TOP RESEARCH STAFF PUBLICATIONS ACCESS

A ) 原著 (English only)

2006

Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W: Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibits its ability to produce beta-amyloid protein. Eur. J. Neurosci. 24, 1237-1244, 2006.PubMed (Reticulonタンパクの RTN3 とRTN4-B/CはβセクレターゼBACE1と相互作用し,そのアミロイドβタンパク生成機能を抑制する)
論文の要旨:βセクレターゼBACE1と相互作用するタンパクとしてRTN4-B (Nogo-B)と呼ばれる膜タンパクを同定し,RTN4-B,RTN4-C (Nogo-C),RTN3がBACE1と相互作用することを確認しました。これらのReticulonタンパクはBACE1の酵素触媒ドメイン以外の部分と結合し,アミロイド前駆体タンパクのβ切断を抑え,アミロイドβタンパクの生成量を低下させることを見出しました。従って,RTN4-B/C, RTN3 がBACE1活性の調節に重要な役割を持つことが示唆されます。

Araki W, Saito S, Takahashi-Sasaki N, Shiraishi H, Komano H, Murayama KS: Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif. J. Mol. Neurosci. 29, 35-44, 2006.PubMed (破壊された膜貫通GxxxGモチーフを持つAPH-1変異体の特徴づけ)

Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M: Altered localization of amyloid precursor protein under endoplasmic reticulum stress. Biochem. Biophys. Res. Comm. 344, 525-30, 2006.

Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H: Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex. Genes Cells 11, 83-93, 2006.

2005

Murayama KS, Kametani F, Araki W: Extracellular release of BACE1 holoproteins from human neuronal cells. Biochem. Biophys. Res. Comm. 338, 800-807, 2005.PubMed (ヒト神経系細胞からのBACE1全長タンパクの細胞外放出)

Lakshmana MK, Araki W, Tabira T: Amyloid beta peptide binds a novel death-inducing protein, AB-DIP. FASEB J. 19, 1362-1364, 2005.PubMed (アミロイドβペプチドは新規の細胞死誘導タンパクAB-DIPと結合する)

Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H: Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein. Mol. Brain Res. 137, 70-76, 2005.

Hasegawa T, Ukai W, Jo DG, Xu X, Mattson MP, Nakagawa M, Araki W, Saito T, Yamada T: Homocysteic acid induces intraneuronal accumulation of neurotoxic Ab42: Implications for the pathogenesis of Alzheimer's disease. J. Neurosci. Res. 80, 869-876, 2005.

Saito S, Takahashi-Sasaki N, Araki W: Identification and characterization of a novel human APH-1b splice variant lacking exon 4. Biochem. Biophys. Res. Comm. 330, 1068-1072, 2005.PubMed (エクソン4を欠く新規ヒトAPH-1b変種の同定と特徴づけ)

Saito S, Araki W: Expression profiles of two human APH-1 genes and their roles in the formation of presenilin complexes. Biochem. Biophys. Res. Comm. 327, 18-22, 2005.PubMed (二つのヒトAPH-1遺伝子の発現様式とそれらのプレセニリン複合体形成における役割)

2004

Takeda K, Araki W, Akiyama H, Tabira T: Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain. FASEB J. 18, 1755-1757, 2004.PubMed
論文の要旨: アミロイド前駆体タンパクのカスパーゼ切断がβアミロイドタンパク(Aβ)生成に及ぼす効果を解析し、この切断によりN末を欠いたAβ5-40/42の生成増加がおこること,アルツハイマー病脳には実際にAβ5-40/42が沈着していることなどを世界で初めて示しました。このような特異なAβがアルツハイマー病の病態に重要な役割を持つ可能性があります。

Watanabe N, Araki W, Chui D-H, Makifuchi T, Ihara Y, Tabira T: Glypican-1 as an Abeta binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. FASEB J. 18, 1013-1015, 2004; (FJ express articles) published Apr 14, 2004.PubMed

Takeda K, Araki W, Tabira T: Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2. Eur. J. Neurosci. 19, 258-264, 2004.PubMed



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