Pulication List: Original articles

1)Miyake S, Yagita H, Maruyama T, Hashimoto H, Miyasaka N Okumura K: 1 Integrin-mediated interaction with extracellular matrix protein regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients. J Exp Med 177: 863-868, 1993
2)Maruyama T, Saito I, Miyake S, Hashimoto H, Sato K, Yagita H, Okumura K Miyasaka N:A possible role of two hydrophobic amino acids in antigen recognition by synovial T cells in rheumatoid arthritis. Eur J Immunol 23:2059-2065, 1993
3)Miyake S, Sakurai T, Okumura K, Yagita H:Identification of collagen and laminin receptor integrins on murine lymphocytes. Eur J Immunol 24: 2000-2005, 1994
4)Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H:p120cbl is major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of Phosphatidylinositol 3-kinase. J Biol Chem 271:3187-3194, 1996
5)Miyake S*, Fukazawa T*, Band V, Band H:Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J Biol Chem 271:14554-14559, 1996 * Eaqual contribution.
6)Lupher ML, Reedquist KA, Miyake S, Langdon WY Band H:A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J Biol Chem 271:24063-24068, 1996
7)Tokano Y, Miyake S, Kayagaki N, Nozawa K, Morimoto S, Azuma M, Yagita H, Takasaki Y, Okumura K, Hashimoto H:Soluble Fas molecule in the serum of patients with systemic lupus erythematosus. J Clin Immunol 16:261-265, 1996
8)Bonita D, Miyake S, Lupher ML, Langdon WY, Band H:Phophotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha singaling cascade by transforming mutants of Cbl:Implications for Cbl's function and oncogenicity. Mol Cell Biol 17:4597-4610, 1997
9)Miyake S, Lupher ML, Druker B, Band H:The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet derived growth factor receptor . Proc Natl Acad Sci USA 95:7927-7932, 1998
10) Lupher ML, Rao N, Andoniou CE, Miyake S, Band H:Cbl-mediated negative regulation of the Syk tyrosine kinase: A critical role for Cbl PTB domain binding to Syk pY323. J Biol Chem 273:35273-35281, 1998
11)Miyake S, Mullane KP, Douillard P, Band H:Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. J Biol Chem 274:16619-16628, 1999
12)Lill NL, Douillard P, Awwad R, Ota S, Lupher ML, Miyake S, Meissner NS, Hsu V, Band H:The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor. J Biol Chem 275:367-377, 2000
13)Rosenkranz S, Ikuno Y, Leong FL, Klinghoffer RA, Miyake S, Band H, Kazlauskas A. Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. J Biol Chem 275:9620-9627, 2000
14)Pal E, Tabira T, Kawano T, Taniguchi M, Miyake S, Yamamura T:Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V14 natural killer (NK) T cells. J Immunol 166:662-668, 2001
15)Takahashi K, Miyake S, Kondo T, Terao K, Hatakenaka M, Hashimoto S, Yamamura T:Natural killer type 2 bias in remission of multiple sclerosis. J Clin Invest 107:R23-R29, 2001
16)Miyake S*, Miyamoto K*, Yamamura T:A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 of natural killer T cells. Nature 413: 531-534, 2001 *Eaqual contribution.
17)Miyamoto K, Oka N, Kawasaki T, Miyake S, Yamamura T, Akiguchi I:New cyclooxygenase-2 inhibitors for treatment of experimental autoimmue neuritis. Muscle Nerve 25:280-282, 2002
18)Gumperz J, Miyake S, Yamamura T, Brenner MB:Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 195:625-36, 2002
19) Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H:Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci USA 99:3794-3799, 2002
20)Araki M, Kondo T, Gumperz JE, Brenner MB, Miyake S, Yamamura T:Th2 bias of CD4+ natural killer T cells derived from multiple sclerosis in remission. Int Immunol 15:279-288, 2003
21)Miyamoto K, Miyake S, Schachner M, Yamamura T:Heterozygous null mutation of myelin protein zero (P0) enhances susceptibility to autoimmune neuritis targeting P0 peptide. Eur J Immunol 33:656-665, 2003
22)Koike F, Satoh J-i, Miyake S, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T:Microarray analysis identifies interferon -regulated genes in multiple sclerosis. J Neuroimmunol 139:109-118, 2003
23)Bedoui S, Miyake S, Miyamoto K, Oki S, Lin Y, Kawamura N, Beck-Sickinger A, von Horsten S, Yamamura T:Neuropeptide Y (NPY) suppresses experimental autoimmune encephalomyelitis: NPY Y1 receptor-specific inhibition of autoreactive Th1 responsese in vivo. J Immunol 171:3451-3458, 2003
24)Nakamura T, Sonoda K-H, Faunce DE, Gumperz J, Yamamura T, Miyake S, Stein-Streilein J:CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site. J Immunol 171:1266-1271, 2003
25)Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S:Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by V14J18 natural TCR. J Immunol 171:4539-4551, 2003
26)Chiba A, Oki S, Miyamoto K, Hashimoto H, Yamamura T, Miyake S:Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide. Arthritis Rheum 50:305-313, 2004
27)Oki S, Chiba A, Yamamura T and Miyake S:The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest 113:1631-1640, 2004
28)Takahashi T, Miyake S, Endoh M, Yamamura T:The regulatory role for natural killer cells in the "smoldering" state of multiple sclerosis. Brain 127:1917-1927, 2004
29)Mizuno M, Masumura M, Tomi C, Chiba S, Oki S, Yamamura T, Miyake S:Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice. J Autoimmun 23:293-300, 2004
30)Nakai Y, Iwabuchi K, Fujii S, Ishimori N, Dashtsoodol N, Watano K, Mishima T, Iwabuchi C, Kato K, Tanaka S, Bezbradica JS, Nakayama T, Tanigchi M, Miyake S, Yamamura T, Kitabatake A, Joyce S, Van Kaer L, Onoe K:Natural killer T cells accelerate atherogenesis in mice. Blood 104:2051-2059, 2004
31)Satoh J-i, Nakanishi M, Koike F, Miyake S, Yamamuto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T:Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. Neurobiol Dis 18:537-550, 2005
32)Ueno Y, Tanaka S, Sumii M, Miyake S, Tazuma S, Taniguchi M, Yamamura T, Chayama K:Single dose of OCH improves mucosal Th1/Th2 cytokine balance and prevents experimental colitis in the presence of V14 NKT cells in mice. Inflamm Bowel Disease 11:35-41, 2005
33)Hashimoto D, Asakura S, Miyake S, Yamamura T, van Kaer L, Liu C, Tanimoto M, Teshima T:Stimulation of host natural killer T cells by synthetic glycolipid regulates acute graft-versus-host disease by inducint Th2 polarization of donor T cells. J Immunol 174:551-556, 2005
34)Murata K, Toba T, Nakanishi K, Takahashi B, Yamamura T, Miyake S, Annoura H:Total synthesis of an immunosuppressive glycolipid, (2S,3S,4R)-1-O- (alpha-d- galactosyl)-2-tetracosanoylamino-1,3,4-nonanetriol. J Org Chem 70:2398-2401, 2005
35)Yu KO, Im JS, Molano A, Dutronc Y, Illarionov PA, Forestier C, Fjiwara N, Arias I, Miyake S, Yamamur T, Chang YT, Besra GS, Porcellli SA:Modulation of CD1d-restricted NKT cell responses by using N-acylvariants of -galactosylceramides. Proc Natl Acad Sci USA 102:3383-3388, 2005
36)Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K:IFN--mediated negative feedback regulation of NKT cell function by CD94/NKG2. Blood 106:184-192, 2005
37)Chiba A, Kaieda S, Oki S, Yamamura T, Miyake S:The involvement of V14 NKT cells in the pathogenesis of murine models of arthritis. Arthritis Rheum 52:1941-1948, 2005
38)Toba T, Murata K, Yamamura T, Miyake S, Annoura H:A concise synthesis of (3S,4S,5R)-1-(-D-galactopyranosyl)-3-tetracosanoylamino-4,5-decanediol, C-glycoside analogue of immunomodulating@-galactosylceramide OCH. Tetrahedron Letters 46:5043-5047, 2005
39)Ronet C, Darche S, de Moraes ML, Miyake S, Yamamura T, Louis JA, Kasper LH, Buzoni-Gatel D:NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii. J Immunol 175: 899-908, 2005
40)Oki S, Tomi C, Yamamura T, Miyake S:Preferential Th2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production inflammatory cytokines by bystander cells in vivo. Int Immunol 17:1619-1629, 2005
41)Pyz E, Naidenko O, Miyake S, Yamamura T, Berberich I, Cardell S, Kronenberg M, Herrmann T:The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR. J Immunol 176:7447-7455, 2006
42)Miyamoto K, Miyake S, Mizuno M, Oka N, Kusunoki S, Yamamura T:Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2 independent pathway. Brain 129:1984-1992, 2006
43)Croxford JL, Miyake S, Huang Y-Y, Shimamura M, Yamamura T:Invariant V19i T cells regulate autoimmune inflammation. Nat Immunol 7:987-994, 2006
44)Aranami T, Miyake S, Yamamura T:Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis. J Immunol 177:5659-5667, 2006
45)Satoh J, Nakanishi M, Koike F, Onoue H, Aranami T, Ymamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Saito T, Ohta M, Miyake S, Kanda T, Fukazawa T, Yamamua T:T cell gene expression profiling identifies distinct subgroupus of Japanese multiple sclerosis patients. J Neuroimmunol 174:108-118, 2006
46)Toba T, Murata K, Nakanishi K, Takahashi B, Takemoto N, Akabane M, Nakatsuka T, Imajo S, Yamamura T, Miyake S and Annoura H:Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs. Bioorganic Med Chem Let 17:2781-2784, 2007
47)Kaieda S, Tomi C, Oki S, Yamamura T, Miyake S:Activation of iNKT cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis. Arthritis Rheum 56:1836-1845, 2007
48)Sakuishi K, Oki S, Araki M, Porcelli SA, Miyake S, Yamamura T:Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation. J Immunol 179:3452-3462, 2007
49)Ambrosino E, Terabe M, Halder RC, Peng J, Takaku S, Miyake S, Yamamura T, Kumar V, Berzofskky:Cross-regulation between Type I and Type II NKT cells in regulating turmor immunity: A new immunoregulatory axis. J Immunol 179:5126-5136, 2007
50)Dondji B, Deak E, Goldsmith-Pestana K, Perez-Jimenez E, Esteban M, Miyake S, Yammaura T, McMahon-Pratt D:Intradermal NKT cell activation during DNA priming in heterologous prime-boost vaccination enhances T cell responses and protection against Leishmania. Eur J Immunol 38:706-19, 2008
51)Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T:Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc Natl Acad Sci USA 105:8381-8386, 2008
52)Sekine C, Sugihara T, Miyake S, Hirai H, Yoshida M, Miyasaka N, Kohsaka H. Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors. J Immunol 180:1954-1961, 2008
53)Yokote H, Miyake S, Croxford JL, Oki S, Mizusawa H, Yamamura T. NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Ame J Patho 173:1714-23, 2008
54)Theil MM, Miyake S, Mizuno M, Tomi C, Croxford J, Hosoda H, Theil J, von Horsten S, Yokote H, Chiba A, Lin Y, Oki S, Akamizu T, Kanagawa K, Yamamura T:Suppression of experimental autoimmune encephalomyelitis by Ghrelin. J Immunol 83(4):2859-66, 2009
55)Fujia M, Otsuka T, Mizuno M, Tomi C, Yamamura T Miyake S. Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via iNKT cell-dependent mechanism. Ame J Patho 175(3):1116-23, 2009
56)Noto D, Takahashi K, Miyake S, Yamada M. In vitro differentiation of lineage-negative bone marrow cells into microglia-like cells. Eur.J.Neuroscience, 31:1155-63, 2010
57)Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S,Okamoto T, Ogawa M, Toda T, Yamamura T. Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc Natl Acad Sci USA@108(9):3701-3706, 2011
58)Miyazaki Y, Miyake S, Chiba A, Lantz O, Yamamura T : Mucosal-associated invariant T cells regulate T helper type 1 response in multiple sclerosis. Int. Immunol. Advance Access published June 28, 2011

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