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Section Chief : Tomohiro Kabuta

< Biography >

EDUCATION:
2004 PhD, University of Tokyo

PROFESSIONAL TRAINING:
April, 2004 Postdoctoral fellow, Department of Animal Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan

2004-2010 Postdoctoral fellow, Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo Japan

March, 2010 - present
Section Chief, Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo Japan

< Selected publications >

  1. Aizawa S, Contu VR, Fujiwara Y, Hase K, Kikuchi H, Kabuta C, Wada K, *Kabuta T.
    Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes.
    Autophagy. 2017 Jan 2;13(1):218-222.

  2. Aizawa S, Fujiwara Y, Contu VR, Hase K, Takahashi M, Kikuchi H, Kabuta C, Wada K, *Kabuta T.
    Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes.
    Autophagy. 2016 Mar;12(3):565-578.

  3. Hase K, Fujiwara Y, Kikuchi H, Aizawa S, Hakuno F, Takahashi S, Wada K, *Kabuta T.
    RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates.
    Nucleic Acids Res. 2015 Jul;43(13):6439-6449.

  4. Fujiwara Y, Kikuchi H, Aizawa S, Furuta A, Hatanaka Y, Konya C, Uchida K, Wada K, *Kabuta T.
    Direct uptake and degradation of DNA by lysosomes. Autophagy. 2013 Aug;9(8):1167-71.
  5. *Kabuta T, Mitsui T, Fujiwara Y, Furuta A, Kikuchi H, Aizawa S, Hatanaka Y, Konya C, Uchida K, Yoshimura A, Tamai Y, Wada K.
    Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation Independently of Its Hydrolase Activity. J Biol Chem. 2013 May 3;288(18):12615-26.
  6. Fujiwara Y, Furuta A, Kikuchi H, Aizawa S, Hatanaka Y, Konya C, Uchida K, Yoshimura A, Tamai Y, Wada K, *Kabuta T.
    Discovery of a novel type of autophagy targeting RNA. Autophagy. 2013 Mar;9(3):403-9.
  7. Konya C, Hatanaka Y, Fujiwara Y, Uchida K, Nagai Y, Wada K, *Kabuta T.
    Parkinson's disease-associated mutations in alpha-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L1. Neurochem. Int. 2011 Aug;59(2):251-8.
  8. Higashi S, Tsuchiya Y, Araki T, Wada K, *Kabuta T.
    TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase. Neurochem. Int. 2010 Dec;57(8):906-13.
  9. Higashi S, Iseki E, Minegishi M, Togo T, *Kabuta T, Wada K.
    GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. J. Neurochem. 2010 Oct;115(2):423-37.
  10. Mitsui T, Hirayama K, Aoki S, Nishikawa K, Uchida K, Matsumoto T, *Kabuta T, Wada K.
    Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening. Neurochem. Int. 2010 Apr;56(5):679-86.
  11. *Kabuta T, Kinugawa A, Tsuchiya Y, Kabuta C, Setsuie R, Tateno M, Araki T, Wada K.
    Familial amyotrophic lateral sclerosis-linked mutant SOD1 aberrantly interacts with tubulin. Biochem. Biophys. Res. Commun. 2009 Sep 11;387(1):121-6.
  12. *Kabuta T, Wada K.
    Insights into links between familial and sporadic Parkinson's disease: physical relationship between UCH-L1 variants and chaperone-mediated autophagy. Autophagy. 2008 Aug;4(6):827-9.
  13. *Kabuta T, Furuta A, Aoki S, Furuta K, Wada K.
    Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J. Biol. Chem. 2008 Aug 29;283(35):23731-8.
  14. *Kabuta T, Setsuie R, Mitsui T, Kinugawa A, Sakurai M, Aoki S, Uchida K, Wada K.
    Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1. Hum. Mol. Genet. 2008 May 15;17(10):1482-96.
  15. Kabuta T, Suzuki Y, Wada, K.
    Degradation of amyotrophic lateral sclerosis-linked mutant Cu,Zn-superoxide dismutase proteins by macroautophagy and the proteasome. J. Biol. Chem. 2006 Oct 13;281(41):30524-33.
  16. Kabuta T, Hakuno F, Asano T, Takahashi S.
    Insulin receptor substrate-3 functions as transcriptional activator in the nucleus. J. Biol. Chem. 2002 Mar 1;277(9):6846-51.

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