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Glia-neuron interaction
We aim to elucidate the biological and pathological significance of astrocytes, oligodendrocytes and microglia. We previously showed that lack of glial glutamate transporters causes epilepsy in mice. Furthermore, we showed that modification of glia-neuron interactions prevents neurodegeneration in the retina. More recently, we have studied in vivo function of glial cells by focusing on glial glutamate transporters and GPCRs.

Selected publications
  1. Tanaka, K., Watase, K., Manabe, T., et al., Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science, 276, 1699-1702, 1997
  2. Harada, T., Harada, C., Nakayama, N., et al., Modification of glial-neuronal interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron, 26, 533-541, 2000
  3. Hagino, Y., Kariura, Y., Manago, Y., Amano, T., Wang, B., Sekiguchi, M., Nishikawa, K., Aoki, S., Wada, K. and Noda, M. Heterogeneity and potentiation of AMPA-type of glutamate receptors in rat cultured microglia. Glia, 47, 68-77, 2004
  4. Furuta, A., Takashima, S., Yokoo, H., Rothstain, J.D., Wada, K. and Iwaki, T. Expression of glutamate transporter subtypes during normal human corticogenesis and type II lissencephaly. Dev. Brain Res. 155, 155-164, 2005
  5. Fukazawa, N., Ayukawa, K., Nishikawa, K., Ohashi, H., Ichihara, N., Hikawa, Y., Abe, T., Kudo, Y., Kiyama, H., Wada, K. and Aoki, S. Identiofication and functional characterization of mouse TPO1 as a myelin membrane protein. Brain Res, 1070, 1-14, 2006
  6. Nishimoto, M., Furuta, A., Aoki, S., Kudo, Y., Miyakawa, H. and Wada, K. PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells. Glia, 55, 317-327, 2007
  7. Noda, M., Sasaki, K., Ifuku, M., Wada, K. Multifunctional effects of bradykinin on glial cells in relation to potential anti-inflammatory effects. Neurochem. Int., 51, 185-191, 2007 review, Epub ahead of print, 2007 Jun 27
  8. Yamauchi, R., Wada, E., Kamichi, S., Yamada, D., Maeno, H., Delawary, M., Nakazawa, T., Yamamotot, T., Wada, K. Neurotensin type2 receptor is involved in fear memory in mice. J. Neurochem., 102, 1669-1676, 2007.

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