National Institute of Neuroscience, NCNP
Department of Biochemistry & Cellular Biology
(Hoshino Lab)
Previous publications of Dr. Inoue are listed here
final update -Jan 20, 2012
Original Articles
2012
Bjerknes M, Khandanpour C, Moroy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martin MG, Chen H:
Origin of the brush cell lineage in the mouse intestinal epithelium.
Dev Biol, 362, 194-218, 2012
2011
Morinaka A, Yamada M, Itofusa R, Funato Y, Yoshimura Y, Nakamura F, Yoshimura T, Kaibuchi K, Goshima Y, Hoshino M, Kamiguchi H, Miki H:
Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse.
Sicence Signaling, 4 (170), ra26, 2011
Goto A, Hoshino M , Matsuda M, Nakamura T:
Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells.
Mol BIol Cell, 22, 1780-1790, 2011
Komine O, Nagaoka M, HIraoka Y, Hoshino M, Kawaguchi Y, Pear WS, Tanaka K:
RBP-J promotes the maturation of neuronal progenitors.
Dev Biol, 354, 44-54, 2011
Matsumoto A, Susaki E, Onoyama I, Nakayama K, Hoshino M, Nakayama KI:
Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice.
Mol Cell Biol, 31, 4176-4192, 2011
2010
Kawauchi T, Sekine K, Shikanai M, Chihama K, Tomita K, Nakajima K, Nabeshima Y, Hoshino M:
Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-Cadherin trafficking.
Neuron, 67, 588-602, 2010
Nishida K, Hoshino M, Kawaguchi Y, Murakami F:
Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system.
J. Biol. Chem. 285, 373-380, 2010
Nishimura YV, Sekine K, Chihama K, Nakajima K, *Hoshino M, Nabeshima Y, *Kawauchi T:
Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex.
J. Biol. Chem. 285, 5878-5887, 2010
Iritani S, Sekiguchi H, Habuchi C, Hikita T, Taya S, Kaibuchi K, Ozaki N:
Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal region of genetic animal model of schizophrenia.
Synapse, 64, 948-953, 2010
Miyahara K, Kato Y, Koga H, Lane GJ, Inoue T, Akazawa C, Yamataka, A:
Abnormal enteric innervation identified without histopathologic staining in aganglionic colorectum from a mouse model of Hirschsprung's disease.
J Pediatr Surg. 45:2403-2407, 2010.
Shibata S, Yasuda A, Renault-Mihara F, Suyama S, Katoh H, Inoue T, Inoue YU, Nagoshi N, Sato M, Nakamura M, Akazawa C, Okano H:
Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes.
Mol. Brain 3:31, 2010
2009
Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue YU, Inoue T, Masuyama N, Obata K, Yanagawa Y, Kawaguchi Y, Nabeshima Y, Hoshino M:
Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1.
Development, 136, 2049-2058, 2009
Causeret F, Terao M, Jacobs T, Nishimura YV, Yanagawa Y, Obata K, Hoshino M, Nikolic M:
The p21-activated kinase is required for neuronal migration in the cerebral cortex.
Cerebral Cortex, 19, 861-875, 2009
Inoue YU, Asami J, Inoue T:
Genetic labeling of mouse rhombomeres by Cadherin-6::EGFP-BAC transgenesis underscores the role of cadherins in hindbrain compartmentalization.
Neurosci. Res., 63, 2-9, 2009
Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, OkazawaH, Nabeshima Y:
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
PloS ONE, 4, e4466, 2009
Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J, Scofield MA, Dowd FJ, Lin M-F, Tu Y:
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.
Oncogene, 28, 1853-1863, 2009
Cao Y, Masuho I, Okawa H, Xie K, Asami J, Kammermeier PJ, Maddox DM, Furukawa T, Inoue T, Sampath AP, Martemyanov KA:
Retina specific GTPase accelerator RGS11/Gb5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons.
J. Neurosci. 29, 9301-9313, 2009
Ono K, Nakagawa T, Kojima K, Matsumoto M, Kawauchi T, Hoshino M, Ito J:
Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae.
Mol Cell Neurosci. 42, 391-398, 2009
Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M. Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Neuron, 63, 774-787, 2009
Hikita T, Taya S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K:
Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein.
J. Neurochem., 110, 1567-1574, 2009
Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, Taya S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H:
Association analysis between schizophrenia and the AP-3 complex genes.
Neurosci. Res., 65, 113-115, 2009
Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A, Ménager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K:
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.
Dev. Cell, 16, 675-686, 2009
Taneichi-Kuroda S, Taya S, Hikita T, Fujino Y, Kaibuchi K:
Direct interaction of Dysbindin with the AP-3 complex via its mu subunit.
Neurochem. Int., 54, 431-438, 2009
Inoue T, Inoue YU, Asami J, Izumi H, Nakamura S, Krumlauf R:
Analysis of mouse Cdh6 gene regulation by transgenesis of modified bacterial artificial chromosomes.
Dev Biol, 315, 506-520, 2008
Fukuda A, Kawaguchi Y, Furuyama F, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CVE, Hoshino M, Chiba T, Uemoto S:
Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes mellitus in mice.
Diabetes, 57, 2421-2431, 2008
Masuho I, Mototani Y, Sahara Y, Asami J, Nakamura S, Kozasa T, Inoue, T:
Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Gao implicate significant roles of Gao-GRIN1 signaling in nervous system.
Dev. Dyn. 237, 2415-2429, 2008
Inoue YU, Asami J, Inoue T:
Cadherin-6 gene regulatory patterns in the postnatal mouse brain.
Mol. Cell. Neurosci., 39, 95-104, 2008.
Kumanogoh H, Asami J, Nakamura S, Inoue T.
Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system.
Mol Cell Neurosci. 39, 465-477, 2008
Tsuda R, Kumanogoh H, Umeda M, Maekawa S.
Morphological analysis on the distribution of membrane lipids and a membrane protein, NAP-22, during neuronal development in vitro.
J Mol Histol. 39, 371-379. 2008
Masutani T, Taguchi K, Kumanogoh H, Nakamura S, Maekawa S.
Molecular interaction of neurocalcin alpha with alsin (ALS2).
Neurosci. Lett. 438, 26-28, 2008
Maimaitiyiming M, Kumanogoh H, Nakamura S, Nagata K, Suzaki T, Maekawa S.
Biochemical characterization of membrane-associated septin from rat brain.
J Neurochem. 106, 1175-1183, 2008
2007
Yamada M, Terao M, Terashima T, Fujiyama T, Kawaguchi Y, Nabeshima Y, Hoshino M:
Origin of climbing fiber neurons and their developmental dependence on Ptf1a.
J. Neurosci., 27, 10924-10934, 2007)
Takemoto-Kimura S, Ishihara-Ageta N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H, Bito H:
Regulation of dendritogenesis via a lipid raft-associated Ca2+/calmodulin-dependent proteini kinase CLICK-III/CaMKIg,
Neuron, 54, 755-770, 2007
Shima Y, Kawaguchi SY, Kosaka K, Nakayama M, Hoshino M, Nabeshima Y, Hirano T, Uemura T:
Opposing roles in neurite growth control by two 7-pass transmembrane cadherins.
Nature Neuroscience, 10, 963-969, 2007
Jacobs T, Causeret F, Nishimura YV, Terao M, Norman A, Hoshino M, Nikolic M:
Localized activation of Pak1 controls neuronal polarity and morphology.
J. Neurosci., 27, 8604-8615, 2007
(Selected in “This week in the journal”)
Causeret F, Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M:
Neurabin-I is phosphorylated by Cdk5: implications for neuronal morphogenesis and cortical migration.
Molecular Biol. Cell, 18, 4327-4342, 2007
Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, Bokoch GM:
Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function
J. Leukocyte Biol., 81, 1127-1136, 2007
Takefuji M, Mori K, Morita Y, Arimura N, Nishimura T, Nakayama M, Hoshino M, Iwamatsu A, Murohara T, Kaibuchi K, Amano M:
Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation
Biochem. Biophys. Res. Comm., 355, 788-794, 2007
ZalduaN , Gastineau M, Hoshino M, Lezoualc'h F, Zugaza JL:
Epac signaling pathway involves STEF a guanine nucleotide exchange factor for Rac to regulate APP processing.
FEBS Letter 581, 5814-5818, 2007
2006
Kawauchi T, Chihama K, Nabeshima Y, Hoshino M:
Cdk5 phosphorylates and stabilizes p27kip1, contributing to actin organization and cortical neuronal migration.
Nature Cell Biol. 8, 17-26, 2006
（Highlighted by News & Views）
2005
Yoshizawa M, Kawauchi T, Sone M, Nishimura YV, Terao M, Chihama K, Nabeshima Y, Hoshino M:
Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration.
J. Neurosci. 25, 4406-4419, 2005
Kawauchi T, Chihama K, Nishimura YV, Nabeshima Y, Hoshino M:
MAP1B phosphorylation is differentially regulated by Cdk5/p35, Cdk5/p25 and JNK.
Biochem. Biophys. Res. Comm., 331, 50-55, 2005
Dezawa M, Ishikawa H, Itokazu Y, Yoshihara T, Hoshino M, Takeda S, Ide C, Nabeshima Y:
Bone marrow stromal cells generate muscle cells and repair muscle degeneration.
Science, 309, 314-317 (2005)
Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuch K: PAR-6-PAR-3 mediates Cdc42 signaling to Rac activation through STEF/Tiam1, RacGEFs.
Nature Cell Biol. 7, 270-277, 2005
2004
Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, Tajima N, Yamada H, Sawada H, Ishikawa H, Mimura T, Kitada M, Suzuki Y, Ide C:
Specific induction of neuronal cells from bone-marrow stromal cells and application for autologous transplantation.
J. Clin. Invest., 113, 1701-1710, 2004
2003
Kawauchi T, Chihama K, Nabeshima Y, Hoshino M:
The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration.
EMBO Journal, 22, 4190-4201, 2003
Yoshizawa M, Sone M, Matsuo N, Nagase T, Ohara O, Nabeshima Y, Hoshino M:
Dynamic and coordinated expression profiles of Dbl-family guanine nucleotide exchange factors in the developing mouse brain.
Gene Expression Patterns, 3, 375-381, 2003
Matsuo N, Terao M, Nabeshima Y, Hoshino M:
Roles of STEF/Tiam1, guanine necleotide exchange factors for Rac1, in regulation of growth cone morphology.
Mol. Cell. Neurosci., 24, 69-81, 2003
Selected as a cover of the journal.
2002
Yoshizawa M, *Hoshino M, Sone M, Nabeshima Y:
Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain.
Mech. Dev., 113, 65-68, 2002 (*corresponding author)
Matsuo M, *Hoshino M, Yoshizawa Y, Nabeshima Y:
Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth.
J. Biol. Chem. 277, 2860-2868, 2002 (*corresponding author)
~ 2000
Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C:
Synaptic development is controlled in the periactive zones of Drosophila synapses.
Development, 127, 4157-4168, 2000
Hoshino M, Sone M, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C:
Identification of the stef gene that encodes a novel guanine-nucleotide exchange factor specific for Rac1.
J. Biol. Chem., 274, 17837-17844, 1999
Hoshino M, Suzuki E, Miyake T, Sone M, Komatsu A, Nabeshima Y, Hama C:
Neural expression of Hikaru genki protein during embryonic and larval development of Drosophila melanogaster
Dev. Genes Evol., 209, 1-9, 1999
Sone M, Hoshino M, Suzuki E, Kuroda S, Kaibuchi K, Nakagoshi H, Saigo K, Nabeshima Y, Hama C:
Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers.
Science, 275, 543-547, 1997
Hoshino M, Suzuki E, Nabeshima Y, Hama C:
Hikaru genki protein is secreted into synaptic clefts from an early stage of synapse formation in Drosophila
Development, 122, 589-597, 1996
Hoshino M, Matsuzaki F, Nabeshima Y, Hama C:
hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein
Neuron, 10, 395-407, 1993
Review Articles & Books
Hori K, Hoshino M:
GABAergic neuron specification in the spinal cord, the cerebellum and the cochlear nucleus
Neural Plasticity , in press
Hoshino M:
Neuronal subtype specification in the cerebellum and dorsal hindbrain.
Dev Growth Differ, in press
Hoshino M, Seto Y, Yamada M:
Specification of cerebellar and precerebellar neurons: HANDBOOK OF THE CEREBELLUM AND CEREBELLAR DISORDERS, Springer, in press
Kawauchi T, Hoshino M:
Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons
Developmental Neuroscience, 30, 36-46, 2008
Hoshino M:
Molecular machinery governing GABAergic neuron specification in the cerebellum.
The Cerebellum, 5, 193-198, 2006
Dezawa M, Hoshino M, Ide C:
Treatment of neurodegenerative diseases using adult bone marrow stromal cell-derived neurons.
Expert Opinion on Biological Therapy, 5, 427-435, 2005
Dezawa M, Hoshino M, Nabeshima Y, Ide C:
Marrow stromal cells: implications in health and disease in the nervous system.
Current Molecular Medicine, 5, 653-662, 2005
Dezawa M, Ishikawa H, Hoshino M, Itokazu Y, Nabeshima Y:
Potential of bone marrow stromal cell in application to neurodegenerative and muscle degenerative diseases.
Current Neuropharmacology 3, 257-266, 2005