室長 長野　清一

個人写真

学歴

  • 1992年　大阪大学医学部医学科卒業
  • 2000年　大阪大学大学院医学系研究科修了　博士（医学）

職歴

  • 1992年?1996年　大阪大学医学部附属病院、関西労災病院、大阪厚生年金病院にて臨床研修
  • 2000年　大阪大学医学部附属病院神経内科医員
  • 2001年?2003年　米国マサチューセッツ総合病院／ハーバード大学遺伝学・老化研究部門研究員
  • 2007年　大阪大学大学院医学系研究科神経内科学助教
  • 2010年7月より現職

研究テーマ

  1. 神経内科での診療の経験から大学院生時より一貫してALSの研究をしてきました。この疾患の治療に貢献できる成果を夢見て日々悪戦苦闘しています。

好きなこと

  • 知らない町・道を探索（放浪？）すること

着任前の実績

  • Kishigami H, Nagano S, Bush AI, Sakoda S.
    Monomerized Cu, Zn-superoxide dismutase induces oxidative stress through aberrant Cu affinity.
    Free Radic Biol Med 48, 945-952, 2010.

  • Nagano S, Bush AI. Sensitive, selective and irreversible inhibition of cyclooxygenase-2 activity by copper. ChemMedChem 3, 223-225, 2008.

    Watanabe S, Nagano S, Duce J, Kiaei M, Li QX, Tucker SM, Tiwari A, Brown RHJ, Beal MF, Hayward LJ, Culotta VC, Yoshihara S, Sakoda S, Bush AI. Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
    Free Radic Biol Med 42, 1534-1542, 2007.

  • Sumi H, Nagano S, Fujimura H, Kato S, Sakoda S. Inverse correlation between the formation of mitochondria-derived vacuoles and Lewy-body-like hyaline inclusions in G93A superoxide-dismutase-transgenic mice.
    Acta Neuropathol 112, 52-63, 2006.

  • Yamamoto Y, Nakamori M, Konaka K, Nagano S, Shimazaki H, Takiyama Y, Sakoda S. Sacsin-related ataxia caused by the novel nonsense mutation Arg4325X.
    J Neurol 253, 1372-1373, 2006.

  • Ouyang Y, Takiyama Y, Sakoe K, Shimazaki H, Ogawa T, Nagano S, Yamamoto Y, Nakano I. Sacsin-related ataxia (ARSACS): expanding the genotype upstream from the gigantic exon.
    Neurology 66, 1103-1104, 2006.

  • Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, Shawlot W, Hayashizaki Y, Westphal H, Behringer RR, Matsuda Y, Sakoda S, Kondoh H, Sasaki H. Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.
    Development 132, 2535-2546, 2005.

  • Puglielli L, Friedlich AL, Setchell KDR, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Cholesterol oxidase mimetic activity of Alzheimer's disease beta-amyloid.
    J Clin Invest 115, 2556-2563, 2005.

  • Yamamoto Y, Hiraoka K, Araki M, Nagano S, Shimazaki H, Takiyama Y, Sakoda S. Novel compound heterozygous mutations in sacsin-related ataxia.
    J Neurol Sci 239, 101-104, 2005.

  • Sato T, Nakanishi T, Yamamoto Y, Andersen PM, Ogawa Y, Fukada K, Zhou Z, Aoike F, Sugai F, Nagano S, Hirata S, Ogawa M, Nakano R, Ohi T, Kato T, Nakagawa M, Hamasaki T, Shimizu A, Sakoda S. Rapid disease progression correlates with instability of mutant SOD1 in familial ALS.
    Neurology 65, 1954-1957, 2005.

  • Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.
    J Biol Chem 279, 14673-14678, 2004.

  • Sato T, Yamamoto Y, Nakanishi T, Fukada K, Sugai F, Zhou Z, Okuno T, Nagano S, Hirata S, Shimizu A, Sakoda S. Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses.
    J Neurol Sci 218, 79-83, 2004.

  • Nagano S, Fujii Y, Yamamoto T, Taniyama M, Fukada K, Yanagihara T, Sakoda S. The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice.
    Exp Neurol 179, 176-180, 2003.

  • Nagano S, Satoh M, Sumi H, Fujimura H, Tohyama C, Yanagihara T, Sakoda S. Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner.
    Eur J Neurosci 13, 1363-1370, 2001.

  • Fukada K, Nagano S, Satoh M, Tohyama C, Nakanishi T, Shimizu A, Yanagihara T, Sakoda S. Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice.
    Eur J Neurosci 14, 2032-2036, 2001.

  • Nagano S, Ogawa Y, Yanagihara T, Sakoda S. Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice.
    Neurosci Lett 265, 159-162, 1999.

  • Yamamoto Y, Yoshikawa H, Nagano S, Kondoh G, Sadahiro S, Gotow T, Yanagihara T, Sakoda S. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin.
    Eur J Neurosci 11, 847-855, 1999.