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Positive valence system-focused Cognitve behavior Therapy for anhedonia

What is Anhedonia?

Anhedonia includes a decline in positive emotions, a decline in motivation, a decrease in sensitivity to rewards, and a loss of pleasure.
Although it is one of the central symptoms of depression, it is a symptom not only found in depression but also in various diseases (eg, schizophrenia, obsessive compulsive disorder, post-traumatic stress disorder, etc.).

In fact, it has been found it difficult to improve with medicine and conventional psychotherapy.
Under the recently proposed Research Domain Criteria (RDoC), Anhedonia is classified as a positive system failure / disorder. In other words, the positive system is not working.

 

What is PoCoT?

PoCot session is once a week for 50 to 60 minutes, for a total of eight sessions.
PoCot is a cognitive-behavioral therapy that focuses on the positive valence system, focusing on the “feelings of mind” and trying to improve the symptoms of anhedonia by restoring the positive system.

At PoCot, a client starts with a good rest, healing, and curing, then gradually regains balance. The program is designed to restore comfortable mind in a natural flow.

About hypersonic effect

The hypersonic effect is that acoustic information rich in ultra high frequency components exceeding the upper limit of the human audible area activates the neural activity in the deep brain including the reward system neural circuit and exerts systemic influence on the human body. This is assumed to enhance the effect of PoCot.

Participant candidates

<Inclusion Criteria>

Have deprssion symptom(GRID-HAMD≧8)
Have anhedonia symptom(SHAPS≧20)
18+ years old

<Exclusion Criteria>

Currently, those with psychotic disorder
Currently, those with a gonorrhea episode
Currently, those with severe substance use disorders
Currently, those with serious thought of death
Those with physical disease and/or cognitive dysfunction that have difficulty in treatment
Those who have problems in performing cognitive behavioral therapy

* Request to your doctor *
With regard to drug therapy, please do not change the type and dosage of medicine during the intervention period.

 

PoCot clinical trial flow

References

  • ・Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., & Dour, H. J. (2016). Treatment for anhedonia: A neuroscience driven approach. Depression and Anxiety, 33, 927–938.
  • ・Winer et al. (2017). Mapping the relationship between anxiety, anhedonia, and depression. Journal of Affective Disorders, 15, 289-296.


National Center of Neurology and PsychiatryNational Center of Neurology and Psychiatry National Center Hospital National Institute of Neuroscience

National Institute of Mental Health Translational Medical Center Medical Genome Center Integrative Brain Imaging Center


National Center of Neurology and PsychiatryNational Center of Neurology and Psychiatry National Center Hospital National Institute of Neuroscience National Institute of Mental Health

Translational Medical Center Medical Genome Center Integrative Brain Imaging Center

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