A ) Original paper


Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W: Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibits its ability to produce beta-amyloid protein. Eur. J. Neurosci. 24, 1237-1244, 2006.PubMed

Summary of the paper.
We identified reticulon 4-B (RTN4-B or Nogo-B) as a BACE1-associated membrane protein, and confirmed that BACE1 physically interacts with RTN4-B, RTN4-C (Nogo-C) and RTN3. We further showed that the catalytic domain of BACE1 is not required for its interaction with the reticulons and that overexpression of the reticulons inhibits the beta-cleavage of amyloid precursor protein to produce amyloid beta-protein. The data suggest that RTN4-B/C and RTN3 play important roles in the regulation of BACE1 activity.

Araki W, Saito S, Takahashi-Sasaki N, Shiraishi H, Komano H, Murayama KS: Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif. J. Mol. Neurosci. 29, 35-44, 2006PubMed

Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M: Altered localization of amyloid precursor protein under endoplasmic reticulum stress. Biochem. Biophys. Res. Comm. 344, 525-30, 2006.

Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H: Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex. Genes Cells 11, 83-93, 2006.


Murayama KS, Kametani F, Araki W: Extracellular release of BACE1 holoproteins from human neuronal cells. Biochem. Biophys. Res. Comm. 338, 800-807, 2005.PubMed

Lakshmana MK, Araki W, Tabira T: Amyloid beta peptide binds a novel death-inducing protein, AB-DIP. FASEB J. 19, 1362-1364, 2005.PubMed

Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H: Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein. Mol. Brain Res. 137, 70-76, 2005.

Hasegawa T, Ukai W, Jo DG, Xu X, Mattson MP, Nakagawa M, Araki W, Saito T, Yamada T: Homocysteic acid induces intraneuronal accumulation of neurotoxic Ab42: Implications for the pathogenesis of Alzheimer's disease. J. Neurosci. Res. 80, 869-876, 2005.

Saito S, Takahashi-Sasaki N, Araki W: Identification and characterization of a novel human APH-1b splice variant lacking exon 4. Biochem. Biophys. Res. Comm. 330, 1068-1072, 2005.PubMed

Saito S, Araki W: Expression profiles of two human APH-1 genes and their roles in the formation of presenilin complexes. Biochem. Biophys. Res. Comm. 327, 18-22, 2005.PubMed


Takeda K, Araki W, Akiyama H, Tabira T: Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain. FASEB J. 18, 1755-1757, 2004.PubMed

Summary of the paper:
We have shown for the first time that the caspase-cleavage of amyloid precursor protein leads to increased production of amino-truncated Abeta5-40/42, and this Abeta species is deposited in Alzheimer's disease brain tissue. These findings highlight the significance of amino-truncated Abeta in the pathogenesis of Alzheimer's disease.

Watanabe N, Araki W, Chui D-H, Makifuchi T, Ihara Y, Tabira T: Glypican-1 as an Abeta binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. FASEB J. 18, 1013-1015, 2004; (FJ express articles) published Apr 14, 2004.PubMed

Takeda K, Araki W, Tabira T: Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2. Eur. J. Neurosci. 19, 258-264, 2004.PubMed

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