研 究 業 績
著書へ 総説へ
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原 著
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2011
Yokota T, Hoffman E, Takeda S：Antisense oligo-mediated multiple exon skipping in a dog model of duchenne muscular dystrophy. Methods Mol Biol. 709:299-312, 2011
Lu QL, Yokota T, Takeda S, Garcia L, Muntoni F, Partridge T：The status of exon skipping as a therapeutic approach to duchenne muscular dystrophy. Mol Ther. 19:9-15, 2011
Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H: SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses. J Neurochem. doi: 10.1111/j.1471-4159.2010.07167.x, 2011
Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H：Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle. Cell Metab. 13:170-82, 2011
Nakamura A, Takeda S：Mammalian models of duchenne muscular dystrophy: pathological characteristics and therapeutic applications. J Biomed Biotechnol. 2011;2011:184393. Epub 2011 Jan 5.
Shin, J.H, Nitahara-Kasahara, Y, Hayashita-Kinoh, H, Ohshima, S, Kinoshita, K, Chiyo T, Okada, H, Okada, T, Takeda, S: Improvement of cardiac fibrosis in dystrophic mice by rAAV9-mediated microdystrophin transduction. Gene Ther. (in press)
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2010
Aoki Y, Nakamura A, Yokota T, Saito T, Okazawa H, Nagata T, Takeda S：In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse. Mol Ther. 18, 1995-2005, 2010
Miyagoe-Suzuki Y, Takeda S: Gene therapy for muscle disease. Exp Cell Res. 316: 3087-3092, 2010
Yajima H, Motohashi N, Ono Y, Sato S, Ikeda K, Masuda S, Yada E, Kanesaki H, Miyagoe-Suzuki Y, Takeda S, Kawakami K: Six family genes control the proliferation and differentiation of muscle satellite cells. Exp Cell Res. 316: 2932-2944, 2010
Kanagawa M, Omori Y , Sato S, Kobayashi K, Miyagoe-Suzuki Y, Takeda S, Endo T, Furukawa T, Toda T: Post-translational Maturation of Dystroglycan Is Necessary for Pikachurin Binding and Ribbon Synaptic Localization. J Biol Chem. 285:31208-31216, 2010
Saito T, Nakamura A, Aoki Y, Yokota T, Okada T, Osawa M, Takeda S: Antisense PMO Found in Dystrophic Dog Model Was Effective in Cells from Exon 7-Deleted DMD Patient. PLoS One.;5(8). pii: e12239, 2010
Suzuki N, Mizuno H, Warita H, Takeda S, Itoyama Y, Aoki M: Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis. J Neurol Sci. 294: 95-101, 2010
Fukada S, Morikawa D, Yamamoto Y, Yoshida T, Sumie N, Yamaguchi M, Ito T, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H: Genetic background affects properties of satellite cells and mdx phenotypes. Am J Pathol. 176: 2414-2424, 2010
Masamizu Y, Okada T, Ishibashi H, Takeda S, Yuasa S, Nakahara K: Efficient gene transfer into neurons in monkey brain by adeno-associated virus 8. Neuroreport. 21:447-451, 2010
Uezumi A, Fukuda S, Yamamoto N, Takeda S, Tsuchida K: Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol 12: 143-152, 2010
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2009
Matsumoto H, Maruse H, Sasazaki S, Fujiwara A, S Takeda, Ichihara N, Kikuchi T, Mukai F, Mannen H: Expression pattern of WWP1 in muscular dystrophic and normal chickens. J. Poult. Sci. 46: 95-99, 2009
Kobayashi M, Nakamura A, Hasegawa D, Fujita M, Orima H, Takeda S: Evaluation of dystrophic dog pathology by fat-suppressed T2-weighted imaging. Muscle Nerve.40: 815-826, 2009
Cui R, Duan XL, Anderson GJ, Qiao YT, Yu P, Qian ZM, Yoshida K, Takeda S, Guo P, Yang ZL, Chang YZ : Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice. J Trace Elem Med Biol. 23: 290-299, 2009
Guo P, Cui R, Chang YZ, Wu WS, Qian ZM, Yoshida K, Qiao YT, Takeda S, Duan XL: Hepcidin, an antimicrobial peptide is downregulated in ceruloplasmin-deficient mice. Peptides. 30: 262-266, 2009
Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa ; A, Sakamoto K, Yamaguchi A: CCN3 and bone marrow cells. J Cell Commun Signal. 3: 135-145, 2009
Okada T, Nonaka-Sarukawa M, Uchibori R, Kinoshita K, Hayashita-Kinoh H, Nitahara-Kasahara Y, Takeda S, Ozawa K: Scalable purification of AAV1 and AAV8 vectors using dual ion-exchange adsorptive membranes. Hum Gene Ther.20: 1013-1021, 2009
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T: Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading. Mol Cell Biol. 17: 4798-4811, 2009
Nakamura A, Takeda S: Exon-skipping therapy for Duchenne muscular dystrophy. Neuropathology. 29: 494-501, 2009
Uchibori R, Okada T, Ito T, Urabe M, Mizukami H, Kume A, Ozawa K: Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy. J Gene Med. 11: 373-381, 2009
Yokota T, Lu QL, Partridge T, Kobayashi M, Nakamura A, Takeda S, Hoffman E: Efficacy of systemic morpholino exon-skipping in duchenne dystrophy dogs. Ann Neurol 65: 667-676, 2009
Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada SI, Yamamoto H, Motohashi N, Suzuki Y, Takeda S, Heike T, Nakahata T: Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells. FASEB J 23: 1907-1919, 2009
Yokota T, Takeda S, Lu QL, Partridge TA, Nakamura A, Hoffman EP: A renaissance for antisense oligonucleotide drugs in neurology: exon skipping breaks new ground. Arch Neurol 66: 32-38, 2009
Miyazaki D, Yoshida K, Fukushima K, Nakamura A, Suzuki K, Sato T, Takeda S, Ikeda S: Characterization of deletion breakpoints in patients with dystrophinopathy carrying a deletion of exons 45-55 of the Duchenne muscular dystrophy (DMD) gene. J Hum Genet 54: 127-130, 2009
Miyagoe-Suzuki Y, Masubuchi N, Miyamoto K, Wada MR, Yuasa S, Saito F, Matsumura K, Kanesaki H, Kudo A, Manya H, Endo T, Takeda S: Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro. Mech Dev 126: 107-116, 2009
Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T: Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy. Hum Mol Genet 18: 621-31, 2009
Sekiguchi M, Zushida K, Yoshida M, Maekawa M, Kamichi S, Yoshida M, Sahara Y, Yuasa S, Takeda S, Wada K: A deficit of brain dystrophin impairs specific amygdala GABAergic transmission and enhances defensive behaviour in mice. Brain 132: 124-135, 2009
Ohshima S, Shin JH, Yuasa K, Nishiyama A, Kira J, Okada T, Takeda S: Transduction Efficiency and Immune Response Associated With the Administration of AAV8 Vector Into Dog Skeletal Muscle. Mol Ther 17: 73-80, 2009
Shibuya N, Tanaka M, Yoshida M, Ogasawara Y, Togawa T, Ishii K and Kimura H: 3-mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal 11: 703-714, 2009
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2008
Segawa M, Fukada S, Yamamoto Y, Yahagi H, Kanematsu M, Sato M, Ito T, Uezumi A, Hayashi S, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H: Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis. Exp Cell Res 314: 3232-3244, 2008
Yuasa K, Hagiwara Y, Ando M, Nakamura A, Takeda S, Hijikata T: MicroRNA-206 is highly expressed in newly formed muscle fibers: implications regarding potential for muscle regeneration and maturation in muscular dystrophy. Cell Struct Funct 33: 163-169, 2008
Katsumata O, Honma T, Sanda M, Kamata A, Takeda S, Kondo H, Sakagami H: Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes. Brain Res 1234:44-49, 2008
Motohashi N, Uezumi A, Yada E, Fukada S, Fukushima K, Imaizumi K, Miyagoe-Suzuki, Y, Takeda S: Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts. Am J Pathol 173: 781-791, 2008
Sato K, Yokota T, Ichioka S, Shibata M, Takeda S: Vasodilation of intramuscular arterioles under shear stress in dystrophin-deficient skeletal muscle is impaired through decreased nNOS expression. Acta Myol 27:30-36, 2008
Nishiyama A, Ampong BN, Ohshima S, Shin JH, Nakai H, Imamura M, Miyagoe-Suzuki Y, Okada T, Takeda S: Recombinant adeno-associated virus type 8-mediated extensive therapeutic gene delivery into skeletal muscle of alpha-sarcoglycan-deficient mice. Hum Gene Ther 19: 719-730, 2008
Nakamura A, Yoshida K, Fukushima K, Ueda H, Urasawa N, Koyama J, Yazaki Y, Yazaki M, Sakai T, Haruta S, Takeda S, Ikeda S: Follow-up of three patients with a large in-frame deletion of exons 45-55 in the Duchenne muscular dystrophy (DMD) gene. J Clin Neurosci 15: 757-763, 2008
Hijikata T, Nakamura A, Isokawa K, Imamura M, Yuasa K, Ishikawa R, Kohama K,@Takeda S, Yorifuji H: Plectin 1 links intermediate filaments to costameric sarcolemma through {beta}-synemin, {alpha}-dystrobrevin and actin. J Cell Sci 121: 2062-2074, 2008
Matsumoto H, Maruse H, Inaba Y, Yoshizawa K, Sasazaki S, Fujiwara A, Nishibori M, Nakamura A, Takeda S, Ichihara N, Kikuchi T, Mukai F, Mannen H: The ubiquitin ligase gene (WWP1) is responsible for the chicken muscular dystrophy. FEBS Lett 582: 2212-2218, 2008
Urasawa N, Wada MR, Machida N, Yuasa K, Shimatsu Y, Wakao Y, Yuasa S, Sano T, Nonaka I, Nakamura A, Takeda S: Selective vacuolar degeneration in dystrophin deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. Circulation 117: 2437-2448, 2008
Tanihata J, Suzuki N, Miyagoe-Suzuki Y, Imaizumi K, Takeda S: Dowmstream utrophin enhancer is required for expression of utrophin in skeletal muscle. J Gene Med 10: 702-713, 2008
Nakatani M, Takehara Y, Sugino H, Matsumoto M, Hashimoto O, Hasegawa Y, Murakami T, Uezumi A, Takeda S, Noji S, Sunada Y, Tsuchida K: Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice. FASEB J 22: 477-487, 2008
Yuasa K, Nakamura A, Hijikata T, Takeda S: Dystrophin deficiency in canine X-linked muscular dystrophy in Japan (CXMDJ) alters myosin heavy chain expression profiles in the diaphragm more markedly than in the tibialis cranialis muscle. BMC Musculoskelet Disord 9: 1, 2008
Fukada S, Yamamoto Y, Segawa M, Sakamoto K, Nakajima M, Sato M, Morikawa D, Uezumi A, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H: CD90-positive cells, an additional cell population, produce laminin <alpha>2 upon transplantation to dy3k/dy3k mice. Exp Cell Res 314: 193-203, 2008
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2007
Suzuki N, Motohashi N, Uezumi A, Fukada SI, Yoshimura T, Itoyama Y, Aoki M, Miyagoe-Suzuki Y, Takeda S. NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS. J Clin Invest.117(9): 2468-2476, 2007
Ikemoto M, Fukada SI, Uezumi A, Masuda S, Miyoshi H, Yamamoto H, Wada MR, Masubuchi N, Miyagoe-Suzuki Y, Takeda S. Autologous Transplantation of SM/C-2.6(+) Satellite Cells Transduced with Micro-dystrophin CS1 cDNA by Lentiviral Vector into mdx Mice. Mol Ther. 15(12): 2178-85, 2007
Fukada S, Uezumi A, Ikemoto M, Masuda S, Segawa M, Tanimura N, Yamamoto H, Miyagoe-Suzuki Y, Takeda S. Molecular Signature of Quiescent Satellite Cells In Adult Skeletal Muscle. Stem Cells 25(10): 2448-2459, 2007
Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Harada N, Hosaka T, Na kaya Y, Ishidoh K, Obata T, Ebina Y, Gu H, Takeda S, Kishi K, Nikawa T. Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes 56(10): 2511-2522, 2007
Yuasa K, Yoshimura M, Urasawa N, Ohshima S, Howell JM, Nakamura A, Hijikata T, Miyagoe-Suzuki Y, Takeda S. Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products. Gene Ther. 14(17): 1249-1260, 2007
Fukushima K, Nakamura A, Ueda H, Yuasa K, Yoshida K, Takeda S, Ikeda SI. Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ).BMC Musculoskelet Disord. 8(1): 54
Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, Takahashi T, Goto M, Mikami Y, Yasuda N, Akazawa H, Uezumi A, Takeda S, Komuro I. Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol. 176(3): 329-341, 2007
Ideno J, Mizukami H, Kakehashi A, Saito Y, Okada T, Urabe M, Kume A, Kuroki M, Kawakami M, Ishibashi S, Ozawa K: Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model. Int J Mol Med 19 (1): 75-79, 200
Takei Y, Mizukami H, Saga Y, Yoshimura I, Hasumi Y, Takayama T, Kohno T, Matsushita T, Okada T, Kume A, Suzuki M, Ozawa K: Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector. Int J Cancer 120 (2): 278-284, 2007
Nakata M, Okada T, Ozawa K, Yada T: Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochem Biophys Res Commun 353 (4): 1046-1051, 2007
Liu Y, Okada T, Nomoto T, Ke X, Kume A, Ozawa K, Xiao S: Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo. Exp Mol Med. 39 (2): 170-175, 2007
Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K: Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats. Circ Res. 101 (7): 734-741, 2007
Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Sakata Y, Shimada K, Ozawa K: Adeno associated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. Hypertension 50 (3): 531-536, 2007
Kobayashi M, Okada T, Murakami T, Ozawa K, Kobayashi E Morita T: Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems. Urology 70 (6): 1230-1236, 2007
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2006
Yugeta N, Urasawa N, Fujii Y, Yoshimura M, Yuasa K, Nakamura A, Wada MR, Nakura M, Shimatsu Y, Tomohiro M,Takahashi A, Machida N, Wakao Y, Takeda S. Cardiac involvement in Beagle-based canine X-linked muscular dystrophy in Japan (CXMDJ): electrocardiographic, echocardiographic, and morphologic studies. BMC Cardiovasc Disord. 6: 47, 2006
Pramono ZA, Lai PS, Tan CL, Takeda S, Yee WC. Identification and characterization of a novel human dysferlin transcript: dysferlin_v1. Hum Genet. 120 (3): 410-419, 2006
Yokota T, Lu QL, Morgan JE, Davies KE, Fisher R, Takeda S, Partridge TA. Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration. J Cell Sci. 119 (Pt 13): 2679-2687, 2006
Suzue N, Nikawa T, Onishi Y, Yamada C, Hirasaka K, Ogawa T, Furochi H, Ksaka H, Ishidoh K, Gu H, Takeda S, Ishimaru N, Hayashi Y. Yamamoto H, Kishi K, Yasui N: Ubiquitin ligase Cbl-b down-regulate bone formation through supression of OGF-1 signaling in osteblasts during denervation. J Bone Miner Res. 21(5): 722-734, 2006
Shiga K, Yoshioka H, Matsumiya T, Kimura I, Takeda S, Imamura M. zeta-Sarcoglycan is a functional homologue of gamma-sarcoglycan in the formation of the sarcoglycan complex. Exp Cell Res. 312 (11): 2083-2092, 2006
Uezumi A, Ojima K, Fukada S, Ikemoto M, Masuda S, Miyagoe-Suzuki Y, Takeda S. Functional heterogeneity of side population cells in skeletal muscle. Biochem Biophys Res Commun 341: 864-873, 2006
Hagiwara Y, Fujita M, Imamura M, Noguchi S, Sasaoka T： Caveolin-3 deficiency decreases the gene expression level of osteopontin in mdx mouse skeletal muscle. Acta Myol. 25, 53-61, 2006
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2005
Okano T, Yoshida K, Nakamura A, Sasazawa F, Oide T, Takeda S, Ikeda S. Chronic exercise accelerates the degeneration-regeneration cycle and downregulates insulin-like growth factor-1 in muscle of mdx mice. Muscle Nerve 32 (2): 191-199, 2005
Dezawa M, Ishikawa H, Itokazu Y, Yoshihara T, Hoshino M, Takeda S, Ide C, Nabeshima Y. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 309 (5732): 314-317, 2005
Nakamura A, Yoshida K, Ueda H, Takeda S, Ikeda S. Up-regulation of mitogen activated protein kinases in mdx skeletal muscle following chronic treadmill exercise. Biochim Biophys Acta. 1740 (3): 326-331, 2005
Mochizuki Y, Ojima K, Uezumi A, Masuda S, Yoshimura K, Takeda S. Participation of bone marrow-derived cells in fibrotic changes in denervated skeletal muscle. Am J Pathol. 166 (6): 1721-1732, 2005
Yang D, Bierman J, Tarumi YS, Zhong YP, Rangwala R, Proctor TM, Miyagoe-Suzuki Y, Takeda S, Miner JH, Sherman LS, Gold BG, Patton BL. Coordinate control of axon defasciculation and myelination by laminin-2 and -8. J Cell Biol. 168 (4): 655-666, 2005
Imamura M, Mochizuki Y, Engvall E, Takeda S. {epsilon}-Sarcoglycan compensates for lack of {alpha}-sarcoglycan in a mouse model of limb-girdle muscular dystrophy. Hum Mol Genet. 14 (6): 775-783, 2005
Takahashi J, Itoh Y, Fujimori K, Imamura M, Wakayama Y, Miyagoe-Suzuki
Y, Takeda S. The utrophin promoter A drives high expression of the transgenic
LacZ gene in liver, testis, colon, submandibular gland, and small intestine.
J Gene Med. 7 (2): 237-248, 2005
Lu QL, Rabinowitz A, Chen YC, Yokota T, Yin H, Alter J, Jadoon A, Bou-Gharios G, Partridge T. Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles. Proc Natl Acad Sci U S A. 102 (1): 198-203, 2005
Shimatsu Y, Yoshimura M, Yuasa K, Urasawa N, Tomohiro M, Nakura M, Tanigawa M, Nakamura A, Takeda S: Major clinical and histopathological characteristics of canine X-linked muscular dystrophy in Japan, CXMDJ. Acta Myologica XXIV: 145-154, 2005
Ampong BN, Imamura M, Matsumiya T, Yoshida M, Takeda S: Instracellular localization of dysferlin and its association with the dihydropyridine receptor. Acta Myologica XXIV: 134-144, 2005
Hoshino Y, Uchida M, Shimatsu Y, Miyake M, Nagao Y, Minami N, Yamada M, Imai H: Developmental competence of somatic cell nuclear transfer embryos reconstructed from oocytes matured in vitro with follicle shells in miniature pig. Cloning Stem Cells 7: 17-26, 2005
Ozawa E, Mizuno Y, Hagiwara Y, Sasaoka T, Yoshida M: Molecular and cell biology of the sar coglycan complex. Muscle Nerve 32: 563-576, 2005
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2004
Yoshimura M, Sakamoto M, Ikemoto M, Mochizuki Y, Yuasa K, Miyagoe-Suzuki Y, Takeda S. AAV vector-mediated microdystrophin expression in a relatively small percentage of mdx myofibers improved the mdx phenotype. Mol Ther. 10 (5): 821-828, 2004
Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T. Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. J Alzheimers Dis. 6 (5): 483-488, 2004
Ojima K, Uezumi A, Miyoshi H, Masuda S, Morita Y, Fukase A, Hattori A, Nakauchi H, Miyagoe-Suzuki Y, Takeda S. Mac-1(low) early myeloid cells in the bone marrow-derived SP fraction migrate into injured skeletal muscle and participate in muscle regeneration. Biochem Biophys Res Commun. 2004 321 (4): 1050-1061, 2004
Gawlik K, Miyagoe-Suzuki Y, Ekblom P, Takeda S, Durbeej M. Laminin alpha1 chain reduces muscular dystrophy in laminin alpha2 chain deficient mice. Hum Mol Genet. 13 (16): 1775-1784, 2004
Nishiyama A, Endo T, Takeda S, Imamura M. Identification and characterization of epsilon-sarcoglycans in the central nervous system. Brain Res Mol Brain Res. 125 (1-2): 1-12. 2004
Fukada S, Higuchi S, Segawa M, Koda K, Yamamoto Y, Tsujikawa K, Kohama Y, Uezumi A, Imamura M, Miyagoe-Suzuki Y, Takeda S, Yamamoto H. Purification and cell-surface marker characterization of quiescent satellite cells from murine skeletal muscle by a novel monoclonal antibody. Exp Cell Res. 296 (2): 245-255, 2004
Yuasa K, Fukumoto S, Kamasaki Y, Yamada A, Fukumoto E, Kanaoka K, Saito K, Harada H, Arikawa-Hirasawa E, Miyagoe-Suzuki Y, Takeda S, Okamoto K, Kato Y, Fujiwara T. Laminin alpha2 is essential for odontoblast differentiation regulating dentin sialoprotein expression. J Biol Chem. 279 (11): 10286-10292, 2004.
Munehira Y, Ohnishi T, Kawamoto S, Furuya A, Shitara K, Imamura M, Yokota T, Takeda S, Amachi T, Matsuo M, Kioka N, Ueda K: Alpha1-syntrophin modulates turnover of ABCA1. J Biol Chem. 279 (15): 15091-15095, 2004
Nikawa T, Ishidoh K, Hirasaka K, Ishihara I, Ikemoto M, Kano M, Kominami
E, Nonaka I, Ogawa T, Adams G, Baldwin K, Yasui N, Kishi K, Takeda S: Skeletal
muscle gene expression in space-flown rats. FASEB J. 18 (3): 522-524,2004
Ishikawa-Sakurai M, Yoshida M, Imamura M, Davies KE, Ozawa E: ZZ domain is essentially required for the physiological binding of dystrophin and utrophin to beta-dystroglycan. Hum Mol Genet 13: 693-702, 2004
Mizuno Y, Guyon JR, Watkins SC, Mizushima K, Sasaoka T, Imamura M, Kunkel LM, Okamoto K： beta-Synemin localizes to regions of high stress in human skeletal myofibers. Muscle Nerve 30: 337-346, 2004
Shimatsu Y, Uchida M, Niki R, Imai H: Effects of a synthetic progestogen, altrenogest, on oestrus synchronisation and fertility in miniature pigs. Vet Rec 155: 633-635, 2004
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著 書
2011
鈴木友子，武田伸一：筋ジストロフィーモデルマウス．完全版マウス・ラット疾患モデル活用ハンドブック，株式会社羊土社，PP378-393，2011
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2010
Miyagoe-Suzuki Y, Takeda S: Mechanobiology in skeletal muscle: conversion of mechanical information into molecular signal. Mechanosensing Biology (ed.Masaki Noda), Springer Japan, pp1-219, 2010
Okada T, Takeda S: Advances in molecular therapy research on dystrophin-deficient muscular dystrophy. In, Gene Therapy and Regulation (ed. by Roger.Bertolotti), World Scientific, NJ. 2010, 5(1), pp113-123.
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2009
Ito N ＆ Miyagoe-Suzuki Y : Neuronal NOS as a regulator of muscle mass. Muscle Cell Physiology, pp97-107, 2009, Osaka University Press
鈴木友子，武田伸一：骨格筋. 炎症・再生医学事典，朝倉書店，pp453-456, 2009
中村昭則，武田伸一：ジストロフィン異常症．内科学症例図説，朝倉書店，pp 575-577, 2009
中村昭則，武田伸一：Duchenne型筋ジストロフィー. TOPICS 治療研究の現状，埜中征哉監修，小牧宏文編集，小児筋疾患診療ハンドブック，診断と治療社，pp93-98, 2009
青木吉嗣，武田伸一：筋ジストロフィー多発筋炎 研修医のための神経内科診療 新興医学出版社，pp248-252, 2010
Okada T, Takeda S: Gene therapy for Duchenne muscular dystrophy. in A Guide to Human Gene Therapy (ed. by Roland W. Herzog and Sergei Zolotukhin), World Scientific, NJ; in press
武田伸一: 筋ジストロフィー治療法研究の進歩. こころの健康科学研究の現状と課題 3.3: 315-327, 2007
武田伸一: ジストロフィン欠損における新たな分子病態. 小児神経学の進歩 第36集: 132-138, 2007
鈴木友子，武田伸一：筋ジストロフィーの治療を目指して，先進・脳神経科学，監修：高坂新一，編著：中村俊，培風館：174-187, 2006
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2008
Miyagoe-Suzuki Y, Uezumi A, Takeda S: Side Population (SP) cells and skeletal muscle differentiation. Recent advances of skeletal muscle differentiation, Research Signpost, 378/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India, 2008
中村昭則，武田伸一：筋ジストロフィーのexon skipping療法の試み．Annual Review 神経 中外医学社, pp 241-251, 2009
青木吉嗣，武田伸一：筋ジストロフィー．神経疾患最新の治療2009-2011, 南江堂, pp 309-311 2009-2011
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総 説
2011
鈴木友子，武田伸一：筋ジストロフィー．総合リハビリテーション，Vol.39，No.1，pp25-29, 2011
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2010
清水裕子，武田伸一：筋ジストロフィーの分子治療．―遺伝子診断の進歩とゲノム治療の展望―，遺伝子診療学（第2版）68巻 増刊号8（2010年8月20日発行），PP650-653，2010
青木吉嗣，武田伸一：デュシェンヌ型筋ジストロフィーのエクソン・スキッピング療法．神経難病の最新治療法［第１部］，難病と在宅ケア，Vol.16，No.6, PP6-9，2010
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2009
Ito N, Miyagoe-Suzuki Y: Neuronal NOS as a regulator of muscle mass. Editor: Yoshinobu Ohira. Muscle Cell Physiology, Research Signpost, Fort P.O., Trivandrum-695 023, Kerala, India, in press, 2009
矢田英理香，武田伸一：iPS細胞を用いた筋ジストロフィー治療の展望 難病と在宅ケア，Vol.15,No.1,24-27,2009
永田哲也，武田伸一：筋ジストロフィーとエクソン・スキッピング. 生物の科学遺伝，Vol.63, No.5, 84-89,2009
鈴木友子,武田伸一：筋ジストロフィーに対する先端治療法の開発ゲノム医学，Vol.9，No.3,195-198, 2009
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2008
Miyagoe-Suzuki Y, Uezumi A, Takeda S: Side population (SP) cells and skeletal muscle differentiation Recent Advances of Skeletal Muscle Differentiation Editors: Kunihiro Tsuchida and Shin’ichi Takeda. Research Signpost 378/661(2) Fort P.O., Trivandrum-695 023, Kerala, India, 2008
Okada T, Ozawa K: Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy. Front Biosci 13: 1887-1891, 2008.
Ozawa K., Sato K., Oh I, Ozaki K., Uchibori R, Obara Y, Kikuchi Y, Ito T, Okada T, Urabe M, Mizukami H, Kume A. Cell and gene therapy using mesenchymal stem cells (MSCs). J Autoimmun 30: 121-127, 2008
小林正典, 武田伸一: 筋ジストロフィーの遺伝子治療．総合リハビリテーション36: 1043-1049, 2008
齊藤崇, 武田伸一: 高齢者の筋ジストロフィー／多発性筋炎のケアModern Physician: 28, 656-660, 2008
笠原優子、岡田尚巳、武田伸一: ウイルスベクターを用いた筋ジストロフィーの治療法開発 医学のあゆみ 226: 379-383, 2008
武田伸一：デュシェンヌ型筋ジストロフィーの治療 財団法人 精神・神経科学振興財団 News Letter No.3,
2008
吉村まどか, 武田伸一: 筋ジストロフィー・ミオパチー 総合臨床 57: 606-608, 2008
深田宗一朗, 鈴木 友子, 武田 伸一: 筋ジストロフィーの治療とケア：筋衛星細胞の維持 活性化と自己複製の制御機構. 難病と在宅ケア 14: 50-52, 2008
岡田尚巳: 間葉系幹細胞を利用した癌遺伝子治療 最新医学63: 64-71, 2008
吉田幹晴: サルコグリカノパチー. Clinical Neuroscience（臨床神経科学）26: 152-153, 2008
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2007
Naoki Suzuki, Yuko Miyagoe-Suzuki, Shin’ichi Takeda. Gene Therapy for Duchenne Muscular Dystrophy Future Neurology, Vol. 2(1), 87-96, 2007
武田伸一: 国立精神・神経センターにおける筋ジストロフィー研究の成果. 週刊社会保障, No.2426: 31, 2007
Suzuki N, Miyagoe-Suzuk Y, Takeda S: Gene therapy for Duchenne muscular dystrophy. Future Neurology 2(1): 87-96, 2007
湯浅勝敏, 土方貴雄, 武田伸一: 筋ジストロフィーの遺伝子治療における骨格筋への遺伝子デリバリー. Drug Delivery System 22(2): 140-147, 2007
西山章代, 武田伸一: 骨格筋へのin vivo 遺伝子導入. バイオテクノロジージャーナル 7: 183-187, 2007
本橋紀夫, 武田伸一: 筋肉の再生. THE BONE 21(4): 61-64, 2007
辛鎮洪, 武田伸一: 筋ジストロフィーの治療戦略. BRAIN and NERVE 59(4): 415-424, 2007
吉田幹晴：ジストロフィン複合体におけるタンパク質間相互作用. 生体の科学 58(5): 440-441, 2007
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2006
松尾雅文、武田伸一 : 最近分かった筋ジストロフィーの病態と治療. 脳と発達 38(2) : 129-131, 2006
横田俊文、武田伸一 : 筋ジストロフィーに対する遺伝子治療の試み. 医学のあゆみ 216(10) : 743-747, 2006
上住聡芳，鈴木直輝，武田伸一： 筋疾患の病態と診断, 治療戦略の最前線, 筋ジストロフィーの再生医療, 小児科診療・第69巻・4号：570-574, 2006
西山章代，武田伸一： 筋ジストロフィーのモデル動物と遺伝子治療, Current Insights in Neurological Science VOL.14 No.1: 8-9, 2006
西山章代，武田伸一： 骨格筋組織への in vivo遺伝子導入, BIOバイオテクノロジージャーナル VOl.7 No.2, 3-4 : 183-187, 2006
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2005
大島幸子、武田伸一： 筋ジストロフィーの動物の心筋障害．神経内科 62(6)：539-546, 2005
吉村まどか、武田伸一： 筋ジストロフィーの遺伝子治療．BRAIN MEDICAL 17(3)：221-228, 2005
西山章代、武田伸一： 筋ジストロフィーのモデル動物と遺伝子治療．Neurological Science 14(1)：8-9, 2005
武田伸一、鈴木友子： 筋ジストロフィーの発症メカニズムと治療研究. -疾患解明Overview- 実験医学 23(10)：1590-1596, 2005
吉田幹晴： ジストログリカン複合体とサルコグリカン複合体(DAG1, SGC). 生体の科学 56(5)：486-487, 2005
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2004
武田伸一： 筋ジストロフィーモデル動物における遺伝子治療研究の現況と展望．第45回日本神経学会総会シンポジウム，遺伝性筋ジストロフィーの根本的治療をめざして．臨床神経，44: 911-913, 2004
島津美樹, 武田伸一： 筋ジストロフィーのモデル動物 ?｢進化｣する疾患モデル動物(第8回)?, 細胞工学，23: 1082-1085, 2004
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