National Center for Neurology and Phychiatry Department of Molecular Therapy, National Institute of Neuroscience

Publications

Original Articles

As of today, 2017.09.26

2017

  1. Takeuchi F, Komaki H, Yamagata Z, Maruo K, Rodger S, Kirschner J, Kubota T, Kimura E, Takeda S, Gramsch K, Vry J, Bushby K, Lochmüller H, Wada K, Nakamura H: A comparative study of care practices for young boys with Duchenne muscular dystrophy between Japan and European countries: implications of early diagnosis. Neuromuscul Disord. Neuromuscul Disord. 2017 Jul 6. pii: S0960-8966(17)30068-8. doi: 10.1016/j.nmd.2017.06.557. [Epub ahead of print] 
  2. Echigoya Y, Nakamura A, Nagata T, Urasawa N, Lim KR, Trieu N, Panesar D, Kuraoka M, Moulton HM, Saito T, Aoki Y, Iversen P, Sazani P, Kole R, Maruyama R, Partridge T, Takeda S, Yokota T: Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 114: 4213-4218, 2017
  3. Ito N, Kii I, Shimizu N, Tanaka H, Takeda S: Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells. Sci Rep. 7(1):8097, 2017
  4. Echigoya Y, Nakamura A, Nagata T, Urasawa N, Lim KR, Trieu N, Panesar D, Kuraoka M, Moulton HM, Saito T, Aoki Y, Iversen P, Sazani P, Kole R, Maruyama R, Partridge T, Takeda S, Yokota T: Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 114: 4213-4218, 2017
  5. Miyagoe-Suzuki Y, Nishiyama T, Nakamura M, Narita A, Takemura F, Masuda S, Minami N, Murayama K,  Komaki H, Goto Y, Takeda S: Induction of Pluripotent Stem Cells from a Manifesting Carrier of Duchenne Muscular Dystrophy and Characterization of Their X-Inactivation Status. Stem Cells Int. 7906843, 9 pages, 2017
  6. Aoki Y, Manzano R, Lee Y, Dafinca R, Aoki M, Douglas AG, Varela MA1 Sathyaprakash C, Scaber J, Barbagallo P, Vader P, Mäger I, Ezzat K, Turner MR, Ito N, Gasco S, Ohbayashi N, El Andaloussi S, Takeda S, Fukuda M, Talbot K, Wood MJ: C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia. Brain.2017 Apr 1;140(4):887-897.
  7. Hyzewicz J, Tanihata J, Kuraoka M, Nitahara-Kasahara Y, Beylier T, Ruegg UT, Vater A, Takeda S: Low-Intensity Training and the C5a Complement Antagonist NOX-D21 Rescue the mdx Phenotype through Modulation of Inflammation. Am J Pathol. 2017 Mar 15. pii: S0002-9440(17)30195-5. in press?
  8. Maruyama R, Echigoya Y, Caluseriu O, Aoki Y, Takeda S, Yokota T: Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy. Methods Mol Biol.1565: 201-213, 2017

2016

  1. Matsuzaka Y, Tanihata J, Komaki H, Ishiyama A, Oya Y, Rüegg U, Takeda SI, Hashido K: Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice. PLoS One. 11(12):e0167811
  2. Vila MC, Rayavarapu S, Hogarth MW, Van der Meulen JH, Horn A, Defour A, Takeda S, Brown KJ, Hathout Y, Nagaraju K, Jaiswal JK: Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy. Cell Death Differ. 2016 Nov 11. doi: 10.1038/cdd.2016.127.
  3. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T: Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Int J Mol Sci. 17: E1722, 2016
  4. Takeuchi F, Komaki H, Nakamura H, Yonemoto N, Kashiwabara K, Kimura E, Takeda S: Trends in steroid therapy for Duchenne muscular dystrophy in Japan. Muscle Nerve. 54: 673-680, 2016
  5. Harris E, Bladen CL, Mayhew A, James M, Bettinson K, Moore U, Smith FE, Rufibach L, Cnaan A, Bharucha-Goebel DX, Blamire AM, Bravver E, Carlier PG, Day JW, Díaz-Manera J, Eagle M, Grieben U, Harms M, Jones KJ, Lochmüller H, Mendell JR, Mori-Yoshimura M, Paradas C, Pegoraro E, Pestronk A, Salort-Campana E, Schreiber-Katz O, Semplicini C, Spuler S1, Stojkovic T, Straub V, Takeda S, Rocha CT, Walter MC, Bushby K ; Jain COS Consortium: The Clinical Outcome Study for dysferlinopathy: An international multicenter study. Neurol Genet. 2(4):e89, eCollection 2016
  6. Uezumi A, Nakatani M, Ikemoto-Uezumi M, Yamamoto N, Morita M, Yamaguchi A, Yamada H, Kasai T, Masuda S, Narita A, Miyagoe-Suzuki Y, Takeda S, Fukada S, Nishino I, Tsuchida K: Cell-Surface Protein Profiling Identifies Distinctive Markers of Progenitor Cells in Human Skeletal Muscle. Stem Cell Reports. 7: 263-278, 2016
  7. Nakamura A, Fueki N, Shiba N, Motoki H, Miyazaki D, Nishizawa H, Echigoya Y, Yokota T, Aoki Y, Takeda S:Deletion of exons 3-9 encompassing a mutational hot spot in the DMD gene presents an asymptomatic phenotype, indicating a target region for multiexon skipping therapy. J Hum Genet. 61: 663-667, 2016
  8. Shimizu R, Ogata K, Tamaura A, Kimura E, Ohata M, Takeshita E, Nakamura H, Takeda S, Komaki H: Clinical trial network for the promotion of clinical research for rare diseases in Japan: muscular dystrophy clinical trial network. BMC Health Serv Res.16:241, 2016
  9. Miskew Nichols B, Aoki Y, Kuraoka M, Lee JJ, Takeda S, Yokota T: Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy. J Vis Exp. 24: 111, 2016
  10. Ito N, Shimizu N, Tanaka H, Takeda S: Enhancement of satellite cell transplantation efficiency by leukemia inhibitory factor. J Neuromuscul Dis. 3: 201-207, 2016
  11. Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami K, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TA, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S: Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. Exp Anim. 65: 175-87, 2016
  12. Kimura K, Morita H, Daimon M, Horio M, Kawata T, Nakao T, Hirokawa M, Kitao R, Watanabe D, Komori T, Nagata T, Takeda S, Komaki H, Segawa K, Nakajima T, Takenaka K, Komuro I: Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy. Int Heart J. 57: 386-8, 2016
  13. Kuraoka M, Kimura E, Nagata T, Okada T, Aoki Y, Tachimori H, Yonemoto N, Imamura M, Takeda S: Serum Osteopontin as a Novel Biomarker for Muscle Regeneration in Duchenne Muscular Dystrophy. Am J Pathol. 186:1302-1312, 2016

2015

  1. Ezzat K, Aoki Y, Koo T, McClorey G, Benner L, Coenen-Stass A, O'Donovan L, Lehto T, Garcia-Guerra A, Nordin J, Saleh AF, Behlke M, Morris J, Goyenvalle A, Dugovic B, Leumann C, Gordon S, Gait MJ, El Andaloussi S, Wood MJ:Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides. Nano Lett. 15: 4364-4373, 2015
  2. Yamaguchi M, Watanabe Y, Ohtani T, Uezumi A, Mikami N, Nakamura M, Sato T, Ikawa M, Hoshino M, Tsuchida K, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H, Fukada S: Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche. Cell Rep. 13: 302-314, 2015
  3. Mizuno S, Yoda M, Shimoda M, Tohmonda T, Okada Y, Toyama Y, Takeda S, Nakamura M, Matsumoto M, Horiuchi K: A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool. J Biol Chem. 290: 28456-28464, 2015
  4. Imamura M, Nakamura A, Mannen H, Takeda S: Characterization of WWP1 protein expression in   skeletal muscle of muscular dystrophy chickens. J Biochem. 159: 171-179, 2015
  5. Domi T, Porrello E, Velardo D, Capotondo A, Biffi A, Tonlorenzi R, Amadio S, Ambrosi A,  Miyagoe-Suzuki Y, Takeda S, Ruegg MA, Previtali SC:Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A. Skelet    Muscle. 5: 30, 2015
  6. Kimura K, Morita H, Daimon M, Kawata T, Nakao T, Lee SL, Hirokawa M, Ebihara A, Nakajima T, Ozawa T, Yonemochi Y, Aida I, Motoyoshi Y, Mikata T, Uchida I, Komori T, Kitao R, Nagata T, Takeda S, Komaki H, Segawa K, Takenaka K, Komuro I:Prognostic impact of venous thromboembolism in patients with Duchenne muscular dystrophy: Prospective multicenter 5-year cohort study. Int J Cardiol. 191: 178-180, 2015
  7. Ishii K, Suzuki N, Mabuchi Y, Ito N, Kikura N, Fukada SI, Okano H, Takeda S, Akazawa C: Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation During Muscle Regeneration. Stem Cells. 33: 3017-3027, 2015
  8. Shiba N, Miyazaki D, Yoshizawa T, Fukushima K, Shiba Y, Inaba Y, Imamura M, Takeda S, Koike K, Nakamura A: Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy. Biochim Biophys Acta. 1852: 2170-2182, 2015
  9. Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schütz G, Takeda S, Tanaka H: A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodeling. Nat Commun. 6: 6693, 2015
  10. Hayashiji N, Yuasa S, Miyagoe-Suzuki Y, Hara M, Ito N, Hashimoto H, Kusumoto D, Seki T, Tohyama S, Kodaira M, Kunitomi A, Kashimura S, Takei M, Saito Y, Okata S, Egashira T, Endo J, Sasaoka T, Takeda S, Fukuda K: G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy. Nat Commun. 6: 6745, 2015

2014

  1. Yokota T, Miyagoe-Suzuki Y, Ikemoto T, Matsuda R, Takeda S: α1-Syntrophin deficient mice exhibit impaired muscle force recovery after osmotic shock. Muscle Nerve 49: 728-735, 2014
  2. Nitahara-Kasahara Y, Hayashita-Kinoh H, Chiyo T, Nishiyama A, Okada H, Takeda S, Okada T: Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10. Hum Mol Genet 23: 3990-4000, 2014
  3. Hathout Y, Marathi RL, Rayavarapu S, Zhang A, Brown KJ, Seol H, Gordish-Dressman H, Cirak S, Bello L, Nagaraju K, Partridge T, Hoffman EP, Takeda S, Mah JK, Henricson E, McDonald C: Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients. Hum Mol Genet 23: 6458-6469, 2014
  4. Matsuzaka Y, Kishi S, Aoki Y, Komaki H, Oya Y, Takeda S, Hashido K: Three novel serum biomarkers, miR-1, miR-133a, and miR-206 for Limb-girdle muscular dystrophy, Facioscapulohumeral muscular dystrophy, and Becker muscular dystrophy. Environ Health Prev Med 19: 452-458, 2014
  5. Arimura S, Okada T, Tezuka T, Chiyo T, Kasahara Y, Yoshimura T, Motomura M, Yoshida N, Beeson D, Takeda S, Yamanashi Y: Neuromuscular disease. DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction. Science 345: 1505-1508, 2014
  6. Mori-Yoshimura M, Hayashi YK, Yonemoto N, Nakamura H, Murata M, Takeda S, Nishino I, Kimura E: Nationwide patient registry for GNE myopathy in Japan. Orphanet J Rare Dis 9: 150, 2014
  7. Ogawa R, Ma Y, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S: Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration. Development 142: 51-61, 2015
  8. Hayashita-Kinoh H, Yugeta N, Okada H, Nitahara-Kasahara Y, Chiyo T, Okada T, Takeda S: Intra-amniotic rAAV-mediated microdystrophin gene transfer improves canine X-linked muscular dystrophy and may induce immune tolerance. Mol Ther 23: 627-637, 2015
  9. Hyzewicz J, Tanihata J, Kuraoka M, Ito N, Miyagoe-Suzuki Y, Takeda S: Low intensity training of mdx mice reduces carbonylation and increases expression levels of proteins involved in energy metabolism and muscle contraction. Free Radic Biol Med 82: 122-136, 2015
  10. Ohtsuka Y, Kanagawa M, Yu CC, Ito C, Chiyo T, Kobayashi K, Okada T, Takeda S, Toda T: Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression. Sci Rep 5: 8316, 2015
  11. Echigoya Y, Aoki Y, Miskew B, Panesar D, Touznik A, Nagata T, Tanihata J, Nakamura A, Nagaraju K, Yokota T: Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice. Mol Ther Nucleic Acids 4 :e225, 2015
  12. Nakamura K, Fujii W, Tsuboi M, Tanihata J, Teramoto N, Takeuchi S, Naito K, Yamanouchi K, Nishihara M: Generation of muscular dystrophy model rats with a CRISPR/Cas system. Sci Rep 4: 5635, 2014

2013

  1. Kimura K, Takenaka K, Ebihara A, Uno K, Morita H, Nakajima T, Ozawa T, Aida I, Yonemochi Y, Higuchi S, Motoyoshi Y, Mikata T, Uchida I, Ishihara T, Komori T, Kitao R, Nagata T, Takeda S, Yatomi Y, Nagai R, Komuro I: Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy - Prospective multicenter cohort study. Int J Cardiol 168: 1900-1904, 2013
  2. Rayavarapu S, Coley W, Cakir E, Jahnke V, Takeda S, Aoki Y, Grodish-Dressman H, Jaiswal JK, Hoffman EP, Brown KJ, Hathout Y, Nagaraju K: Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse. Mol Cell Proteomics 12: 1061-1073, 2013
  3. Ito N, Ruegg UT, Kudo A, Miyagoe-Suzuki Y, Takeda S: Capsaicin mimics mechanical load-induced intracellular signaling events: Involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy. Channels (Austin) 7: 221-224, 2013
  4. Kanagawa M, Yu CC, Ito C, Fukada SI, Hozoji-Inada M, Chiyo T, Kuga A, Matsuo M, Sato K, Yamaguchi M, Ito T, Ohtsuka Y, Katanosaka Y, Miyagoe-Suzuki Y, Naruse K, Kobayashi K, Okada T, Takeda S, Toda T: Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression.Hum Mol Genet 22: 3003-3015, 2013
  5. Oana K, Oma Y, Suo S, Takahashi MP, Nishino I, Takeda S, Ishiura S: Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice. Sci Rep 3:2142, 2013
  6. Okada H, Ishibashi H, Hayashita-Kinoh H, Chiyo T, Nitahara-kasahara Y, Baba Y, Watanabe S, Takeda S, Okada T: Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With rAAV1 and rAAV9. Mol Ther Nucleic Acids. 2: e95 2013
  7. Nakamura A, Kobayashi M, Kuraoka M, Yuasa K, Yugeta N, Okada T, Takeda S: Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog. Sci Rep 3:2183, 2013
  8. Aoki Y, Nagata T, Yokota T, Nakamura A, Wood MJ, Partridge T, Takeda S: Highly efficient in vivo delivery of PMO into regenerating myotubes and rescue in laminin-α2 chain-null congenital muscular dystrophy mice. Hum Mol Genet. 22: 4914-4928, 2013
  9. Takeuchi F, Yonemoto N, Nakamura H, Shimizu R, Komaki H, Mori-Yoshimura M, Hayashi YK, Nishino I, Kawai M, Kimura E, Takeda S. Prednisolone improves walking in Japanese Duchenne muscular dystrophy patients. J Neurol 260: 3023-3029, 2013
  10. Ishibashi H, Motohashi H, Kumon M, Yamamoto K, Okada H, Okada T, Seki K: Ultrasound-guided non-surgical embryo collection in the common marmoset. Reproductive Biology 13: 139-144, 2013
  11. Ishibashi H, Motohashi H, Kumon M, Yamamoto K, Okada H, Okada T, Seki K: Efficient embryo transfer in the common marmoset monkey (Callithrix jacchus) with a reduced transfer volume: a non-surgical approach with cryo-preserved late-stage embryos. Biol Reprod 88: 115, 2013
  12. Echigoya Y, Lee J, Rodrigues M, Nagata T, Tanihata J, Nozohourmehrabad A, Panesar D, Miskew B, Aoki Y, Yokota T: Mutation types and aging differently affect revertant fiber expansion in dystrophic mdx and mdx52 mice. PLoS One 8: e69194, 2013
  13. Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S : Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS. Neuron 81:1001-1008, 2014

2012

  1. Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K: Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junction. Mol Ther 20(7): 1384-1392, 2012
  2. Aoki Y, Yokota T, Nagata T, Nakamura A, Tanihata J, Saito T, Duguez SMR, Nagaraju K, Hoffman EP, Partridge T, Takeda S: Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery. Proc Natl Acad Sci USA 109(34): 13763-13768, 2012
  3. Yuasa K, Takeda S, Hijikata T: A conserved regulatory element located far downstream of the gls locus modulates gls expression through chromatin loop formation during myogenesis. FEBS Lett 586(19): 3464-3470, 2012
  4. Yamaguchi M, Ogawa R, Watanabe Y, Uezumi A, Miyagoe-Suzuki Y, Tsujikawa K, Yamamoto H, Takeda S, Fukada S: Calcitonin receptor and Odz4 are differently expressed in Pax7-positive cells during skeletal muscle regeneration. J Mol Histol 43(5): 581-587, 2012
  5. Yokota T, Nakamura A, Nagata T, Saito T, Kobayashi M, Aoki Y, Echigoya Y, Partridge T, Hoffman EP, Takeda S: Extensive and prolonged restoration of dystrophin expression with vivo-morpholino-mediated multiple exon skipping in dystrophic dogs. Nucleic Acid Ther 22(5): 306-315, 2012
  6. Relucio J, Menezes MJ, Miyagoe-Suzuki Y, Takeda S, Colognato H: Laminin regulates postnatal oligodendrocyte production by promoting oligodendrocyte progenitor survival in the subventricular zone. Glia 60(10): 1451-1467, 2012
  7. Ito N, Ruegg UT, Kudo A, Miyagoe-Suzuki Y, Takeda S: Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy. Nat Med. 19(1): 101-106, 2013
  8. Baba Y, Satoh S, Otsu M, Sasaki E, Okada T, Watanabe S: In vitro cell subtype-specific transduction of adeno-associated virus in mouse and marmoset retinal explants culture.Biochimie 94(12): 2716-2722, 2012
  9. Tremblay JP, Xiao X, Aartsma-Rus A, Barbas C, Blau HM, Bogdanove AJ, Boycott K, Braun S, Breakefield XO, Bueren JA, Buschmann M, Byrne BJ, Calos M, Cathomen T, Chamberlain J, Chuah M, Cornetta K, Davies KE, Dickson JG, Duchateau P, Flotte TR, Gaudet D, Gersbach CA, Gilbert R, Glorioso J, Herzog RW, High KA, Huang W, Huard J, Joung JK, Liu D, Liu D, Lochmüller H, Lustig L, Martens J, Massie B, Mavilio F, Mendell JR, Nathwani A, Ponder K, Porteus M, Puymirat J, Samulski J, Takeda S, Thrasher A, Vandendriessche T, Wei Y, Wilson JM, Wilton SD, Wolfe JH, Gao G: Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases. Mol Ther 21(2): 266-268, 2013
  10. Ito T, Ogawa R, Uezumi A, Ohtani T, Watanabe Y, Tsujikawa K, Miyagoe-Suzuki Y, Takeda S, Yamamoto H, Fukada SI: Imatinib attenuates dystrophic condition in severe mouse dystrophy and inhibits both proliferation and fibrosis-marker expression in muscle mesenchymal progenitors. Neuromuscul Disord 23(4): 349-356, 2013

2011

  1. Miyazaki D, Nakamura A, Fukushima K, Yoshida K, Takeda S, Ikeda S:Matrix metalloproteinase-2 ablation in dystrophin-deficient mdx muscles reduces angiogenesis resulting in impaired growth of regenerated muscle fibers. Hum Mol Genet. 20: 1787-1799, 2011
  2. Mizuno H, Nakamura A, Aoki Y, Ito N, Kishi S, Yamamoto K, Sekiguchi M, Takeda S, Hashido K:Identification of Muscle-Specific MicroRNAs in Serum of Muscular Dystrophy Animal Models: Promising Novel Blood-Based Markers for Muscular Dystrophy. PLoS One. 30; 6(3):e18388, 2011
  3. Takahashi H, Kanesaki H, Igarashi T, Kameya S, Yamaki K, Mizota A, Kudo A, Miyagoe-Suzuki Y, Takeda S, Takahashi H: Reactive gliosis of astrocytes and Müller glial cells in retina of POMGnT1-deficient mice. Mol Cell Neurosci. 47: 119-130, 2011
  4. Pichavant C, Aartsma-Rus A, Clemens PR, Davies KE, Dickson G, Takeda S, Wilton SD, Wolff JA, Wooddell CI, Xiao X, Tremblay JP: Current status of pharmaceutical and genetic therapeutic approaches to treat DMD. Mol Ther. 19: 830-840, 2011
  5. Yamada T, Okaniwa N, Saneyoshi H, Ohkubo A, Seio K, Nagata T, Aoki Y, Takeda S, Sekine M: Synthesis of 2'-O-[2-(N-Methylcarbamoyl)ethyl]ribonucleosides using Oxa-Michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ribonucleosides. J Org Chem. 76: 3042-3053, 2011
  6. Takano H, Fujii Y, Yugeta N, Takeda S, Wakao Y: Assessment of Left Ventricular Regional Function in Affected and Carrier Dogs with Duchenne Muscular Dystrophy Using Speckle Tracking Echocardiography. BMC Cardiovasc Disord. 11: 23 doi:10.1186/1471-2261-11-23, 2011
  7. Hoffman EP, Bronson A, Levin AA, Takeda S, Yokota T, Baudy AR, Connor EM: Restoring dystrophin expression in duchenne muscular dystrophy muscle progress in exon skipping and stop codon read through. Am J Pathol. 179: 12-22, 2011
  8. Masamizu Y, Okada T, Kawasaki K, Ishibashi H, Yuasa S, Takeda S, Hasegawa I, Nakahara K: Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9. Neuroscience. 193: 249-258, 2011
  9. Shin JH, Nitahara-Kasahara Y, Hayashita-Kinoh H, Ohshima-Hosoyama S, Kinoshita K, Chiyo T, Okada H, Okada T, Takeda S: Improvement of cardiac fibrosis in dystrophic mice by rAAV9-mediated microdystrophin transduction. Gene Ther. 18: 910-919, 2011
  10. Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M: MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss. J Cell Biochem. 112: 3525-3530, 2011
  11. Taniguchi-Ikeda M, Kobayashi K, Kanagawa M, Yu CC, Mori K, Oda T, Kuga A, Kurahashi H, Akman HO, DiMauro S, Kaji R, Yokota T, Takeda S, Toda T : Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy. Nature. 478: 127-131, 2011
  12. Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H: Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers. Development. 138: 4609-4619, 2011
  13. Wang B, Miyagoe-Suzuki Y, Yada E, Ito N, Nishiyama T, Nakamura M, Ono Y, Motohashi N, Segawa M, Masuda S, Takeda S: Reprogramming efficiency and quality of induced Pluripotent Stem Cells (iPSCs) generated from muscle-derived fibroblasts of mdx mice at different ages. PLoS Curr. 10.1371/currents.RRN1274, 2011
  14. Uezumi A, Ito T, Morikawa D, Shimizu N, Yoneda T, Segawa M, Yamaguchi M, Ogawa R, Matev MM, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Tsuchida K, Yamamoto H, Fukada S: Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle. J Cell Sci, 124: 3654-3664, 2011
  15. Koo T, Okada T, Athanasopoulos T, Foster H, Takeda S, Dickson G: Long-term functional adeno-associated virus-microdystrophin expression in the dystrophic CXMDj dog. J Gene Med. 13: 497-506, 2011
  16. Nitahara-Kasahara Y, Hayashita-Kinoh H, Ohshima-Hosoyama S, Okada H, Wada-Maeda M, Nakamura A, Okada T, Takeda S: Long-term engraftment of multipotent mesenchymal stromal cells that differentiate to form myogenic cells in dogs with Duchenne muscular dystrophy. Mol Ther. 20: 168-177, 2012

2010

  1. Fukada S, Morikawa D, Yamamoto Y, Yoshida T, Sumie N, Yamaguchi M, Ito T, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H:Genetic background affects properties of satellite cells and mdx phenotypes. Am J Pathol. 176: 2414-2424, 2010
  2. Yajima H, Motohashi N, Ono Y, Sato S, Ikeda K, Masuda S, Yada E, Kanesaki H, Miyagoe-Suzuki Y, Takeda S, Kawakami K: Six family genes control the proliferation and differentiation of muscle satellite cells. Exp Cell Res. 316: 2932-2944, 2010
  3. Masamizu Y, Okada T, Ishibashi H, Takeda S, Yuasa S, Nakahara K: Efficient gene transfer into neurons in monkey brain by adeno-associated virus 8. Neuroreport. 21:447-451, 2010
  4. Saito T, Nakamura A, Aoki Y, Yokota T, Okada T, Osawa M, Takeda S: Antisense PMO Found in Dystrophic Dog Model Was Effective in Cells from Exon 7-Deleted DMD Patient. PLoS One. 5(8). pii: e12239, 2010
  5. Sugita H, Takeda S: Progress in muscular dystrophy research with special emphasis on gene therapy. Proc Jpn Acad Ser B Phys Biol Sci. 86:748-56, 2010
  6. Suzuki N, Mizuno H, Warita H, Takeda S, Itoyama Y, Aoki M:Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis. J Neurol Sci. 294: 95-101, 2010
  7. Kanagawa M, Omori Y , Sato S, Kobayashi K, Miyagoe-Suzuki Y, Takeda S, Endo T, Furukawa T, Toda T : Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. J Biol Chem. 285:31208-31216, 2010
  8. Aoki Y, Nakamura A, Yokota T, Saito T, Okazawa H, Nagata T, Takeda S:In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse. Mol Ther. 18, 1995-2005, 2010
  9. Miyagoe-Suzuki Y, Takeda S: Gene therapy for muscle disease. Exp Cell Res. 316: 3087-3092, 2010
  10. Yokota T, Hoffman E, Takeda S:Antisense oligo-mediated multiple exon skipping in a dog model of duchenne muscular dystrophy. Methods Mol Biol. 709:299-312, 2011
  11. Lu QL, Yokota T, Takeda S, Garcia L, Muntoni F, Partridge T:The status of exon skipping as a therapeutic approach to duchenne muscular dystrophy. Mol Ther. 19:9-15, 2011
  12. Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H:Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle. Cell Metab. 13:170-182, 2011
  13. Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H: SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses. J Neurochem. 116:1122-1137, 2011
  14. Nakamura A, Takeda S:Mammalian models of duchenne muscular dystrophy: pathological characteristics and therapeutic applications. J Biomed Biotechnol. doi: 10.1155/2011:184393.

2009

  1. Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada S, Yamamoto H, Motohashi N, Miyagoe-Suzuki Y, Takeda S, Heike T, Nakahata T : Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells. FASEB J 23: 1907-1919, 2009
  2. Yokota T, Lu QL, Partridge T, Kobayashi M, Nakamura A, Takeda S, Hoffman E:Efficacy of systemic morpholino exon-skipping in duchenne dystrophy dogs. Ann Neurol 65: 667-676, 2009
  3. Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N,Mills EM, Takeda S, Nikawa T : Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading. Mol Cell Biol 29: 4798-4811, 2009
  4. Nakamura A, Takeda S : Exon-skipping therapy for Duchenne muscular dystrophy, Neuropathology 29: 494-501, 2009
  5. Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa : A, Sakamoto K, Yamaguchi A: CCN3 and bone marrow cells. J Cell Commun Signal 3: 135-145, 2009
  6. Okada T, Nonaka-Sarukawa M, Uchibori R, Kinoshita K, Hayashita-Kinoh H, Nitahara-Kasahara Y, Takeda S, Ozawa K: Scalable purification of AAV1 and AAV8 vectors using dual ion-exchange adsorptive membranes. Hum Gene Ther 20: 1013-1021, 2009
  7. Guo P, Cui R, Chang YZ, Wu WS, Qian ZM, Yoshida K, Qiao YT, Takeda S, Duan XL:Hepcidin, an antimicrobial peptide is downregulated in ceruloplasmin-deficient mice. Peptides 30: 262-266, 2009
  8. Cui R, Duan XL, Anderson GJ, Qiao YT, Yu P, Qian ZM, Yoshida K, Takeda S, Guo P, Yang ZL,Chang YZ:Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice. J Trace Elem Med Biol 23: 290-299, 2009
  9. Kobayashi M, Nakamura A, Hasegawa D, Fujita M, Orima H, Takeda S: Evaluation of dystrophic dog pathology by fat-suppressed T2-weighted imaging. Muscle Nerve 40: 815-826, 2009
  10. Matsumoto H, Maruse H, Sasazaki S, Fujiwara A, Takeda S, Ichihara N, Kikuchi T, Mukai F, Mannen H: Expression pattern of WWP1 in muscular dystrophic and normal chickens, J. Poult. Sci 46: 95-99, 2009
  11. Uezumi A, Fukuda S, Yamamoto N, Takeda S, Tsuchida K: Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol 12: 143-152, 2010
  12. Masuda-Hirata M, Suzuki A, Amano Y, Yamashita K, Ide M, Yamanaka T, Sakai M, Imamura M, Ohno S. Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex. Genes Cells 14: 835-850, 2009
  13. Uchibori R, Okada T, Ito T, Urabe M, Mizukami H, Kume A, Ozawa K : Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy. J Gene Med 11: 373-381, 2009
  14. Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S. Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radic Biol Med 47:1049-1056, 2009

2008

  1. Tanihata J, Suzuki N, Miyagoe-Suzuki Y, Imaizumi K, Takeda S: Dowmstream utrophin enhancer is required for expression of utrophin in skeletal muscle. J Gene Med. 10: 702-713, 2008
  2. Urasawa N, Wada MR, Machida N, Yuasa K, Shimatsu Y, Wakao Y, Yuasa S, Sano T, Nonaka I, Nakamura A, Takeda S: Selective vacuolar degeneration in dystrophin deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. Circulation. 117: 2437-2448, 2008
  3. Matsumoto H, Maruse H, Inaba Y, Yoshizawa K, Sasazaki S, Fujiwara A, Nishibori M, Nakamura A, Takeda S, Ichihara N, Kikuchi T, Mukai F, Mannen H: The ubiquitin ligase gene (WWP1) is responsible for the chicken muscular dystrophy. FEBS Lett. 582: 2212-2218, 2008
  4. Hijikata T, Nakamura A, Isokawa K, Imamura M, Yuasa K, Ishikawa R, Kohama K, Takeda S, Yorifuji H: Plectin 1 links intermediate filaments to costameric sarcolemma through {beta}-synemin, {alpha}-dystrobrevin and actin. J Cell Sci. 121: 2062-2074, 2008
  5. Nakamura A, Yoshida K, Fukushima K, Ueda H, Urasawa N, Koyama J, Yazaki Y, Yazaki M, Sakai T, Haruta S, Takeda S, Ikeda S: Follow-up of three patients with a large in-frame deletion of exons 45-55 in the Duchenne muscular dystrophy (DMD) gene. J Clin Neurosci. 15: 757-763, 2008
  6. Nishiyama A, Ampong BN, Ohshima S, Shin JH, Nakai H, Imamura M, Miyagoe-Suzuki Y, Okada T, Takeda S: Recombinant adeno-associated virus type 8-mediated extensive therapeutic gene delivery into skeletal muscle of alpha-sarcoglycan-deficient mice. Hum Gene Ther. 19: 719-730, 2008
  7. Sato K, Yokota T, Ichioka S, Shibata M, Takeda S: Vasodilation of intramuscular arterioles under shear stress in dystrophin-deficient skeletal muscle is impaired through decreased nNOS expression. Acta Myol. 27:30-36, 2008
  8. Motohashi N, Uezumi A, Yada E, Fukada S, Fukushima K, Imaizumi K, Miyagoe-Suzuki Y, Takeda S: Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts. Am J Pathol. 173: 781-791, 2008
  9. Katsumata O, Honma T, Sanda M, Kamata A, Takeda S, Kondo H, Sakagami H: Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes. Brain Res. 1234:44-49, 2008
  10. Yuasa K, Hagiwara Y, Ando M, Nakamura A, Takeda S, Hijikata T: MicroRNA-206 is highly expressed in newly formed muscle fibers: implications regarding potential for muscle regeneration and maturation in muscular dystrophy. Cell Struct Funct. 33: 163-169, 2008
  11. Segawa M, Fukada S, Yamamoto Y, Yahagi H, Kanematsu M, Sato M, Ito T, Uezumi A, Hayashi S, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H: Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis. Exp Cell Res. 314: 3232-3244, 2008
  12. Ohshima S, Shin JH, Yuasa K, Nishiyama A, Kira J, Okada T, Takeda S: Transduction efficiency and immune response associated with the administration of AAV8 vector into dog skeletal muscle. Mol Ther. 17: 73-80, 2009
  13. Sekiguchi M, Zushida K, Yoshida M, Maekawa M, Kamichi S, Yoshida M, Sahara Y, Yuasa S, Takeda S, Wada K: A deficit of brain dystrophin impairs specific amygdala GABAergic transmission and enhances defensive behaviour in mice. Brain. 132: 124-135, 2009
  14. Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T: Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy. Hum Mol Genet. 18: 621-31, 2009
  15. Miyagoe-Suzuki Y, Masubuchi N, Miyamoto K, Wada MR, Yuasa S, Saito F, Matsumura K, Kanesaki H, Kudo A, Manya H, Endo T, Takeda S: Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro. Mech Dev. 126: 107-116, 2009
  16. Miyazaki D, Yoshida K, Fukushima K, Nakamura A, Suzuki K, Sato T, Takeda S, Ikeda S: Characterization of deletion breakpoints in patients with dystrophinopathy carrying a deletion of exons 45-55 of the Duchenne muscular dystrophy (DMD) gene. J Hum Genet. 54: 127-130, 2009
  17. Yokota T, Takeda S, Lu QL, Partridge TA, Nakamura A, Hoffman EP: A renaissance for antisense oligonucleotide drugs in neurology: exon skipping breaks new ground. Arch Neurol 66: 32-38, 2009
  18. Nonaka-Sarukawa M, Okada T, Ito T, Yamamoto K, Yoshioka T, Nomoto T, Hojo Y, Shimpo M, Urabe M, Mizukami H, Kume A, Ikeda U, Shimada K, Ozawa K: Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats. J Gene Med. 10: 368-374, 2008
  19. Liu Y, Okada T, Shimazaki K, Sheykholeslami K, Nomoto T, Muramatsu S, Mizukami H, Kume A, Xiao S, Ichimura K, Ozawa K: Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea. Mol Ther. 16: 474-480, 2008
  20. Nomoto T, Okada T, Shimazaki K, Yoshioka T, Nonaka-Sarukawa M, Ito T, Takeuchi K, Katsura KI, Mizukami H, Kume A, Ookawara S, Ikeda U, Katayama Y, Ozawa K: Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat. Gene Ther. 16: 383-391, 2009

2007

  1. Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, Takahashi T, Goto M, Mikami Y, Yasuda N, Akazawa H, Uezumi A, Takeda S, Komuro I: Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol. Jan 29;176(3): 329-41, 2007
  2. Fukushima K, Nakamura A, Ueda H, Yuasa K, Yoshida K, Takeda S, Ikeda SI: Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ). BMC Musculoskelet Disord Jun 28;8: 54, 2007
  3. Suzuki N, Motohashi N, Uezumi A, Fukada SI, Yoshimura T, Itoyama Y, Aoki M, Miyagoe-Suzuki Y, Takeda S: NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS. J Clin Invest. Sep;117(9): 2468-76, 2007
  4. Yuasa K, Yoshimura M, Urasawa N, Ohshima S, Howell JM, Nakamura A, Hijikata T, Miyagoe-Suzuki Y,. Takeda S: Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products.Gene Ther. Sep;14(17): 1249-60, 2007
  5. Fukada S, Uezumi A, Ikemoto M, Masuda S, Segawa M, Tanimura N, Yamamoto H, Miyagoe-Suzuki Y, Takeda S: Molecular signature of quiescent satellite cells in adult skeletal muscle. Stem Cells Oct;25(10): 2448-59, 2007
  6. Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Harada N, Hosaka T, Nakaya Y, Ishidoh K, Obata T, Ebina Y, Gu H, Takeda S, Kishi K, Nikawa T: Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes. Oct;56(10): 2511-22, 2007
  7. Ikemoto M, Fukada S, Uezumi A, Masuda S, Miyoshi H, Yamamoto H, Wada MR, Masubuchi N, Miyagoe-Suzuki Y, Takeda S: Autologous transplantation of SM/C-2.6(+) satellite cells transduced with micro-dystrophin CS1 cDNA by lentiviral vector into mdx mice. Mol Ther. Dec;15(12): 2178-85, 2007
  8. Fukada S, Yamamoto Y, Segawa M, Sakamoto K, Nakajima M, Sato M, Morikawa D, Uezumi A, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H: CD90-positive cells, an additional cell population, produce laminin <alpha>2 upon transplantation to dy3k/dy3k mice. Exp Cell Res. Jan 1;314(1): 193-203, 2008
  9. Yuasa K, Nakamura A, Hijikata T, Takeda S: Dystrophin deficiency in canine X-linked muscular dystrophy in Japan (CXMDJ) alters myosin heavy chain expression profiles in the diaphragm more markedly than in the tibialis cranialis muscle. BMC Musculoskelet Disord. Jan 9;9: 1, 2008
  10. Nakatani M, Takehara Y, Sugino H, Matsumoto M, Hashimoto O, Hasegawa Y, Murakami T, Uezumi A, Takeda S, Noji S, Sunada Y, Tsuchida K: Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice. FASEB J. Feb;22(2): 477-87, 2008
  11. Ideno J, Mizukami H, Kakehashi A, Saito Y, Okada T, Urabe M, Kume A, Kuroki M, Kawakami M, Ishibashi S, Ozawa K: Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model. Int J Mol Med Jan;19 (1): 75-79, 2007
  12. Takei Y, Mizukami H, Saga Y, Yoshimura I, Hasumi Y, Takayama T, Kohno T, Matsushita T, Okada T, Kume A, Suzuki M, Ozawa K: Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector. Int J Cancer Jan 15;120(2): 278-84, 2007
  13. Nakata M, Okada T, Ozawa K, Yada T: Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochem Biophys Res Commun Feb 23;353(4): 1046-51, 2007
  14. Liu Y, Okada T, Nomoto T, Ke X, Kume A, Ozawa K, Xiao S: Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo. Exp Mol Med Apr 30;39(2): 170-75, 2007
  15. Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K:Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats. Circ Res Sep 28; 101(7): 734-41,2007
  16. Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Sakata Y, Shimada K, Ozawa K: Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. Hypertension Sep;50(3): 531-36, 2007

2006

  1. Uezumi A, Ojima K, Ikemoto M, Masuda S, Miyagoe-Suzuki Y, Takeda S : Functional heterogeneity of side population cells in skeletal muscle Biochem Biophys Res Commun, 341:864-73, 2006
  2. Suzue N, Nikawa T, Onishi Y, Yamada C, Hirasaka K, Ogawa T, Furochi H, Kosaka H, Ishidoh K,Gu H, Takeda S, Ishimaru N, Hayashi Y, Yamamoto H, Kishi K, Yasui N:Ubiquitin ligase Cbl-b down-regulate bone formation through suppression of OGF-1 signaling in osteblasts during denervation. J Bone Miner Res. 2006 May; 21(5):722-34.
  3. Yokota T, Lu QL, Morgan JE, Davies KE, Fisher R, Takeda S, Partridge TA: Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration. J Cell Sci. 2006 Jul 1; 119(Pt 13): 2679-87.
  4. Shiga K, Yoshioka H, Matsumiya T, Kimura I, Takeda S, Imamura M:zeta-Sarcoglycan is a functional homologue of gamma-sarcoglycan in the formation of the sarcoglycan complex. Exp Cell Res. 2006 Jul 1;312(11):2083-92. Epub 2006 Apr 25.
  5. Pramono ZA, Lai PS, Tan CL, Takeda S, Yee WC:Identification and characterization of a novel human dysferlin transcript: dysferlin_v1.Hum Genet. 2006 Oct;120(3):410-9.
  6. Yugeta N, Urasawa N, Fujii Y, Yoshimura M, Yuasa K, Nakamura A, Wada M, Nakura M, Shimatsu Y, Tomohiro M, Takahashi A, Machida N, Wakao Y, Takeda S: Cardiac involvement in Beagle-based canine X-linked muscular dystrophy in Japan (CXMDJ): electrocardiographic, echocardiographic, and morphologic studies BMC Cardiovasc Disord. 2006 Dec 4;6:47.
  7. Suzuki N, Miyagoe-Suzuki Y, Takeda S: Gene Therapy for Duchenne Muscular Dystrophy Future Neurology, Jan 2007, Vol.2(1), 87-96.
  8. Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, Takahashi T, Goto M, Mikami Y, Yasuda N, Akazawa H, Uezumi A, Takeda S, Komuro I: Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol. 2007 Jan 29;176(3):329-41.
  9. Hagiwara Y, Fujita M, Imamura M, Noguchi S, Sasaoka T: Caveolin-3 deficiency decreases the gene expression level of osteopontin in mdx mouse skeletal muscle. Acta Myol. 25, 53-61, 2006

Book Chapter

As of today, 2016.12.15

2016

  1. Takeda S, Nagata T: Translational Research on DMD in Japan. Translational Research in Muscular Dystrophy, Springer, Tokyo, pp189-199, 2016
  2. Miyagoe-Suzuki Y, Takeda S: Stem Cell-Based Therapy for Duchenne Muscular Dystrophy. Translational Research in Muscular Dystrophy, Translational Research in Muscular Dystrophy, Springer, Tokyo, pp123-135, 2016

2013

  1. Okada T: Efficient AAV vector production system: Towards gene therapy for Duchenne muscular dystrophy. In Gene Therapy - Tools and Potential Applications (ed. by Francisco Martin), InTech, pp429-440, 2013

2012

  1. Miyagoe-Suzuki Y, Fukada S, Takeda S: Muscle Satellite Cells and Duchenne Muscular Dystrophy. Muscular dystrophy, InTech-Open Access Company, Croatia, pp333-348, 2012
  2. Okada T: Efficient AAV vector production system: Towards gene therapy for Duchenne muscular dystrophy. In Gene Therapy - Tools and Potential Applications (ed. by Francisco Martin), InTech, Croatia, pp429-449, 2012

2011

  1. Okada T, Takeda S: Progress and Challenges in AAV-Mediated Gene Therapy for Duchenne Muscular Dystrophy. Viral Gene Therapy (ed. by Ke Xu), InTech, Croatia, pp225-240, 2011
  2. Nagata T, Takeda S: The frontier of antisense oligonucleotide induced therapy (ed. by Takeda S). Fifty years of neuromuscular disorder research after discovery of creatine kinase as a diagnostic marker of muscular dystrophy, IGAKU-SHOIN Ltd., Japan, pp56-67, 2011
  3. Yokota T, Takeda S: Antisense oligo-mediated multiple skipping in a dog model of duchenne muscular dystrophy (ed. by Duan D). Muscle gene therapy, Methods and Protocols, Methods in Molecular Biology, Springer Science+Business Media, USA, pp299-312, 2011

2010

  1. Miyagoe-Suzuki Y, Takeda S: Mechanobiology in skeletal muscle: conversion of mechanical information into molecular signal. Mechanosensing Biology (ed.Masaki Noda), Springer Japan, pp1-219, 2010
  2. Okada T, Takeda S: Advances in molecular therapy research on dystrophin-deficient muscular dystrophy. In, Gene Therapy and Regulation (ed. by Roger.Bertolotti), World Scientific, NJ, 5(1), pp113-123, 2010

2009

  1. Ito N & Miyagoe-Suzuki Y : Neuronal NOS as a regulator of muscle mass. Muscle Cell Physiology, pp97-107, 2009, Osaka University Press.

2008

  1. Miyagoe-Suzuki Y, Uezumi A, Takeda S: Side population (SP) cells and skeletal muscle differentiation.Recent Advances of Skeletal Muscle Differentiation, Editors: Tsuchida K and Takeda S. Research Signpost , Kerala, India, pp 61-78, 2008

2007

  1. Miyagoe-Suzuki Y, Uezumi A, Takeda S: Side Population (SP) cells and skeletal muscle differentiation. Recent advances of skeletal muscle differentiation, Research Signpost, 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India, 2007

Review Articles

As of today, 2017.9.26

2017

  1. Miyagoe-Suzuki Y, Takeda S: Skeletal muscle generated from induced pluripotent stem cells - induction and application. World J Stem Cells. 9:89-97, 2017

2016

  1. Tanihata J, Takeda S: Changes in cytosolic Ca2+dynamics in the sarcoplasmic reticulum associated with the pathology of Duchenne muscular dystrophy. JPFSM. 5: 309-312, 2016
  2. Nitahara-Kasahara Y, Takeda S, Okada T:Inflammatory predisposition predicts disease phenotypes in muscular dystrophy. Inflammation and Regeneration. 36: 14, 2016
  3. Miyatake S, Shimizu-Motohashi Y, Takeda S, Aoki Y: Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors. Drug Des Devel Ther. 10: 2745-2758, 2016
  4. Kuraoka M, Takeda S: Serum osteopontin as a novel biomarker for muscle regeneration in Duchenne muscular dystrophy. Atlas of Science. July 1, 2016
  5. Shimizu-Motohashi Y, Miyatake S, Komaki H, Takeda S, Aoki Y: Recent advances in innovative therapeutic approaches for Duchenne muscular dystrophy: from discovery to clinical trials. Am J Transl Res. 8: 2471-2489, 2016

2015

  1. Aoki Y, Douglas AG, Wood MJ: Oligonucleotide therapies: the future of amyotrophic lateral sclerosis treatment? Neurodegener Dis Manag. 5: 93-95, 2015
  2. Hyzewicz J, Ruegg U, Takeda S: Comparison of Experimental Protocols of Physical Exercise for mdx Miceand Duchenne Muscular Dystrophy Patients. J Neuromuscul Dis. 2: 325-342, 2015
  3. Nichols B, Takeda S, Yokota T: Nonmechanical Roles of Dystrophin and Associated Proteins in Exercise, Neuromuscular Junctions, and Brains. Brain Sci. 5:275-298, 2015
  4. Ito N, Takeda S:Role of Ca2+ signaling in skeletal muscle hypertrophy and atrophy. J Phys Fitness Sports Med, 4: 171-176, 2015 DOI: 10.7600/jpfsm.4.171.

2014

  1. Nitahara-Kasahara Y, Takeda S, Okada T: Cell therapeutic approaches using multipotent mesencymal stromal cells for muscular dystrophy. Inflammation and Regeneration, 34(4): 198-205, 2014
  2. Kimura E, Nakamura H, Mitsuhashi S, Takeuchi F, Mori-Yoshimura M, Shimizu R, Komaki H, Hayashi YK, Nishino I, Kawai M, Takeda S: The infrastructure for the clinical research of muscular dystrophies: Remudy and MDCTN. Rinsho Shinkeigaku. 54: 1069-1070, 2014
  3. Watanabe Y, Miyagoe-Suzuki Y: Possibility of small-molecule-based pharmacotherapy for sarcopenia. J Phys Fitness Sports Med, 4 (1): 73-82, 2015

2013

  1. Ito N, Miyagoe-Suzuki Y, Takeda S: Molecular basis of muscle hypertrophy and atrophy: potential therapy for muscular dystrophy. J Sports Med Phys Fitness 2: 179-184, 201
  2. Saito T, Ishigaki K, Murakami T, Sato T, Kajino S, Takeda S, Osawa M: Identification of a Duplication Breakpoint in the DMD Gene Using Array Comparative Genomic Hybridization. Journal of Tokyo Women's Medical College 83: E20-E24. 2013
  3. Okada T, Takeda S: Current Challenges and Future Directions in Recombinant AAV-Mediated Gene Therapy of Duchenne Muscular Dystrophy. Pharmaceuticals (Basel) 6: 813-836.2013

2012

  1. Aoki Y, Nagata T, Takeda S: New Approach for Antisense Oligonucleotide-Mediated Exon Skipping in Duchenne Muscular Dystrophy. International Journal of Advanced Computer Science, 16: 521-526, 2012

2011

  1. Aoki Y, Shimizu Y, Nagata T, Takeda S: Challenges to oligonucleotides-based therapeutics, especially with regards to exon 51 skipping for Duchenne muscular dystrophy. Modeling, Simulation and Applied Optimization (ICMSAO). 2011.5775520.
  2. Nakamura A, Takeda S: Exon-skipping therapy for Duchenne muscular dystrophy. Lancet, 378: 546-547, 2011
  3. Aoki Y, Nagata T, Shimizu-Motohashi Y, Takeda S: Antisense oligonucleotide-mediated exon 51-skipping therapy for Duchenne muscular dystrophy. International Journal of Advanced Computer Science, Vol. 1, No. 5, 209-214, 2011

2010

  1. Nagata T, Takeda S:Antisense Oligos for Muscular Dystrophy. Rinsho Shinkeigaku.50:843-843,2010

2008

  1. Ozawa K, Sato K, Oh I, Ozaki K, Uchibori R, Obara Y, Kikuchi Y, Ito T, Okada T, Urabe M, Mizukami H, Kume A: Cell and gene therapy using mesenchymal stem cells (MSCs). J Autoimmun 30: 121-127, 2008
  2. Okada T, Ozawa K: Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy. Front Biosci. 13: 1887-1891, 2008
  3. Okada T, Ozawa K: Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy. Front Biosci. 13: 1887-1891, 2008

2007

  1. Suzuki N, Miyagoe-Suzuk Y, Takeda S: Gene therapy for Duchenne muscular dystrophy. Future Neurology 2(1): 87-96, 2007
  2. Okada T, Ozawa K: Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy. Front Biosci 13: 1887-1891, 2008

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