TOP RESEARCH STAFF PUBLICATIONS ACCESS

A ) Original paper

2012

Hayes CD, Dey D, Palavicini JP, Wang H, Araki W, Lakshmana MK: Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice. PLoS ONE 7, e45841, 2012. PubMed

Mutoh T, Kawamura N, Hirabayashi Y, Shima S, Miyashita T, Ito S, Asakura K, Araki W, Cazzaniga E, Muto E, Masserini M: Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis. FASEB J 26(7): 3065-3074, 2012 PubMed

Motoki K, Kume H, Oda A, Tamaoka A, Hosaka A, Kametani F, Araki W: Neuronal beta-amyloid generation is independent of lipid raft association of beta-secretase BACE1: Analysis with a palmitoylation-deficient mutant. Brain and Behavior 2 (3): 270-282, 2012 PubMed

[Using a palmitoylation-deficient mutant of BACE1, we demonstrated that beta-amyloid generation is independent of lipid raft association of the protease in neurons.]

Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J: Autoreactive-Abeta antibodies promote APP beta-secretase processing. J Neurochem 120, 732-740, 2012 PubMed


2011

Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H: ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochim Biophys Acta-General subjects 1810, 790-798, 2011. PubMed

2010

Araki W, Kametani F, Oda A, Tamaoka A: MEK inhibitors suppress beta-amyloid production by altering the level of a beta-C-terminal fragment of amyloid precursor protein in neuronal cells. FEBS Lett. 584, 3410-3414, 2010. PubMed

Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M: Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. J. Biol. Chem. 285, 14920-14931, 2010.

Oda A, Tamaoka A, Araki W: Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. J. Neurosci. Res. 88, 1137-1145, 2010. PubMed

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