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2010
Suzuki N, Mizuno H, Warita H, Takeda S, Itoyama Y, Aoki M: Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis. J Neurol Sci: 2010 Epub ahead of print
Fukuda S, Morikawa D, Yamamoto Y, Yoshida T, Sumie N, Yamaguchi M, Ito T, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H: Genetic background affects properties of satellite cells and mdx phenotypes. Am J Pathol 176(5): 2414-2424, 2010
Uezumi A, Fukuda S, Yamamoto N, Takeda S, Tsuchida K: Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol 12: 143-152, 2010
2009
Matsumoto H, Maruse H, Sasazaki S, Fujiwara A, S Takeda, Ichihara N, Kikuchi T, Mukai F, Mannen H: Expression pattern of WWP1 in muscular dystrophic and normal chickens, J. Poult. Sci. 46: 95-99, 2009
Kobayashi M, Nakamura A, Hasegawa D, Fujita M, Orima H, Takeda S: Evaluation of dystrophic dog pathology by fat-suppressed T2-weighted imaging. Muscle Nerve. 40: 815-826, 2009
Cui R, Duan XL, Anderson GJ, Qiao YT, Yu P, Qian ZM, Yoshida K, Takeda S, Guo P, Yang ZL, Chang YZ : Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice. J Trace Elem Med Biol. 23: 290-299, 2009
Guo P, Cui R, Chang YZ, Wu WS, Qian ZM, Yoshida K, Qiao YT, Takeda S, Duan XL: Hepcidin, an antimicrobial peptide is downregulated in ceruloplasmin-deficient mice. Peptides. 30: 262-266, 2009
Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa ; A, Sakamoto K, Yamaguchi A: CCN3 and bone marrow cells. J Cell Commun Signal. 3: 135-145, 2009
Okada T, Nonaka-Sarukawa M, Uchibori R, Kinoshita K, Hayashita-Kinoh H, Nitahara-Kasahara Y, Takeda S, Ozawa K: Scalable purification of AAV1 and AAV8 vectors using dual ion-exchange adsorptive membranes. Hum Gene Ther. 20: 1013-1021, 2009
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T: Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading. Mol Cell Biol. 17:4798-4811, 2009Nakamura A, Takeda S: Exon-skipping therapy for Duchenne muscular dystrophy. Neuropathology. 29: 494-501, 2009
Uchibori R, Okada T, Ito T, Urabe M, Mizukami H, Kume A, Ozawa K: Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy. J Gene Med. 11: 373-381, 2009
Yokota T, Lu QL, Partridge T, Kobayashi M, Nakamura A, Takeda S, Hoffman E: Efficacy of systemic morpholino exon-skipping in duchenne dystrophy dogs. Ann Neurol 65: 667-676, 2009
Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada SI, Yamamoto H, Motohashi N, Suzuki Y, Takeda S, Heike T, Nakahata T: Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells. FASEB J 23: 1907-1919, 2009
Yokota T, Takeda S, Lu QL, Partridge TA, Nakamura A, Hoffman EP: A renaissance for antisense oligonucleotide drugs in neurology: exon skipping breaks new ground. Arch Neurol 66: 32-38, 2009
Miyazaki D, Yoshida K, Fukushima K, Nakamura A, Suzuki K, Sato T, Takeda S, Ikeda S: Characterization of deletion breakpoints in patients with dystrophinopathy carrying a deletion of exons 45-55 of the Duchenne muscular dystrophy (DMD) gene. J Hum Genet 54: 127-130, 2009
Miyagoe-Suzuki Y, Masubuchi N, Miyamoto K, Wada MR, Yuasa S, Saito F, Matsumura K, Kanesaki H, Kudo A, Manya H, Endo T, Takeda S: Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro. Mech Dev 126: 107-116, 2009
Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T: Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy. Hum Mol Genet 18: 621-31, 2009
Sekiguchi M, Zushida K, Yoshida M, Maekawa M, Kamichi S, Yoshida M, Sahara Y, Yuasa S, Takeda S, Wada K: A deficit of brain dystrophin impairs specific amygdala GABAergic transmission and enhances defensive behaviour in mice. Brain 132: 124-135, 2009
Ohshima S, Shin JH, Yuasa K, Nishiyama A, Kira J, Okada T, Takeda S: Transduction Efficiency and Immune Response Associated With the Administration of AAV8 Vector Into Dog Skeletal Muscle. Mol Ther 17: 73-80, 2009
Shibuya N, Tanaka M, Yoshida M, Ogasawara Y, Togawa T, Ishii K and Kimura H: 3-mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal 11: 703-714, 2009
2008
Segawa M, Fukada S, Yamamoto Y, Yahagi H, Kanematsu M, Sato M, Ito T, Uezumi A, Hayashi S, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H: Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis. Exp Cell Res 314: 3232-3244, 2008
Yuasa K, Hagiwara Y, Ando M, Nakamura A, Takeda S, Hijikata T: MicroRNA-206 is highly expressed in newly formed muscle fibers: implications regarding potential for muscle regeneration and maturation in muscular dystrophy. Cell Struct Funct 33: 163-169, 2008
Katsumata O, Honma T, Sanda M, Kamata A, Takeda S, Kondo H, Sakagami H: Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes. Brain Res 1234:44-49, 2008
Motohashi N, Uezumi A, Yada E, Fukada S, Fukushima K, Imaizumi K, Miyagoe-Suzuki, Y, Takeda S: Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts. Am J Pathol 173: 781-791, 2008
Sato K, Yokota T, Ichioka S, Shibata M, Takeda S: Vasodilation of intramuscular arterioles under shear stress in dystrophin-deficient skeletal muscle is impaired through decreased nNOS expression. Acta Myol 27:30-36, 2008
Nishiyama A, Ampong BN, Ohshima S, Shin JH, Nakai H, Imamura M, Miyagoe-Suzuki Y, Okada T, Takeda S: Recombinant adeno-associated virus type 8-mediated extensive therapeutic gene delivery into skeletal muscle of alpha-sarcoglycan-deficient mice. Hum Gene Ther 19: 719-730, 2008
Nakamura A, Yoshida K, Fukushima K, Ueda H, Urasawa N, Koyama J, Yazaki Y, Yazaki M, Sakai T, Haruta S, Takeda S, Ikeda S: Follow-up of three patients with a large in-frame deletion of exons 45-55 in the Duchenne muscular dystrophy (DMD) gene. J Clin Neurosci 15: 757-763, 2008
Hijikata T, Nakamura A, Isokawa K, Imamura M, Yuasa K, Ishikawa R, Kohama K,@Takeda S, Yorifuji H: Plectin 1 links intermediate filaments to costameric sarcolemma through {beta}-synemin, {alpha}-dystrobrevin and actin. J Cell Sci 121: 2062-2074, 2008
Matsumoto H, Maruse H, Inaba Y, Yoshizawa K, Sasazaki S, Fujiwara A, Nishibori M, Nakamura A, Takeda S, Ichihara N, Kikuchi T, Mukai F, Mannen H: The ubiquitin ligase gene (WWP1) is responsible for the chicken muscular dystrophy. FEBS Lett 582: 2212-2218, 2008
Urasawa N, Wada MR, Machida N, Yuasa K, Shimatsu Y, Wakao Y, Yuasa S, Sano T, Nonaka I, Nakamura A, Takeda S: Selective vacuolar degeneration in dystrophin deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. Circulation 117: 2437-2448, 2008
Tanihata J, Suzuki N, Miyagoe-Suzuki Y, Imaizumi K, Takeda S: Dowmstream utrophin enhancer is required for expression of utrophin in skeletal muscle. J Gene Med 10: 702-713, 2008
Nakatani M, Takehara Y, Sugino H, Matsumoto M, Hashimoto O, Hasegawa Y, Murakami T, Uezumi A, Takeda S, Noji S, Sunada Y, Tsuchida K: Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice. FASEB J 22: 477-487, 2008
Yuasa K, Nakamura A, Hijikata T, Takeda S: Dystrophin deficiency in canine X-linked muscular dystrophy in Japan (CXMDJ) alters myosin heavy chain expression profiles in the diaphragm more markedly than in the tibialis cranialis muscle. BMC Musculoskelet Disord 9: 1, 2008
Fukada S, Yamamoto Y, Segawa M, Sakamoto K, Nakajima M, Sato M, Morikawa D, Uezumi A, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H: CD90-positive cells, an additional cell population, produce laminin <alpha>2 upon transplantation to dy3k/dy3k mice. Exp Cell Res 314: 193-203, 2008
2007
Suzuki N, Motohashi N, Uezumi A, Fukada SI, Yoshimura T, Itoyama Y, Aoki M, Miyagoe-Suzuki Y, Takeda S. NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS. J Clin Invest.117(9): 2468-2476, 2007
Ikemoto M, Fukada SI, Uezumi A, Masuda S, Miyoshi H, Yamamoto H, Wada MR, Masubuchi N, Miyagoe-Suzuki Y, Takeda S. Autologous Transplantation of SM/C-2.6(+) Satellite Cells Transduced with Micro-dystrophin CS1 cDNA by Lentiviral Vector into mdx Mice. Mol Ther. 15(12): 2178-85, 2007
Fukada S, Uezumi A, Ikemoto M, Masuda S, Segawa M, Tanimura N, Yamamoto H, Miyagoe-Suzuki Y, Takeda S. Molecular Signature of Quiescent Satellite Cells In Adult Skeletal Muscle. Stem Cells 25(10): 2448-2459, 2007
Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Harada N, Hosaka T, Na kaya Y, Ishidoh K, Obata T, Ebina Y, Gu H, Takeda S, Kishi K, Nikawa T. Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes 56(10): 2511-2522, 2007
Yuasa K, Yoshimura M, Urasawa N, Ohshima S, Howell JM, Nakamura A, Hijikata T, Miyagoe-Suzuki Y, Takeda S. Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products. Gene Ther. 14(17): 1249-1260, 2007
Fukushima K, Nakamura A, Ueda H, Yuasa K, Yoshida K, Takeda S, Ikeda SI. Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ).BMC Musculoskelet Disord. 8(1): 54
Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, Takahashi T, Goto M, Mikami Y, Yasuda N, Akazawa H, Uezumi A, Takeda S, Komuro I. Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol. 176(3): 329-341, 2007
Ideno J, Mizukami H, Kakehashi A, Saito Y, Okada T, Urabe M, Kume A, Kuroki M, Kawakami M, Ishibashi S, Ozawa K: Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model. Int J Mol Med 19 (1): 75-79, 200
Takei Y, Mizukami H, Saga Y, Yoshimura I, Hasumi Y, Takayama T, Kohno T, Matsushita T, Okada T, Kume A, Suzuki M, Ozawa K: Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector. Int J Cancer 120 (2): 278-284, 2007
Nakata M, Okada T, Ozawa K, Yada T: Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. 353 (4): 1046-1051, 2007
Liu Y, Okada T, Nomoto T, Ke X, Kume A, Ozawa K, Xiao S: Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo. Exp Mol Med. 39 (2): 170-175, 2007
Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K: Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats. Circ Res. 101 (7): 734-741, 2007
Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Sakata Y, Shimada K, Ozawa K: Adeno associated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. Hypertension 50 (3): 531-536, 2007
Kobayashi M, Okada T, Murakami T, Ozawa K, Kobayashi E Morita T: Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems. Urology 70 (6): 1230-1236, 2007
2006
Yugeta N, Urasawa N, Fujii Y, Yoshimura M, Yuasa K, Nakamura A, Wada MR, Nakura M, Shimatsu Y, Tomohiro M,Takahashi A, Machida N, Wakao Y, Takeda S. Cardiac involvement in Beagle-based canine X-linked muscular dystrophy in Japan (CXMDJ): electrocardiographic, echocardiographic, and morphologic studies. BMC Cardiovasc Disord. 6: 47, 2006
Pramono ZA, Lai PS, Tan CL, Takeda S, Yee WC. Identification and characterization of a novel human dysferlin transcript: dysferlin_v1. Hum Genet. 120 (3): 410-419, 2006
Yokota T, Lu QL, Morgan JE, Davies KE, Fisher R, Takeda S, Partridge TA. Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration. J Cell Sci. 119 (Pt 13): 2679-2687, 2006
Suzue N, Nikawa T, Onishi Y, Yamada C, Hirasaka K, Ogawa T, Furochi H, Ksaka H, Ishidoh K, Gu H, Takeda S, Ishimaru N, Hayashi Y. Yamamoto H, Kishi K, Yasui N: Ubiquitin ligase Cbl-b down-regulate bone formation through supression of OGF-1 signaling in osteblasts during denervation. J Bone Miner Res. 21(5): 722-734, 2006
Shiga K, Yoshioka H, Matsumiya T, Kimura I, Takeda S, Imamura M. zeta-Sarcoglycan is a functional homologue of gamma-sarcoglycan in the formation of the sarcoglycan complex. Exp Cell Res. 312 (11): 2083-2092, 2006
Uezumi A, Ojima K, Fukada S, Ikemoto M, Masuda S, Miyagoe-Suzuki Y, Takeda S. Functional heterogeneity of side population cells in skeletal muscle. Biochemical and Biophysical Research Communications, 341: 864-873, 2006
Hagiwara Y, Fujita M, Imamura M, Noguchi S, Sasaoka T： Caveolin-3 deficiency decreases the gene expression level of osteopontin in mdx mouse skeletal muscle. Acta Myol. 25, 53-61, 2006
2005
Okano T, Yoshida K, Nakamura A, Sasazawa F, Oide T, Takeda S, Ikeda S. Chronic exercise accelerates the degeneration-regeneration cycle and downregulates insulin-like growth factor-1 in muscle of mdx mice. Muscle Nerve 32 (2): 191-199, 2005
Dezawa M, Ishikawa H, Itokazu Y, Yoshihara T, Hoshino M, Takeda S, Ide C, Nabeshima Y. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 309 (5732): 314-317, 2005
Nakamura A, Yoshida K, Ueda H, Takeda S, Ikeda S. Up-regulation of mitogen activated protein kinases in mdx skeletal muscle following chronic treadmill exercise. Biochim Biophys Acta. 1740 (3): 326-331, 2005
Mochizuki Y, Ojima K, Uezumi A, Masuda S, Yoshimura K, Takeda S. Participation of bone marrow-derived cells in fibrotic changes in denervated skeletal muscle. Am J Pathol. 166 (6): 1721-1732, 2005
Yang D, Bierman J, Tarumi YS, Zhong YP, Rangwala R, Proctor TM, Miyagoe-Suzuki Y, Takeda S, Miner JH, Sherman LS, Gold BG, Patton BL. Coordinate control of axon defasciculation and myelination by laminin-2 and -8. J Cell Biol. 168 (4): 655-666, 2005
Imamura M, Mochizuki Y, Engvall E, Takeda S. {epsilon}-Sarcoglycan compensates for lack of {alpha}-sarcoglycan in a mouse model of limb-girdle muscular dystrophy. Hum Mol Genet. 14 (6): 775-783, 2005
Takahashi J, Itoh Y, Fujimori K, Imamura M, Wakayama Y, Miyagoe-Suzuki Y, Takeda S. The utrophin promoter A drives high expression of the transgenic LacZ gene in liver, testis, colon, submandibular gland, and small intestine. J Gene Med. 7 (2): 237-248, 2005
Lu QL, Rabinowitz A, Chen YC, Yokota T, Yin H, Alter J, Jadoon A, Bou-Gharios G, Partridge T. Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles. Proc Natl Acad Sci U S A. 102 (1): 198-203, 2005
Shimatsu Y, Yoshimura M, Yuasa K, Urasawa N, Tomohiro M, Nakura M, Tanigawa M, Nakamura A, Takeda S: Major clinical and histopathological characteristics of canine X-linked muscular dystrophy in Japan, CXMDJ. Acta Myologica XXIV: 145-154, 2005
Ampong BN, Imamura M, Matsumiya T, Yoshida M, Takeda S: Instracellular localization of dysferlin and its association with the dihydropyridine receptor. Acta Myologica XXIV: 134-144, 2005
Hoshino Y, Uchida M, Shimatsu Y, Miyake M, Nagao Y, Minami N, Yamada M, Imai H: Developmental competence of somatic cell nuclear transfer embryos reconstructed from oocytes matured in vitro with follicle shells in miniature pig. Cloning Stem Cells 7: 17-26, 2005
Ozawa E, Mizuno Y, Hagiwara Y, Sasaoka T, Yoshida M: Molecular and cell biology of the sar coglycan complex. Muscle Nerve 32: 563-576, 2005
2004
Yoshimura M, Sakamoto M, Ikemoto M, Mochizuki Y, Yuasa K, Miyagoe-Suzuki Y, Takeda S. AAV vector-mediated microdystrophin expression in a relatively small percentage of mdx myofibers improved the mdx phenotype. Mol Ther. 10 (5): 821-828, 2004
Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T. Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. J Alzheimers Dis. 6 (5): 483-488, 2004
Ojima K, Uezumi A, Miyoshi H, Masuda S, Morita Y, Fukase A, Hattori A, Nakauchi H, Miyagoe-Suzuki Y, Takeda S. Mac-1(low) early myeloid cells in the bone marrow-derived SP fraction migrate into injured skeletal muscle and participate in muscle regeneration. Biochem Biophys Res Commun. 2004 321 (4): 1050-1061, 2004
Gawlik K, Miyagoe-Suzuki Y, Ekblom P, Takeda S, Durbeej M. Laminin alpha1 chain reduces muscular dystrophy in laminin alpha2 chain deficient mice. Hum Mol Genet. 13 (16): 1775-1784, 2004
Nishiyama A, Endo T, Takeda S, Imamura M. Identification and characterization of epsilon-sarcoglycans in the central nervous system. Brain Res Mol Brain Res. 125 (1-2): 1-12. 2004
Fukada S, Higuchi S, Segawa M, Koda K, Yamamoto Y, Tsujikawa K, Kohama Y, Uezumi A, Imamura M, Miyagoe-Suzuki Y, Takeda S, Yamamoto H. Purification and cell-surface marker characterization of quiescent satellite cells from murine skeletal muscle by a novel monoclonal antibody. Exp Cell Res. 296 (2): 245-255, 2004
Yuasa K, Fukumoto S, Kamasaki Y, Yamada A, Fukumoto E, Kanaoka K, Saito K, Harada H, Arikawa-Hirasawa E, Miyagoe-Suzuki Y, Takeda S, Okamoto K, Kato Y, Fujiwara T. Laminin alpha2 is essential for odontoblast differentiation regulating dentin sialoprotein expression. J Biol Chem. 279 (11): 10286-10292, 2004.
Munehira Y, Ohnishi T, Kawamoto S, Furuya A, Shitara K, Imamura M, Yokota T, Takeda S, Amachi T, Matsuo M, Kioka N, Ueda K: Alpha1-syntrophin modulates turnover of ABCA1. J Biol Chem. 279 (15): 15091-15095, 2004
Nikawa T, Ishidoh K, Hirasaka K, Ishihara I, Ikemoto M, Kano M, Kominami E, Nonaka I, Ogawa T, Adams G, Baldwin K, Yasui N, Kishi K, Takeda S: Skeletal muscle gene expression in space-flown rats. FASEB J. 18 (3): 522-5242004
Ishikawa-Sakurai M, Yoshida M, Imamura M, Davies KE, Ozawa E: ZZ domain is essentially required for the physiological binding of dystrophin and utrophin to beta-dystroglycan. Hum Mol Genet 13: 693-702, 2004
Mizuno Y, Guyon JR, Watkins SC, Mizushima K, Sasaoka T, Imamura M, Kunkel LM, Okamoto K： beta-Synemin localizes to regions of high stress in human skeletal myofibers. Muscle Nerve 30: 337-346, 2004
Shimatsu Y, Uchida M, Niki R, Imai H: Effects of a synthetic progestogen, altrenogest, on oestrus synchronisation and fertility in miniature pigs. Vet Rec 155: 633-635, 2004
