, Hori H, Saitoh O, Tatsumi M, Takeda M, Iwata N, Ozaki N, Kamijima K, Kunugi H: No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. Neurosci Lett 463(1): 60-63, 2009. Epub 2009 Jul 24.

  6. Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T: Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2009 Jun 24. [Epub ahead of print]

  7. Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H: Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry Clin Neurosci 63(4): 550-556, 2009. Epub 2009 May 22.

  8. Kubota K, Inoue K, Hashimoto R, Kumamoto N, Kosuga A, Tatsumi M, Kamijima K, Kunugi H, Iwata N, Ozaki N, Takeda M, Tohyama M: Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression. J Neurochem 110(2): 496-508, 2009. Epub 2009 Apr 20.

  9. Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, Taya S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H: Association analysis between schizophrenia and the AP-3 complex genes. Neurosci Res 65(1): 113-115, 2009. Epub 2009 May 27.

  10. Watanabe Y, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T: A two-stage case-control association study of PADI2 with schizophrenia. J Hum Genet 54(7): 430-432, 2009. Epub 2009 May 29.

  11. Kawashima K, Ikeda M, Kishi T, Kitajima T, Yamanouchi Y, Kinoshita Y, Okochi T, Aleksic B, Tomita M, Okada T, Kunugi H, Inada T, Ozaki N, Iwata N: BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysis. Schizophr Res 112(1-3): 72-79, 2009. Epub 2009 Apr 29.

  12. Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Muchardt C, Yaniv M, Arinami T: Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. Hum Mol Genet 18(13): 2483-2494, 2009. Epub 2009 Apr 10.

  13. Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, Ozaki N, Kosuga A, Tatsumi M, Kamijima K, Harada S, Takeda M, Saitoh O, Kunugi H: A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry 2009 Apr 7. [Epub ahead of print]

  14. Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T: Preliminary genome-wide association study of bipolar disorder in the Japanese population. Am J Med Genet B Neuropsychiatr Genet 150B(8): 1110-1117, 2009.

  15. Numata S, Iga J, Nakataki M, Tayoshi S, Taniguchi K, Sumitani S, Tomotake M, Tanahashi T, Itakura M, Kamegaya Y, Tatsumi M, Sano A, Asada T, Kunugi H, Ueno S, Ohmori T: Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. Am J Med Genet B Neuropsychiatr Genet 150B(4): 527-534, 2009.

  16. Fukumoto N, Fujii T(double first author), Combarros O, Kamboh MI, Tsai SJ, Matsushita S, Nacmias B, Comings DE, Arboleda H, Ingelsson M, Hyman BT, Akatsu H, Grupe A, Nishimura AL, Zatz M, Mattila KM, Rinne J, Goto YI, Asada T, Nakamura S, Kunugi H: Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 2009 Jun 5. [Epub ahead of print]

  17. Kazuno AA, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T: Mitochondrial DNA haplogroup analysis in patients with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 150B(2): 243-247, 2009.

  18. Hashimoto R, Hirata Y, Asada T, Yamashita F, Nemoto K, Mori T, Moriguchi Y, Kunugi H, Arima K, Ohnishi T: Effect of the brain-derived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimer's disease. Genes Brain Behav 8(1): 43-52, 2009. Epub 2008 Sep 11.

  19. Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T: Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia. J Hum Genet 54(1): 62-65, 2009. Epub 2009 Jan 9.

  20. Hashimoto R, Mori T, Nemoto K, Moriguchi Y, Noguchi H, Nakabayashi T, Hori H, Harada S, Kunugi H, Saitoh O, Ohnishi T: Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging. World J Biol Psychiatry 10(1): 65-69, 2009.

  21. Numakawa T, Kumamaru E, Adachi N, Yagasaki Y, Izumi A, Kunugi H: Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC- signaling for glutamate release via a glutamate transporter. Proc Natl Acad Sci USA 106(2): 647-652, 2009. Epub 2009 Jan 6.

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2008

  1. Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T: TGFBR2 gene expression and genetic association with schizophrenia. J Psychiatr Res 42(6): 425-432, 2008. Epub 2007 Jun 8.

  2. Midorikawa A, Hashimoto R, Noguchi H, Saitoh O, Kunugi H, Nakamura K: Impairment of motor dexterity in schizophrenia assessed by a novel finger movement test. Psychiatry Res 159(3): 281-289, 2008. Epub 2008 Apr 29.

  3. Ohtsuki T, Koga M, Ishiguro H, Horiuchi Y, Arai M, Niizato K, Itokawa M, Inada T, Iwata N, Iritani S, Ozaki N, Kunugi H, Ujike H, Watanabe Y, Someya T, Arinami T: A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia. Schizophr Res 101(1-3): 9-16, 2008. Epub 2008 Mar 10.

  4. Richards M, Iijima Y, Shizuno T, Kamegaya Y, Hori H, Omori M, Arima K, Saitoh O, Kunugi H: Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population. J Neural Transm 115(9): 1347-1354, 2008. Epub 2008 Aug 12.

  5. Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, Tohyama M, Yamatodani A, Kunugi H, Hashimoto R: Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem Biophys Res Comm 373(2): 298-302, 2008. Epub 2008 Jun 13.

  6. Ishiguro H, Imai K, Koga M, Horiuchi Y, Inada T, Iwata N, Ozaki N, Ujike H, Itokawa M, Kunugi H, Sasaki T, Watanabe Y, Someya T, Arinami T: Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia. Psychiatr Genet 18(5): 255-256, 2008.

  7. Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yoshimura Y, Harada N, Miyake N, Nishimura A, Saitsu H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N: Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia. J Hum Genet 53(10): 914-919, 2008. Epub 2008 Aug 7.

  8. Hori H, Nagamine M, Soshi T, Okabe S, Kim Y, Kunugi H: Schizotypal traits in healthy women predict prefrontal activation patterns during a verbal fluency task: A near-infrared spectroscopy study. Neuropsychobiology 57(1-2): 61-69, 2008. Epub 2008 May 2.

  9. Noguchi H, Hori H, Kunugi H: Schizotypal traits and cognitive function in healthy adults. Psychiatry Res 161(2): 162-169, 2008. Epub 2008 Oct 11.

  10. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Saitoh O, Murray RM, Okabe S, Kunugi H: Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI). Psychiatry Res 160(2): 175-183, 2008. Epub 2008 Jul 7.

  11. Hori H, Ozeki Y, Terada S, Kunugi H: Functional near-infrared spectroscopy reveals altered hemispheric laterality in relation to schizotypy during verbal fluency task. Prog Neuropsychopharmacol Biol Psychiatry 32(8): 1944-51, 2008. Epub 2008 Oct 1.

  12. Izumi A, Iijima Y, Noguchi H, Numakawa T, Okada T, Hori H, Kato T, Tatsumi M, Kosuga A, Kamijima K, Asada T, Arima K, Saitoh O, Shiosaka S, Kunugi H: Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions. Neuropsychopharmacology 33(13): 3237-3245, 2008. Epub 2008 Mar 19.

  13. Kazuno AA, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T: Mitochondrial DNA haplogroup analysis in patients with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2008 Jun 10. [Epub ahead of print]

  14. Hashimoto R, Moriguchi Y, Yamashita F, Mori T, Nemoto K, Okada T, Hori H, Noguchi H, Kunugi H, Ohnishi T: Dose dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. Neurosci Res 61(4): 360-367. Epub 2008 Apr 20.

  15. Hori H, Noguchi H, Hashimoto R, Okabe S, Saitoh O, Kunugi H: IQ decline and memory impairment in Japanese patients with chronic schizophrenia. Psychiatry Res 158(2): 251-255, 2008. Epub 2008 Jan 28.

  16. Kumamaru E, Numakawa T, Adachi N, Yagasaki Y, Izumi A, Niyaz M, Kudo M, Kunugi H: Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol 22(3): 546-558, 2008. Epub 2007 Dec 20.

  17. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Takeda M, Kunugi H, Koyama T: A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 32(1): 204-208, 2008. Epub 2007 Aug 19.

  18. Nunokawa A, Watanabe Y, Kitamura H, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Ozaki N, Someya T: Large-scale case-control study (and meta-analysis) of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia. Psychiatry Clin Neurosci 62(2): 239-240, 2008.

  19. Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T: TGFBR2 gene expression and genetic association with schizophrenia. J Psychiatr Res 42(6): 425-432, 2008. Epub 2007 Jun 8.

  20. Ozeki Y, Mizuguchi T, Hirabayashi N, Ogawa M, Ohmura N, Moriuchi M, Harada N, Matsumoto N, Kunugi H: A case of schizophrenia with chromosomal microdeletion of 17p11.2 containing a myelin-related gene PMP22. The Open Psychiatry Journal 2: 1-4, 2008.

  21. Kumamaru E, Numakawa T, Adachi N, Yagasaki Y, Izumi A, Niyaz M, Kudo M, Kunugi H: Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol 22(3): 546-558, 2008. Epub 2007 Dec 20.

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2007

  1. Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H: A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects. Neurosci Lett 428(1): 17-20, 2007. Epub 2007 Sep 26.

  2. Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A: Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Mol Psychiatry 12(11): 1026-1032, 2007. Epub 2007 Mar 27.

  3. Tamura Y, Kunugi H, Ohashi J, Hohjoh H: Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry 12(6): 519, 593-600, 2007. Epub 2007 Feb 20.

  4. Niyaz M, Numakawa T, Matsuki Y, Kumamaru E, Adachi N, Kitazawa H, Kunugi H, Kudo M: MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling. J Neurosci Res 85(13): 2933-2942, 2007. Epub 2007 Jul 12.

  5. Kunugi H, Tanaka M, Hori H, Hashimoto R, Saitoh O, Hironaka N: Prepulse inhibition of acoustic startle in Japanese patients with chronic schizophrenia. Neurosci Res 59(1): 23-28, 2007. Epub 2007 May 25.

  6. Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Umekage T, Tochigi M, Kohda K, Sasaki T, Yamada K, Yoshikawa T, Kato T: Association analysis of HSP90B1 with bipolar disorder. J Hum Genet 52(10): 794-803, 2007. Epub 2007 Sep 4.

  7. Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M, Ozaki N, Iwata N, Sakamoto K, Iijima Y, Iwata Y, Tsuchiya KJ, Sugihara G, Nanko S, Osumi N, Detera-Wadleigh SD, Kato T, Yoshikawa T: A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. Neuropsychopharmacology 32(8): 1727-1737, 2007. Epub 2007 Jan 24.

  8. Hattori S, Hashimoto R, Miyakawa T, Yamanaka H, Maeno H, Wada K, Kunugi H: Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi. Behav Brain Res 180(1): 69-76, 2007. Epub 2007 Feb 28.

  9. Fujii T, Iijima Y, Kondo H, Shizuno T, Hori H, Nakabayashi T, Arima K, Saitoh O, Kunugi H: Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry 31(4): 873-877, 2007. Epub 2007 Feb 7.

  10. Munakata K, Fujii K, Nanko S, Kunugi H, Kato T: Sequence and functional analyses of mtDNA in a maternally inherited family with bipolar disorder and depression. Mutat Res 617(1-2): 119-124, 2007. Epub 2007 Jan 21.

  11. Numata S, Ueno SI, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T: Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia. Neurosci Lett 415(1): 28-33, 2007. Epub 2007 Jan 11.

  12. Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Yamada K, Yoshikawa T, Kato T: Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder. Neurosci Lett 417(3): 316-321, 2007. Epub 2007 Feb 24.

  13. Mori T, Ohnishi T, Hashimoto R, Nemoto K, Moriguchi Y, Noguchi H, Nakabayashi T, Hori H, Harada S, Saitoh O, Matsuda H, Kunugi H: Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging. Psychiatry Res: Neuroimaging 154(2): 133-145, 2007. Epub 2007 Feb 5.

  14. Numakawa Y, Matsumoto T, Yokomaku D, Taguchi T, Niki E, Hatanaka H, Kunugi H, Numakawa T: 17beta-estradiol protects cortical neurons against oxidative stress-induced cell death through reduction in the activity of mitogen-activated protein kinase and in the accumulation of intracellular calcium. Endocrinology 148(2): 627-637, 2007. Epub 2006 Nov 2.

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2006

  1. Ohnishi T, Hashimoto R, Mori T, Nemoto K, Moriguchi Y, Iida H, Noguchi H, Nakabayashi T, Hori H, Ohmori M, Tsukue R, Anami K, Hirabayashi N, Harada S, Arima K, Saitoh O, Kunugi H: The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia. Brain 129(Pt 2): 399-410, 2006. Epub 2005 Dec 5.

  2. Matsumoto T, Numakawa T, Yokomaku D, Adachi N, Yamagishi S, Numakawa Y, Kunugi H, Taguchi T: Brain-derived neurotrophic factor-induced potentiation of glutamate and GABA release: different dependency on signaling pathways and neuronal activity. Mol Cell Neurosci 31(1): 70-84, 2006. Epub 2005 Oct 7.

  3. Kunugi H, Ida I, Owashi T, Kimura M, Inoue Y, Nakagawa S, Yabana T, Urushibara T, Kanai R, Aihara M, Yuuki N, Otsubo T, Oshima A, Kudo K, Inoue T, Kitaichi Y, Shirakawa O, Isogawa K, Nagayama H, Kamijima K, Nanko S, Kanba S, Higuchi T, Mikuni M: Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a Multicenter Study. Neuropsychopharmacology 31(1): 212-220, 2006.

  4. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Kunugi H, Koyama T: A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder. Int J Neuropsychopharmacol 9(1) : 83-88, 2006. Epub 2005 Jun 1.

  5. Richards M, Iijima Y, Kondo H, Shizuno T, Hori H, Arima K, Saitoh O, Kunugi H: Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population. Behav Brain Funct 2: 39, 2006.

  6. Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H: Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet 15(20): 3024-3033, 2006. Epub 2006 Sep 7.

  7. Nakanishi S, Kunugi H, Murray RM, Nojima S, Ogawa T, Takahashi T: Effects of switching from conventional antipsychotics to risperidone in Japanese patients with chronic schizophrenia. Psychiatry Clin Neurosci 60(6):751-757, 2006.

  8. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Omori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Harada S, Saitoh O, Iwase M, Kajimoto O, Takeda M, Okabe S, Kunugi H: Antipsychotic medication and cognitive function in schizophrenia. Schizophr Res 86(1-3): 138-146, 2006. Epub 2006 Jun 21.

  9. Kunugi H, Hashimoto R, Okada T, Hori H, Nakabayashi T, Baba A, Kudo K, Omori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Kosuga A, Tatsumi M, Kamijima K, Asada T, Harada S, Arima K, Saitoh O: Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population. J Neural Transm 113(10): 1569-1573, 2006. Epub 2006 Apr 11.

  10. Yagasaki Y, Numakawa T, Kumamaru E, Hayashi T, Su TP, Kunugi H: Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release. J Biol Chem 281(18): 12941-12949, 2006. Epub 2006 Mar 6.

  11. Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M, Kamijima K, Kato T, Kunugi H: A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity. Mol Psychiatry 11(7): 695-703, 2006. Epub 2006 Mar 28.

  12. Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T: Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder. Psychiatr Genet 16(2): 49-50, 2006.

  13. Chiba S, Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger DR, Kunugi H: Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus. J Neural Transm 113(9): 1337-1346, 2006. Epub 2006 Feb 6.

  14. Hashimoto R, Hattori S, Chiba S, Yagasaki Y, Okada T, Kumamaru E, Mori T, Nemoto K, Tanii H, Hori H, Noguchi H, Numakawa T, Ohnishi T, Kunugi H: Susceptibility genes for schizophrenia. Psychiatry Clin Neurosci 60(Suppl 1): S4-S10, 2006.

  15. Tanaka K, Shintani N, Hashimoto H, Kawagishi N, Ago Y, Matsuda T, Hashimoto R, Kunugi H, Yamamoto A, Kawaguchi C, Shimada T, Baba A: Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice. J Neurosci 26(19): 5091-5097, 2006.

  16. Numakawa Y, Numakawa T, Matsumoto T, Yagasaki Y, Kumamaru E, Kunugi H, Taguchi T, Niki E: Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J Neurochem 97(4): 1191-1202, 2006.

  17. Nemoto K, Ohnishi T, Mori T, Moriguchi Y, Hashimoto R, Asada T, Kunugi H: The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology. Neurosci Lett 397(1-2): 25-29, 2006. Epub 2006 Jan 18.

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2005

  1. Hashimoto R, Okada T, Kato T, Kosuga A, Tatsumi M, Kamijima K, Kunugi H: The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder. Biol Psychiatry 57(10): 1097-1102, 2005.

  2. Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H: Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. J Neural Transm 112(2): 303-307, 2005.

  3. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H: A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men. Schizophr Res 73(2-3): 383-385, 2005.

  4. Yamagishi S, Matsumoto T, Numakawa T, Yokomaku D, Adachi N, Hatanaka H, Yamada M, Shimoke K, Ikeuchi T: ERK1/2 are involved in low potassium-induced apoptotic signaling downstream of ASK1-p38 MAPK pathway in cultured cerebellar granule neurons. Brain Res 1038(2): 223-230, 2005.

  5. Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Ohara K, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa SI, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y; Japanese Schizophrenia Sib-Pair Linkage Group. Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet 77(6): 937-944, 2005. Epub 2005 Oct 12.

  6. Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Umekage T, Tochigi M, Kohda K, Sasaki T, Yamada K, Yoshikawa T, Kato T: Functional polymorphisms of HSPA5: possible association with bipolar disorder. Biochem Biophys Res Com 336(4): 1136-1143, 2005.

  7. Kusumi I, Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama T: Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI. Neurosci Lett 391(1-2): 7-10, 2005. Epub 2005 Sep 9.

  8. Tadokoro K, Hashimoto R, Tatsumi M, Kosuga A, Kamijima K, Kunugi H: The Gem interacting protein (GMIP) gene is associated with major depressive disorder. Neurogenetics 6(3): 127-133, 2005. Epub 2005 Sep 28.

  9. Kazuno AA, Munakata K, Mori K, Tanaka M, Nanko S, Kunugi H, Umekage T, Tochigi M, Kohda K, Sasaki T, Akiyama T, Washizuka S, Kato N, Kato T: Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'. Psychiatry Clin Neurosci 59(4): 497-503, 2005.

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2004

  1. Kunugi H, Urushibara T, Nanko S: Combined DEX/CRH test among Japanese patients with major depression. J Psychiatr Res 38(2): 123-128, 2004.

  2. Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H: Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-) gene in Japanese patients with schizophrenia. J Neural Transm 111(2): 217-221, 2004.

  3. Nakanishi S, Kunugi H, Takahashi T: Efficacy of milnacipran for depressive symptoms in schizophrenia spectrum disorders. Psychiatry Clin Neurosci 58(2): 226-227, 2004.

  4. Hashimoto R, Straub RE, Weickert CS, Hyde TM, Kleinman JE, Weinberger DR: Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia. Mol Psychiatry 9(3): 299-307, 2004.

  5. Omi K, Tokunaga K, Hohjoh H: Long-lasting RNAi activity in mammalian neurons. FEBS Lett 558(1-3): 89-95, 2004.

  6. Hohjoh H: Enhancement of RNAi activity by improved siRNA duplexes. FEBS Lett 557(1-3): 193-198, 2004.

  7. Munakata K, Tanaka M, Mori K, Washizuka S, Yoneda M, Tajima O, Akiyama T, Nanko S, Kunugi H, Tadokoro K, Ozaki N, Inada T, Sakamoto K, Fukunaga T, Iijima Y, Iwata N, Tatsumi M, Yamada K, Yoshikawa T, Kato T: Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder. Genomics 84(6): 1041-1050, 2004.

  8. Numakawa T, Yagasaki Y, Ishimoto T, Suzuki T, Iwata N, Ozaki N , Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, Hashimoto R: Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet 13(21): 2699-2708, 2004. Epub 2004 Sep 2.

  9. Numakawa T, Ishimoto T, Suzuki S, Numakawa Y, Adachi N, Matsumoto T, Yokomaku D, Koshimizu H, Fujimori KE, Hashimoto R, Taguchi T, Kunugi H: Neuronal roles of the integrin-associated protein (IAP/CD47) in developing cortical neurons. J Biol Chem 279(41): 43245-43253, 2004. Epub 2004 Aug 5.

  10. Washizuka S, Iwamoto K, Kazuno A, Kakiuchi C, Mori K, Kametani M, Yamada K, Kunugi H , Tajima O, Akiyama T, Nanko S, Yoshikawa T, Kato T: Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees. Biol Psychiatry 56(7): 483-489, 2004.

  11. Kusumi I, Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama T: Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects. Neurosci Lett 369(1): 1-3, 2004.

  12. Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Fukunaga T, Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T: No association between the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in Japanese: a multicenter study. Biol Psychiatry 56(5): 376-378, 2004.

  13. Tadokoro K, Hashimoto R, Tatsumi M, Kamijima K, Kunugi H: Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. Neuropsychobiology 50(3): 206-210, 2004.

  14. Kakiuchi C, Nanko S, Kunugi H, Kato T: Reply to "Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin". Nat Genet 36(8): 784-785, 2004.

  15. Kunugi H, Hashimoto R, Yoshida M, Tatsumi M, Kamijima K: A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. Am J Med Genet 129B(1): 44-46, 2004.

  16. Sago N, Omi K, Tamura Y, Kunugi H, Toyo-oka T, Tokunaga K, Hohjoh H: RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed. Biochem Biophys Res Commun 319(1): 50-57, 2004.

  17. Hashimoto R, Straub RE, Weickert CS, Hyde TM, Kleinman JE, Weinberger DR: Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia. Mol Psychiatry 9(3): 299-307, 2004.

  18. Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R , Hyde TM, Herman MM, Weinberger DR, Kleinman JE: Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry 61(6): 544-555, 2004.

  19. Suzuki S, Numakawa T, Shimazu K, Koshimizu H, Hatanaka H, Mei L, Lu B, Kojima M: BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol 167(6): 1205-1215, 2004. Epub 2004 Dec 13.

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2003

  1. Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T: Impaired feedback regulation of XBP1 as a genetic risk factor of bipolar disorder. Nat Genet 35(2): 171-175, 2003. Epub 2003 Aug 31.

  2. Nanko S, Kunugi H, Hirasawa H, Kato N, Nabika T, Kobayashi S: Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. Schizophr Res 62(3): 281-283, 2003.

  3. Washizuka S, Kakiuchi C, Mori K, Kunugi H, Tajima O, Akiyama T, Nanko S, Kato T: Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 120B(1): 72-78, 2003.

  4. Kunugi H, Urushibara T, Murray RM, Nanko S, Hirose T: Prenatal underdevelopment and schizophrenia: a case report of monozygotic twins. Psychiatry Clin Neurosci 57(3): 271-274, 2003.

  5. Kato T, Iwamoto K, Washizuka S, Mori K, Tajima O, Akiyama T, Nanko S, Kunugi H, Kato N: No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans. Neurosci Lett 338(1): 21-24, 2003.

  6. Hashimoto R, Senatorov V, Kanai H, Leeds P, Chuang DM: Lithium stimulates progenitor proliferation in cultured brain neurons. Neuroscience 117(1): 55-61, 2003.

  7. Hashimoto R, Fujimaki K, Jeong MR, Christ L, Chuang DM: Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity. FEBS Lett 538(1-3): 145-148, 2003.

  8. Jeong MR, Hashimoto R, Senatorov VV, Fujimaki K, Ren M, Lee MS, Chuang DM: Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition. FEBS Lett 542(1-3): 74-78, 2003.

  9. Matsumoto N, Nakamura Y, Kashiwagi Y, Hashimoto R, Kudo T, Tanaka T, Shinosaki K, Takeda M: Involvement of Rho-associated kinase in neurite sprouting and amyloid beta production of rat cortical neurons cultured in insulin-free medium. Psychogeriatrics 3(1): 21-28, 2003.

  10. Hohjoh H, Ohashi J, Takasu M, Nishioka T, Ishida T, Tokunaga K: Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species. Immunogenetics 54(12): 856-861, 2003. Epub 2003 Mar 7.

  11. Hohjoh H, Takasu M, Shishikura K, Takahashi Y, Honda Y, Tokunaga K: Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics 4(3): 151-153, 2003. Epub 2002 Nov 29.

  12. Numakawa T, Nakayama H, Suzuki S, Kubo T, Nara F, Numakawa Y, Yokomaku D, Araki T, Ishimoto T, Ogura A, Taguchi T: Nerve growth factor-induced glutamate release is via p75 receptor, ceramide, and Ca(2+) from ryanodine receptor in developing cerebellar neurons. J Biol Chem 278(42): 41259-41269, 2003. Epub 2003 Aug 5.

  13. Nakahata Y, Okumura N, Otani H, Hamada J, Numakawa T, Sano S, Nagai K: Stimulation of BIT induces a circadian phase shift of locomotor activity in rats. Brain Res 976(2): 194-201, 2003.

  14. Yokomaku D, Numakawa T, Numakawa Y, Suzuki S, Matsumoto T, Adachi N, Nishio C, Taguchi T, Hatanaka H: Estrogen enhances depolarization-induced glutamate release through activation of phosphatidylinositol 3-kinase and mitogen-activated protein kinase in cultured hippocampal neurons. Mol Endocrinol 17(5): 831-844, 2003. Epub 2003 Jan 23.

  15. Otomo A, Hadano S, Okada T, Mizumura H, Kunita R, Nishijima H, Showguchi-Miyata J, Yanagisawa Y, Kohiki E, Suga E, Yasuda M, Osuga H, Nishimoto T, Narumiya S, Ikeda JE: ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics. Hum Mol Genet 12(14): 1671-1687, 2003.

  16. Hattori S, Murakami F, Song WJ: Rundown of a transient potassium current is attributable to changes in channel voltage dependence. Synapse 48(2): 57-65, 2003.

  17. Hattori S, Murakami F, Song WJ: Quantitative relationship between Kv4.2 mRNA and A-type K+ current in rat striatal cholinergic interneurons during development. J Neurophysiol 90(1): 175-183, 2003.

  18. Saitoh K, Hattori S, Song WJ, Isa T, Takakusaki K: Nigral GABAergic inhibition upon cholinergic neurons in the rat pedunculopontine tegmental nucleus. Eur J Neurosci 18(4): 879-886, 2003.

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