TOP RESEARCH STAFF PUBLICATIONS ACCESS

A ) 原著 (English only)

2012

Hayes CD, Dey D, Palavicini JP, Wang H, Araki W, Lakshmana MK: Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice. PLoS ONE 7, e45841, 2012. PubMed

Mutoh T, Kawamura N, Hirabayashi Y, Shima S, Miyashita T, Ito S, Asakura K, Araki W, Cazzaniga E, Muto E, Masserini M: Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis. FASEB J 26(7): 3065-3074, 2012 PubMed

Motoki K, Kume H, Oda A, Tamaoka A, Hosaka A, Kametani F, Araki W: Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: Analysis with a palmitoylation-deficient mutant. Brain and Behavior 2 (3): 270-282, 2012 PubMed
(BACE1のパルミトイル化欠損変異体を用いて、神経細胞のβアミロイド産生はBACE1の脂質ラフト結合とは無関係であることを示しました。)

Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J: Autoreactive-Aβ antibodies promote APP β-secretase processing. J Neurochem 120, 732-740, 2012 PubMed (βアミロイドに対する自己抗体はアミロイド前駆体タンパクのβセクレターゼ切断を促進する)

2011

Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H: ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochim Biophys Acta-General subjects 1810, 790-798, 2011. PubMed

2010

Araki W, Kametani F, Oda A, Tamaoka A: MEK inhibitors suppress beta-amyloid production by altering the level of a beta-C-terminal fragment of amyloid precursor protein in neuronal cells. FEBS Lett. 584, 3410-3414, 2010. PubMed(MEK阻害剤は神経系細胞において,βアミロイド前駆体蛋白のC末断片のレベルを変化させることにより,βアミロイド産生を抑制する)

Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M: Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. J. Biol. Chem. 285, 14920-14931,2010.

Oda A, Tamaoka A, Araki W: Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. J. Neurosci. Res. 88,1137-1145, 2010. PubMed (酸化ストレスは神経系細胞の脂質ラフトにおいてプレセニリン1発現を促進する)

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