TOP RESEARCH STAFF PUBLICATIONS ACCESS

A ) 原著 (English only)

 

2017

Mamada N, Tanokashira D, Ishii K, Tamaoka A, Araki W: Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein. Biochem Biophys Res Comm 486: 321-328, 2017 PubMed

Tanokashira D, Mamada N, Yamamoto F, Taniguchi K, Tamaoka A, Lakshmana MK, Araki W: The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model. Mol Brain 10:4, 2017 PubMed

NCNPプレスリリース

 

2015

Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W: Amyloid beta-protein oligomers upregulate the beta-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons. Mol Brain 8: 73, 2015  PubMed

NCNPプレスリリース

Tanokashira D, Motoki K, Minegishi S, Hosaka A, Mamada N, Tamaoka A, Okada T, Lakshmana MK, Araki W: LRP1 down-regulates the Alzheimer's beta-secretase BACE1 by modulating its intraneuronal trafficking. eNeuro 2: 0006-15, 2015 PubMed

Araki W, Tamaoka A: Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism. Front Biosci (Landmark Ed), 20, 314-324, 2015 PubMed

2014

Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E: Nardilysin prevents amyloid plaque formation by enhancing a-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging 35(1), 213-222, 2014 PubMed

Araki W, Minegishi S, Motoki K, Kume H, Hohjoh H, Araki YM, Tamaoka A: Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway. Mol Neurobiol 50, 1049-1058, 2014 PubMed (細胞モデルを用いて、TDP-43の疾患関連変異はプロテアソーム経路を介して、そのタンパク代謝回転を促進することを示しました。)

2013

Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin R-W, Tamaoka A, Ogino K: Reduction of beta-amyloid accumulation by reticulon 3 in transgenic mice. Curr Alzheimer Res 10: 135-142, 2013 PubMed(トランスジェニックマウスモデルを用いて、Reticulon3の発現増加がBACE1活性の変調を介して、βアミロイド蓄積を抑制することを明らかにしました。)

Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A: Statins reduce amyloid beta-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. Neurochem Res 38: 589-600, 2013PubMed (スタチンはコレステロール非依存的機序により、アミロイド前駆体タンパクの成熟化、リン酸化の変化を介して、培養神経細胞のβアミロイド産生を低下させることを示しました。)

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