TOP RESEARCH STAFF PUBLICATIONS ACCESS

A ) 原著 (English only)

2009

Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein. FEBS J. 276, 5832-5840, 2010.

Kume H, Murayama KS, Araki W: The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1. J. Neurosci. Res. 87, 2963-2972, 2009 PubMed (Reticulonタンパクの2個の疎水性ドメインからなる三次構造がβセクレターゼBACE1の調節に重要である。)

Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T: Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. J. Biol. Chem. 284, 18493-18502, 2009

Kume H, Konishi Y, Murayama KS, Kametani F, Araki W: Expression of reticulon 3 in Alzheimer's disease brain. Neuropathol. Appl. Neurobiol. 35, 178-188, 2009.PubMed (アルツハイマー病脳における Reticulon 3のタンパク発現を生化学的,病理組織学的に解析しました。)

Araki W, Kume H, Oda A, Tamaoka A, Kametani F: IGF-1 promotes beta-amyloid production by a secretase-independent mechanism. Biochem. Biophys. Res. Commun. 380, 111-114, 2009.PubMed (ヒト神経系細胞において, Insulin-like growth factor-1 (IGF-1)がセクレターゼ非依存的メカニズムによりβアミロイド生成を促進することを見い出しました。)

2008

Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T: A family of membrane proteins associated with presenilin expression and gamma-secretase function. FASEB J. 22, 819−827, 2008.PubMed (プレセニリン発現とγセクレターゼ機能に関連する膜蛋白ファミリー(Adoplin-1,2,3/ORMDL-1,2,3)を初めて同定することに成功しました。)

2007

Hoshino T, Nakaya T, Homan T, Tanaka K, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, Mizushima T: Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. J. Biol. Chem. 282, 32676-32688, 2007.

Murayama KS, Kametani F, Tabira T, Araki W: A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein. J. Neurosci. Methods 161, 244-249, 2007. PubMed (カスパーゼ切断されたアミロイド前駆体タンパクから生成するN末端を欠くβアミロイドAβ5-40/42に特異的なモノクローナル抗体)

Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, Mizushima T: Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. Biochem. J. 402, 581-589, 2007.

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