TOP RESEARCH STAFF PUBLICATIONS ACCESS

A ) 原著 (English only)

 

2017

Araki W, Hattori K, Kanemaru K, Yokoi Y, Omachi Y, Takano H, Sakata M, Yoshida S, Tsukamoto T, Murata M, Saito Y, Kunugi H, Goto YI, Nagaoka U, Nagao M, Komori T, Arima K, Ishii K, Murayama S, Matsuda H, Tachimori H, Araki YM, Mizusawa H: Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders. Biomarker Res 5:28, 2017 PubMed  NCNPトピックス

 

Mamada N, Tanokashira D, Ishii K, Tamaoka A, Araki W: Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein. Biochem Biophys Res Comm 486: 321-328, 2017 PubMed

Tanokashira D, Mamada N, Yamamoto F, Taniguchi K, Tamaoka A, Lakshmana MK, Araki W: The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model. Mol Brain 10:4, 2017 PubMed

NCNPプレスリリース

 

2015

Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W: Amyloid beta-protein oligomers upregulate the beta-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons. Mol Brain 8: 73, 2015  PubMed

NCNPプレスリリース

Tanokashira D, Motoki K, Minegishi S, Hosaka A, Mamada N, Tamaoka A, Okada T, Lakshmana MK, Araki W: LRP1 down-regulates the Alzheimer's beta-secretase BACE1 by modulating its intraneuronal trafficking. eNeuro 2: 0006-15, 2015 PubMed

Araki W, Tamaoka A: Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism. Front Biosci (Landmark Ed), 20, 314-324, 2015 PubMed

2014

Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E: Nardilysin prevents amyloid plaque formation by enhancing a-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging 35(1), 213-222, 2014 PubMed

Araki W, Minegishi S, Motoki K, Kume H, Hohjoh H, Araki YM, Tamaoka A: Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway. Mol Neurobiol 50, 1049-1058, 2014 PubMed (細胞モデルを用いて、TDP-43の疾患関連変異はプロテアソーム経路を介して、そのタンパク代謝回転を促進することを示しました。)

2013

Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin R-W, Tamaoka A, Ogino K: Reduction of beta-amyloid accumulation by reticulon 3 in transgenic mice. Curr Alzheimer Res 10: 135-142, 2013 PubMed(トランスジェニックマウスモデルを用いて、Reticulon3の発現増加がBACE1活性の変調を介して、βアミロイド蓄積を抑制することを明らかにしました。)

Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A: Statins reduce amyloid beta-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. Neurochem Res 38: 589-600, 2013PubMed (スタチンはコレステロール非依存的機序により、アミロイド前駆体タンパクの成熟化、リン酸化の変化を介して、培養神経細胞のβアミロイド産生を低下させることを示しました。)

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