List of Publications

• 2023
• 2022
• 2021
• 2020
• 2019
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2011
• 2010
• 2009
• -2007

2023

• Numata-Uematasu Y, Wakatsuki S, Kobayashi-Ujiie Y Sakai K, Ichinohe N, Araki T.
  In vitro myelination using explant culture of dorsal root ganglia: an efficient tool for analyzing peripheral nerve differentiation and disease modeling.
  PLOS One 10.1371/journal.pone.0285897, 2023.

• Zhang S, Ohkawara B, Ito M, Huang Z, Zhao F, Nakata T, Takeuchi T, Sakurai H, Komaki H, Kamon M, Araki T, Ohno K.
  A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells.
  Hum Mol Genet 32: 1511–1523, 2023.

• Wakatsuki S, Araki T.
  Novel insights into the mechanism of ROS-mediated neurodegeneration: selective phosphorylation of p47-phox serves as a priming signal of ROS-mediated neurite degeneration.
  Neural Regeneration Research　 18(4):746-749, 2023.

2022

• Das J, Forlini C, Porcello DM, Rommelfanger KS, Salles A, Global Neuroethics Summit Delegates.
  Neuroscience is ready for neuroethics engagement
  Frontiers in Communication. 7: 909964, 2022.

• Nakazawa E, Fukushi T, Tachibana K, Uehara R, Arie F, Akter N, Maruyama M, Morita K, Araki　T, Sadato N.
  The way forward for neuroethics in Japan: A review of five topics surrounding present challenges.
  Neuroscience Research,183:7-16, 2022.

• Hashimoto Y, Kuniishi H, Sakai K, Fukushima Y, Du X , Yamashiro K, Hori K, Imamura M, Hoshino M, Yamada M, Araki T, Itaka K, Sakagami H, Takeda S, Itaka K, Ichinohe N, Muntoni F, Sekiguchi M, Aoki Y.
  Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy.
  Progress in Neurobiology 216: 102288, 2022.

• Nakamori M, Shimizu H, Ogawa K, Hasuike Y, Nakajima T, Sakurai H, Araki T, Okada Y, Kakita A, Mochizuki H.
  Cell type-specific abnormalities of central nervous system in myotonic dystrophy type 1.
  Brain Communications 4(3):fcac154, 2022.

• Wakatsuki S, Takahashi Y, Shibata M, Araki T.
  Selective phosphorylation of serine 345 on p47-phox serves as a priming signal of ROS-mediated axonal degeneration.
  Experimental Neurology, 352: 114024, 2022.

• Funakoshi M, Araki T.
  Mechanism of initiation and regulation of axonal degeneration with special reference to NMNATs and Sarm1.
  Neuroscience Research, in press.

2021

• Funakoshi M, Araki T.
  Mechanism of initiation and regulation of axonal degeneration with special reference to NMNATs and Sarm1.
  Neuroscience Research, in press.

• Wakatsuki S, Araki T.
  Novel Molecular Basis for Synapse Formation: Small Non-coding Vault RNA Functions as a Riboregulator of MEK1 to Modulate Synaptogenesis.
  Frontiers in Molecular Neuroscience 14: 748721, 2021.

• Nagano S, Araki T.
  Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases.
  Frontiers in Molecular Neuroscience 14: 697973, 2021.

• Seiichi Nagano, Toshiyuki Araki
  Chapter 5: Axonal Transport and Local Translation of mRNA in Amyotrophic Lateral Sclerosis
  In: Araki T, editor. Amyotrophic Lateral Sclerosis. Brisbane (AU): Exon Publications; ISBN: 978-0-6450017-7-8; 2021

• Hagihira H, et al (Wakatsuki S, Araki T as co-authors)
  Systematic analysis of brain lactate and pH levels in 65 animal models related to neuropsychiatric conditions
  bioRxiv 2021.02.02.428362

• Wakatsuki S, Ohno M, Araki T.
  Human vault RNA1-1, but not vault RNA2-1, modulates synaptogenesis.
  Communicative and Integrative Biology, 2021.

• Koike S, Tanaka SC, Okada T, Aso T, Yamashita A, Yamashita O, Asano M, Maikusa N, Morita K, Okada N, Fukunaga M, Uematsu A, Togo H, Miyazaki A, Murata K, Urushibata Y, Autio J, Ose T, Yoshimoto J, Araki T, Glasser MF, Van Essen DC, Maruyama M, Sadato N, Kawato M, Kasai K, Okamoto Y, Hanakawa T, Hayashi T; Brain/MINDS Beyond Human Brain MRI Group.
  Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan
  NeuroImage: Clinical 8:102600, 2021.

• Klionsky DJ, et al. (Wakatsuki S, Araki T as co-authors)
  Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition)
  Autophagy 17(1) 1-382, 2021.

• Wakatsuki S, Takahashi Y, Shibata M, Adachi N, Numakawa T, Kunugi H, Araki T.
  Small non-coding vault RNA modulates synapse formation by amplifying MAPK signaling.
  Journal of Cell Biology. 220(2) e201911078, 2021.

• Uezumi A, Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Nakatani M, Hitachi K, Yamaguchi H, Wakatsuki S, Araki T, Morita M, Yamada H, Toyoda M, Kanazawa N, Nakazawa N, Hino J, Fukada S, Tsuchida K.
  Mesenchymally expressed Bmp3b maintains skeletal muscle integrity and reduction of its expression contributes to sarcopenia.
  Journal of Clinical Investigation. 131(1) e139617, 2021.

2020

• Sasaki-Honda M, Kagita A, Jonouchi T, Araki T, Hotta A, Sakurai H.
  Generation of a transgene-free iPSC line and genetically modified line from a facioscapulohumeral muscular dystrophy type 2 (FSHD2) patient with SMCHD1 p.Lys607Ter mutation.
  Stem Cell Research. 147:101884, 2020.

• Nagano S, Jinno J, Abdelhamid RF, Jin Y, Shibata M, Watanabe S, Hirokawa S, Nishizawa M, Sakimura K, Onodera O, Okada H, Okada T, Saito Y, Takahashi-Fujigasaki J, Murayama S, Wakatsuki S, Mochizuki H, Araki T.
  TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons.
  Acta Neuropathologica. 140(5):695-713, 2020.

• Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE.
  NAD+ repletion rescues female fertility during reproductive aging.
  Cell Reports. Volume 30, February 2020, Pages 1670-1681

• Huang K, Masuda A, Chen G, Bushra S, Kamon M, Araki T, Kinoshita M, Ohkawara B, Ito M, Ohno K.
  Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells.
  Scientific Reports. Volume 10, February 2020, Pages 2558

2019

• Araki T, Yamashita T.
  Mechanism of neuroaxonal degeneration: from molecular signaling to therapeutic applications
  Neuroscience Research Volume 139, February 2019, Pages 1-2

• Araki T, Wakatsuki S.
  Regulation of neuronal/axonal degeneration by ZNRF1 ubiquitin ligase.
  Neuroscience Research Volume 139, February 2019, Pages 21-25

• Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
  Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.
  Neuroscience Research Volume 139, February 2019, Pages 58-62

• Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
  Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
  Neuroscience Research Volume 139, February 2019, Pages 63-68

• Takahashi Y, Uchino A, Shioya A, Sano T, Matsumoto C, Numata-Uematsu Y, Nagano S, Araki T, Murata M, Murayama S, Saito Y.
  Altered immunoreactivity of ErbB4, a causative gene product for ALS19.
  Neuropathology　39: 268-278, 2019.

• Kondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T.
  Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury.
  Scientific Reports 9: 7188 (2019)

• Kondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S,Araki T, Goshima Y, Ohshima T.
  Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury.
  Biochem Biophys Res Commun　514 1037-1039, (2019)

• Tsubota M, Fukuda R, Hayashi Y, Miyazaki T, Ueda S, Yamashita R, Koike N, Sekiguchi F, Wake H, Wakatsuki S, Ujiie Y, Araki T, Nishibori M, Kawabata A.
  Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants.
  J Neuroinflammation 16(1):199, 2019.

• Toshiyuki Araki
  Regulatory Mechanism of Peripheral Nerve Myelination by Glutamate-Induced Signaling.
  Myelin Advances in Experimental Medicine and Biology No.1190 pp 23-31, November, 2019.

2018

• Toshiyuki Araki, Masayoshi Kamon, Hidetoshi Sakurai
  「Disease Modeling and Drug Development with DM1 Patient-Derived iPS Cells」　
  「Myotonic Dystrophy～Disease Mechanism, Current Management and Therapeutic Development」 pp 189-201. Ed by Masanori Takahashi, Tsuyoshi Matsumura.　Springer, 2018

2017

• Galindo R, Greenberg M, Araki T, Sasaki Y, Mehta N, Milbrandt J, Holtzman D.
  NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.
  Annals of Clinical and Translational Neurology. 4(10): 722–738(2017)

• Imai S, Koyanagi M, Azimi Z, Nakazato Y, Matsumoto M, Ogihara T, Yonezawa A, Omura T, Nakagawa S, Wakatsuki S, Araki T, Kaneko S, Matsubara K.
  Taxanes and platinum derivatives impair Schwann cells prior to induction of neurotoxicity via distinct mechanisms.
  Sci Rep 7: 5947 (2017)

• Wakatsuki S, Araki T.
  GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.
  Communicative & Integrative Biology 10 (2) e1296615 (2017)

• Ueki J, Nakamori M, Nakamura M, Nishikawa M, YoshidaY, Tanaka A, Morizane A, Kamon M, Araki T, Takahash MP, Watanabe A, Inagaki N,Sakurai H.
  Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability.
  Sci Rep 7: 42522 (2017)

• Wakatsuki S, Tokunaga S, Shibata M, Araki T.
  GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.
  J Cell Biol 216(2):477-493 (2017)

2016

• Takahashi Y, Kanai M, Taminato T, Watanabe S, Matsumoto C, Araki T, Okamoto T, Ogawa M, Murata M.
  Compound heterozygous intermediate MJD alleles cause cerebellar ataxia with sensory neuropathy.
  Neurol Genet. 3(1): e123 (2016)
• Saito F, Wakatsuki S, Tokunaga S, Araki T.
  Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation.
  Sci. Rep. 6,: 29856 (2016)
• Wakatsuki S, Araki T.
  NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant.
  Communicative & Integrative Biology 9(2) e1143575 (2016)
• Araki,T, Wakatsuki S.
  ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration　
  Atlas of Science. January 11, 2016.
• Nagano S, Araki T
  A cysteine residue is a key commander of SOD1-related neuronal toxicity in ALS.
  Atlas of Science. February 4, 2016
• Seiichi Nagano, Toshiyuki Araki「Role of Cysteine Residue of Mutant Cu, Zn-superoxide Dismutase (SOD1) in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)」
  「Novel Aspects of Amyotrophic Lateral Sclerosis」 page 87-100 Humberto Foyaca Sibat；Lurdes de Fatima Ibanez Valdes Eds;「Update on Amyotrophic Lateral Sclerosis」INTECH（Croatia）2016 ISBN 978-953-51-2601-0

2015

• Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T.
  A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice - Relevance to the pathogenesis of ALS.
  Hum Molec Genet 24(12):3427-39 (2015)
• Wakatsuki S, Furuno A, Ohshima M, Araki T.
  Oxidative stress-dependent phosphorylation activates ZNRF1 ubiquitin ligase to induce neuronal apoptosis and Wallerian degeneration.
  J Cell Biol. 211(4) 881-896 (2015)
• Shuji Wakatsuki, Toshiyuki Araki
  「Significance of Mechanism-Oriented Research Toward Neuronal Protection Therapy Against Neurodegenerative Disorders ~ ZNRF1 E3 Ubiquitin Ligase as a Critical Mediator for Wallerian Degeneration and Neuronal Apoptosis」　
  「Neurodegenerative Disorders as Systemic Diseases 」 pp 159-182. Ed by Keiji Wada　Springer, 2015

2014

• Oie S, Matsuzaki K, Yokoyama W, Tokunaga, S, Waku T, Han SI, Iwasaki N, Mikogai A, Yasuzawa-Tanaka K, Hiyoshi H, Nakajima Y, Araki T, Kimura K, Yanagisawa J, Murayama A.
  Hepatic rRNA Transcription Regulates High-Fat Diet-Induced Obesity.
  Cell Reports 7(3): 807–820 (2014)
• Wakatsuki S, Araki T, Sehara A.
  Neuregulin-1/Glial Growth Factor stimulates Schwann Cell Migration by inducing the alpha5beta1 integrin–ErbB2–Focal Adhesion Kinase Complex Formation.
  Genes Cell 19(1):66-77 (2014)

2013

• Togashi K, Wakatsuki S, Furuno A, Tokunaga S, Nagai Y, Araki, T.
  Na+/H+ exchangers induce autophagy in neurons and inhibit polyglutamine-induced aggregate formation.
  PLoS One 8(11):e81313 (2013)
• Park JY, Jang SY, Shin YK, Koh H, Suh DJ, Tokunaga S, Araki T, Park HT.
  Mitochondrial swelling and microtubule depolymerization are associated with energy depletion in axon degeneration.
  Neuroscience. 238:258-269 (2013)

2012

• Araki T, Nagano S, Tateno M, Kaido M, Ogata K, Arima K.
  Misfolded SOD1 forms high-density molecular complexes with synaptic molecules in mutant SOD1-linked familial amyotrophic lateral sclerosis cases.
  J Neurol Sci. 314(1-2): 92-96 (2012)
• Tokunaga S, Araki T.
  Wallerian degeneration slow mouse neurons are protected against cell death caused by mechanisms involving mitochondrial electron transport dysfunction.
  J Neurosci Res. 90(3):664-671 (2012)

2011

• Wakatsuki S, Saitoh F, Araki T.
  ZNRF1 promotes Wallerian degeneration by degrading Akt to induce GSK3B-dependent CRMP-2 phosphorylation.
  Nature Cell Biol. 13:1415-1423(2011)
• Takada H, Yuasa S, Araki T.
  Demyelination can proceed independently of axonal degradation during Wallerian degeneration in wlds mice.
  Eur J Neurosci. 34:531-537(2011)

2010

• Higashi S, Tsuchiya Y, Araki T, Wada K, Kabuta T.
  TDP-43 physically interacts with Amyotrophic Lateral Sclerosis-Linked mutant Cu/Zn superoxide dismutase.
  Neurochem International. 57:906-913(2010)
• Mitsuhashi H, Hayashi YK, Matsuda C, Noguchi S, Wakatsuki S, Araki T, Nishino I.
  Specific phosphorylation on Ser458 of A-type lamins in LMNA-associated myopathy patients.
  J Cell Sci.　123:3893-3900(2010)
• Saitoh F, Araki T.
  Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation.
  J Neurosci. 30:1204-1212(2010)

2009

• Takada H, Kawana T, Ito Y, Kikuno RF, Mamada H, Araki T,
  Koga H, Asashima M, Taira M.
  The RNA binding protein Mex3b has a fine-tuning system for mRNA regulation in early Xenopus development.
  Development 136:2413-2422, 2009
• Yahata N, Yuasa S, Araki T.
  NMNAT expression in mitochondrial matrix delays Wallerian degeneration.
  J. Neurosci. 29: 6276-6284, 2009
• Wakatsuki S, Yumoto N, Komatsu K, Araki T, Sehara A.
  Roles of meltrin beta/ADAM19 in progression of Schwann cell differentiation and myelination during sciatic nerve regeneration.
  J. Biol.Chem. 284: 2957-2966, 2009
• Tateno M, Kato S, Sakurai T, Nukina N, Takahashi R, Araki T.
  Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3.
  Hum Mol Genet 18: 942-955, 2009

-2007

• Sasaki Y, Araki T, Milbrandt J :
  Stimulation of NAD biosynthetic pathways delays axonal degeneration after axotomy.
  J Neurosci. 26: 8484-8491, 2006.