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The following list is the most highly-cited papers published by our laboratory and our collaborators. ( More than 40.0 )
The data source is based on Google Scholar.
- Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., Okuyama, S., Kawashima, N., Hori, S., Takimoto, M. and Wada, K.,
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science, 276, 1699-1702, 1997
cited by 702
- Wada E, Wada K, Boulter J, Deneris E, Heinemann S, Patrick J, Swanson LW. Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat. J Comp Neurol. 8, 284, 314-35, 1989
cited by 611
- RJ Wenthold, N Yokotani, K Doi and K Wada Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain J. Biol. Chem., 267, 501-507, 1992
cited by 373
- Saigoh, K., Wang, Y.-L., Suh, J.G., Yamanishi, T., Sakai, Y., Kiyosawa, H., Harada, T., Ichihara, N., Wakana, S., Kikuchi, T. and Wada, K., Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mouse. Nature Genet., 23, 47-51,1999
cited by 291
- K Wada, M Ballivet, J Boulter, J Connolly, E Wada, ES Deneris, LW Swanson, S Heinemann, and J Patrick Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor?Science 240, 330-334, 1988
cited by 209
- Evan S. Deneris, John Connolly, Jim Boulter, Etsuko Wada, Keiji Wada, Larry W. Swanson, Jim Patrick, and Steve Heinemann?Primary structure and expression of beta2: A novel subunit of neuronal nicotinic acetylcholine receptors Neuron, 1, 45-54, 1988
cited by 202
- Shibata, T., Yamada, K., Watanabe, M., Ikenaka, K., Wada, K., Tanaka, K. and Inoue, Y.,Glutamate transporter GLAST Is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J. Neurosci., 17, 9212-9219, 1997
cited by 181
- Watase, K., Hashimoto, K., Kano, M., Yamada, K., Watanabe, M., Inoue, Y., Okuyama, S., Sakagawa, T., Ogawa, S., Kawashima, N., Hori, S., Takimoto, M., Wada, K. and Tanaka, K. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur. J Neurosci., 10, 976-988, 1998
cited by 180
- Ohki-Hamazaki, H., Watase, K., Yamamoto, K., Ogura, H., Yamano, M., Yamada, K., Maeno, H., Imaki, J., Kikuyama, S., Wada, E. and Wada, K., Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Nature, 390, 165-169, 1997
cited by 158
- Charles W. Luetje, Keiji Wada, Scott Rogers, Stewart N. Abramson, Kuniro Tsuji, Steve Heinemann, and Jim Patrick Neurotoxins Distinguish Between Different Neuronal Nicotinic Acetylcholine Receptor Subunit Combinations Journal of Neurochemistry, 55, 632-640, 1990
cited by 155
- Matsui, T., Sekiguchi, M., Hashimoto, A., Tomita, U., Nishikawa, T. and Wada, K., Functional comparison of D-serine and glycine: the effect on cloned NMDA receptors and the extracellular concentration. J. Neurochem. 65, 454-458, 1995
cited by 147
- Tomita, S., Adesnik, H., Sekiguchi, M., Zhang, W., Wada, K., Howe, J.R., Nicoll, R.A., Bredt, D.S. Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature, 435, 1052-1058, 2005
cited by 143
- Osaka, H., Wang, Y.L., Takada, K., Takizawa, S., Setsuie, R., Li, H., Sato, Y., Nishikawa, K., Sun, Y.J., Sakurai, M., Harada, T., Hara, Y., Kimura, I., Chiba, S., Namikawa, K., Kiyama, H., Noda, M., Aoki, S. and Wada, K. Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neurons. Hum. Mol. Genet., 12, 1945-1958, 2003
cited by 140
- Harada, T., Harada, C., Watanabe, M., Inoue, Y., Sakagawa, T., Nakayama, N., Sasaki, S., Okuyama, S., Watase, K., Wada, K., and Tanaka, K., Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc. Natl. Acad. Sci., USA 95, 4663-4666, 1998
cited by 139
- Wada, K., Dechesne, C.J., Shimasaki, S., King, R.G., Kusano, K., Buonanno, A., Hampson, D.R., Banner, C., Wenthold, R.J. and Nakatani, Y. Sequence and expression of a frog brain complementary DNA encoding a kainate-binding protein. Nature 342, 684-689, 1989
cited by 129
- Harada, T., Harada, C., Kohsaka, S., Wada, E., Yoshida, S., Ohno, S., Mamada, H., Tanaka, K., Parada, L.F., and Wada, K. Microglia-Muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J. Neurosci., 22, 9228-9236, 2002
cited by 126
- Harada, T., Harada, C., Nakayama, N., Okuyama, S., Yoshida, K., Kohsaka, S., Matsuda, H. and Wada, K., Modification of glial-neuronal interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron, 26, 533-541, 2000
cited by 114
- Yamada, K., Watanabe M., Shibata, T., Tanaka, K., Wada, K. and Inoue, Y., EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses. Neuroreport , 7, 2013-2017, 1996
cited by 102
- Sekiguchi, M., Fleck, M.W., Mayer, M.L., Takeo, J., Chiba, Y., Yamashita, S. and Wada, K. A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino) ehtylthio]-2,6-difluoro-phenoxyacetamide. J. Neurosci., 17, 5760-5771, 1997
cited by 72
- Nishikawa, K., Li, H., Kawamura, R., Osaka, H., Wang, Y.L., Hara, Y., Hirokawa, T., Manago, Y., Amano, T, Noda, M., Aoki, S. and Wada, K. Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants. Biochem. Biophys. Res. Comm., 304, 176-183, 2003.
cited by 71
- Wang YL, Liu W, Wada E, Murata M, Wada K, Kanazawa I. Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA. Neurosci. Res. 53, 241-249, 2005
cited by 62
- Kiryu-Seo, S., Sasaki, M., Yokohama, H., Nakagomi, S., Hirayama, T., Aoki, S., Wada, K. and Kiyama, H., Damage induced neuronal endopeptidase (DINE) is a novel metallopeptidase expressed in response to neuronal damage and promotes superoxide scavengers expressions. Proc. Natl. Acad. Sci. USA, 97, 4345-4350, 2000
cited by 61
- Shibata, T., Watanabe, M., Tanaka, K., Wada, K. and Inoue, Y. Dynamic changes in expression of glutamate transporter mRNAs in developing brain. Neuroreport, 7, 705-709, 1996
cited by 60
- Castegna, A., Thongboonkerd, V., Klein, J., Lynn, B., Wang, Y.L., Osaka, H., Wada, K. and Butterfield, D.A. Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins. J. Neurochem., 88, 1540-1546, 2004
cited by 58
- Kojima, S., Nakamura, T., Nidaira, T., Nakamura, K., Ooashi, N., Ito, E., Watase, K., Tanaka, K., Wada, K., Kudo, Y. and Miyakawa, H. Optical detection of synaptically induced glutamate transport in hippocampal slices. J. Neurosci., 19, 2580-2588, 1999
cited by 56
- Aida, R., Moriya, T., Araki, M., Akiyama, M., Wada, K., Wada, E. and Shibata, S. Gastrin-releasing peptide (GRP) mediates photic entrainable signals to the dorsal subsets of suprachiasmatic nucleus via induction of period gene in mice. Mol. harmacol., 61, 26-34, 2002
cited by 55
- Harada T, Harada C, Wang YL, Osaka H, Amanai K, Tanaka K, Takizawa S, Setsuie R, Sakurai M, Sato Y, Noda M, Wada K. Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. Am. J. Pathol. 164, 59-64, 2004
cited by 52
- Kurihara, L.J., Kikuchi, T., Wada, K. and Tilghman, S.M., Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum. Mol. Genet., 10, 1963-1970, 2001
cited by 52
- Ohki-Hamazaki, H., Sakai, Y., Kamata, K., Ogura, H., Okuyama, S., Watase, K., Yamada, K. and Wada, K. Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor. J. Neurosci., 19, 948-954, 1999
cited by 51
- Wada, K., Yokotani, N., Hunter, C., Doi, K., Wenthold, R.J. and Shimasaki,S., Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. Proc. Natl. Acad. Sci. USA, 89, 197-201, 1992.
cited by 50
- Mi W, Beirowski B, Gillingwater TH, Adalbert R, Wagner D, Grumme D, Osaka H, Conforti L, Arnhold S, Addicks K, Wada K, Ribchester RR, Coleman MP. The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice. Brain. 128, 405-416, 2005
cited by 49
- Wada, E., Watase, K., Yamada, K. Ogura, H., Yamano, M., Inomata, Y., Eguchi, J., Yamamoto, K., Maeno, H., Mikoshiba, K., Ohki-Hamazaki, H., and Wada, K., Generation and characterization of mice lacking gastrin releasing peptide receptor. Biochem. Biophys. Res. Comm., 239, 28-33, 1997
cited by 47
- Kabuta T, Suzuki Y, Wada K. Degradation of amyotrophic lateral sclerosis-linked mutant Cu,Zn-superoxide dismutase proteins by macroautophagy and the proteasome. J. Biol. Chem. 281, 30524-30533, 2006
cited by 42
- Sekiguchi M, Wada K, Wenthold RJ. N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes. FEBS Lett. 311, 285-289, 1992
cited by 42
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