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Section Chief : Yoshitaka Nagai

< Biography >

1990 MD, Osaka University Medical School
1990-1991 Resident, Second Department of Internal Medicine and Neurology, Osaka University Hospital
1995 PhD, Osaka University Graduate School of Medicine
1995-1997 Medical Staff, Second Department of Internal Medicine, Osaka Medical Center For Cancer and Cardiovascular Diseases
1997-2000 Research Associate, Division of Neurology, Department of Medicine, Duke University Medical Center

2000-2001 Postdoctoral fellow, Department of Molecular Medical Science, Osaka Bioscience Institute
2001-2007 Assistant Professor, Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine
2007-2008 Associate Professor, Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine
October, 2008 - present
Section Chief, Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo Japan

< Selected publications >

  1. Nagai, Y., Tucker, T., Ren, H., Kenan, D.J., Henderson, B.S., Keene, J.D., Strittmatter, W.J., Burke, J.R.
    Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. J. Biol. Chem., 275, 10437-10442, 2000
  2. *Nagai, Y., Fujikake, N., Ohno, K., Higashiyama, H., Popiel, H.A., Rahadian, J., Yamaguchi, M., Strittmatter, W.J., Burke, J.R., Toda, T.
    Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila. Hum. Mol. Genet., 12, 1253-1260, 2003
  3. Popiel, H.A., *Nagai, Y., Fujikake, N., Toda, T.
    Protein transduction domain-mediated delivery of QBP1 suppresses polyglutamine-induced neurodegeneration in vivo. Mol. Ther., 15, 303-309, 2007
  4. *Nagai, Y., Inui, T., Popiel, H.A., Fujikake, N., Hasegawa, K., Urade, Y., Goto, Y., Naiki, H., Toda, T.
    A toxic monomeric conformer of the polyglutamine protein. Nat. Struct. Mol. Biol., 14, 332-340, 2007
  5. Takahashi, Y., Okamoto, Y., Popiel, H.A., Fujikake, N., Toda, T., Kinjo, M., *Nagai, Y.
    Detection of polyglutamine protein oligomers in cells by fluorescence correlation spectroscopy. J. Biol. Chem., 282, 24039-24048, 2007
  6. Fujikake, N., *Nagai, Y., Popiel, H.A., Okamoto, Y., Yamaguchi, M., Toda, T.
    Heat shock transcription factor 1 (HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones. J. Biol. Chem. (in press)
  7. *Nagai, Y., Popiel, H.A.
    Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases: Exposed -sheet hypothesis Curr. Pharm. Des. (in press)

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