| 1) | Miyake S, Yagita H, Maruyama T, Hashimoto H, Miyasaka N Okumura K: 1 Integrin-mediated interaction with extracellular matrix protein regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients. J Exp Med 177: 863-868, 1993 |
| 2) | Maruyama T, Saito I, Miyake S, Hashimoto H, Sato K, Yagita H, Okumura K Miyasaka N:A possible role of two hydrophobic amino acids in antigen recognition by synovial T cells in rheumatoid arthritis. Eur J Immunol 23:2059-2065, 1993 |
| 3) | Miyake S, Sakurai T, Okumura K, Yagita H:Identification of collagen and laminin receptor integrins on murine lymphocytes. Eur J Immunol 24: 2000-2005, 1994 |
| 4) | Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H:p120cbl is major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of Phosphatidylinositol 3-kinase. J Biol Chem 271:3187-3194, 1996 |
| 5) | Miyake S*, Fukazawa T*, Band V, Band H:Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J Biol Chem 271:14554-14559, 1996 * Eaqual contribution. |
| 6) | Lupher ML, Reedquist KA, Miyake S, Langdon WY Band H:A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J Biol Chem 271:24063-24068, 1996 |
| 7) | Tokano Y, Miyake S, Kayagaki N, Nozawa K, Morimoto S, Azuma M, Yagita H, Takasaki Y, Okumura K, Hashimoto H:Soluble Fas molecule in the serum of patients with systemic lupus erythematosus. J Clin Immunol 16:261-265, 1996 |
| 8) | Bonita D, Miyake S, Lupher ML, Langdon WY, Band H:Phophotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha singaling cascade by transforming mutants of Cbl:Implications for Cbl's function and oncogenicity. Mol Cell Biol 17:4597-4610, 1997 |
| 9) | Miyake S, Lupher ML, Druker B, Band H:The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet derived growth factor receptor α. Proc Natl Acad Sci USA 95:7927-7932, 1998 |
| 10) | Lupher ML, Rao N, Andoniou CE, Miyake S, Band H:Cbl-mediated negative regulation of the Syk tyrosine kinase: A critical role for Cbl PTB domain binding to Syk pY323. J Biol Chem 273:35273-35281, 1998 |
| 11) | Miyake S, Mullane KP, Douillard P, Band H:Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. J Biol Chem 274:16619-16628, 1999 |
| 12) | Lill NL, Douillard P, Awwad R, Ota S, Lupher ML, Miyake S, Meissner NS, Hsu V, Band H:The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor. J Biol Chem 275:367-377, 2000 |
| 13) | Rosenkranz S, Ikuno Y, Leong FL, Klinghoffer RA, Miyake S, Band H, Kazlauskas A. Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. J Biol Chem 275:9620-9627, 2000 |
| 14) | Pal E, Tabira T, Kawano T, Taniguchi M, Miyake S, Yamamura T:Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of Vα14 natural killer (NK) T cells. J Immunol 166:662-668, 2001 |
| 15) | Takahashi K, Miyake S, Kondo T, Terao K, Hatakenaka M, Hashimoto S, Yamamura T:Natural killer type 2 bias in remission of multiple sclerosis. J Clin Invest 107:R23-R29, 2001 |
| 16) | Miyake S*, Miyamoto K*, Yamamura T:A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 of natural killer T cells. Nature 413: 531-534, 2001 *Eaqual contribution. |
| 17) | Miyamoto K, Oka N, Kawasaki T, Miyake S, Yamamura T, Akiguchi I:New cyclooxygenase-2 inhibitors for treatment of experimental autoimmue neuritis. Muscle Nerve 25:280-282, 2002 |
| 18) | Gumperz J, Miyake S, Yamamura T, Brenner MB:Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 195:625-36, 2002 |
| 19) | Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H:Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci USA 99:3794-3799, 2002 |
| 20) | Araki M, Kondo T, Gumperz JE, Brenner MB, Miyake S, Yamamura T:Th2 bias of CD4+ natural killer T cells derived from multiple sclerosis in remission. Int Immunol 15:279-288, 2003 |
| 21) | Miyamoto K, Miyake S, Schachner M, Yamamura T:Heterozygous null mutation of myelin protein zero (P0) enhances susceptibility to autoimmune neuritis targeting P0 peptide. Eur J Immunol 33:656-665, 2003 |
| 22) | Koike F, Satoh J-i, Miyake S, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T:Microarray analysis identifies interferon β-regulated genes in multiple sclerosis. J Neuroimmunol 139:109-118, 2003 |
| 23) | Bedoui S, Miyake S, Miyamoto K, Oki S, Lin Y, Kawamura N, Beck-Sickinger A, von Horsten S, Yamamura T:Neuropeptide Y (NPY) suppresses experimental autoimmune encephalomyelitis: NPY Y1 receptor-specific inhibition of autoreactive Th1 responsese in vivo. J Immunol 171:3451-3458, 2003 |
| 24) | Nakamura T, Sonoda K-H, Faunce DE, Gumperz J, Yamamura T, Miyake S, Stein-Streilein J:CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site. J Immunol 171:1266-1271, 2003 |
| 25) | Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S:Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Vα14Jα18 natural TCR. J Immunol 171:4539-4551, 2003 |
| 26) | Chiba A, Oki S, Miyamoto K, Hashimoto H, Yamamura T, Miyake S:Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide. Arthritis Rheum 50:305-313, 2004 |
| 27) | Oki S, Chiba A, Yamamura T and Miyake S:The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest 113:1631-1640, 2004 |
| 28) | Takahashi T, Miyake S, Endoh M, Yamamura T:The regulatory role for natural killer cells in the "smoldering" state of multiple sclerosis. Brain 127:1917-1927, 2004 |
| 29) | Mizuno M, Masumura M, Tomi C, Chiba S, Oki S, Yamamura T, Miyake S:Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice. J Autoimmun 23:293-300, 2004 |
| 30) | Nakai Y, Iwabuchi K, Fujii S, Ishimori N, Dashtsoodol N, Watano K, Mishima T, Iwabuchi C, Kato K, Tanaka S, Bezbradica JS, Nakayama T, Tanigchi M, Miyake S, Yamamura T, Kitabatake A, Joyce S, Van Kaer L, Onoe K:Natural killer T cells accelerate atherogenesis in mice. Blood 104:2051-2059, 2004 |
| 31) | Satoh J-i, Nakanishi M, Koike F, Miyake S, Yamamuto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T:Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. Neurobiol Dis 18:537-550, 2005 |
| 32) | Ueno Y, Tanaka S, Sumii M, Miyake S, Tazuma S, Taniguchi M, Yamamura T, Chayama K:Single dose of OCH improves mucosal Th1/Th2 cytokine balance and prevents experimental colitis in the presence of Vα14 NKT cells in mice. Inflamm Bowel Disease 11:35-41, 2005 |
| 33) | Hashimoto D, Asakura S, Miyake S, Yamamura T, van Kaer L, Liu C, Tanimoto M, Teshima T:Stimulation of host natural killer T cells by synthetic glycolipid regulates acute graft-versus-host disease by inducint Th2 polarization of donor T cells. J Immunol 174:551-556, 2005 |
| 34) | Murata K, Toba T, Nakanishi K, Takahashi B, Yamamura T, Miyake S, Annoura H:Total synthesis of an immunosuppressive glycolipid, (2S,3S,4R)-1-O- (alpha-d- galactosyl)-2-tetracosanoylamino-1,3,4-nonanetriol. J Org Chem 70:2398-2401, 2005 |
| 35) | Yu KO, Im JS, Molano A, Dutronc Y, Illarionov PA, Forestier C, Fjiwara N, Arias I, Miyake S, Yamamur T, Chang YT, Besra GS, Porcellli SA:Modulation of CD1d-restricted NKT cell responses by using N-acylvariants of α-galactosylceramides. Proc Natl Acad Sci USA 102:3383-3388, 2005 |
| 36) | Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K:IFN-γ-mediated negative feedback regulation of NKT cell function by CD94/NKG2. Blood 106:184-192, 2005 |
| 37) | Chiba A, Kaieda S, Oki S, Yamamura T, Miyake S:The involvement of Vα14 NKT cells in the pathogenesis of murine models of arthritis. Arthritis Rheum 52:1941-1948, 2005 |
| 38) | Toba T, Murata K, Yamamura T, Miyake S, Annoura H:A concise synthesis of (3S,4S,5R)-1-(α-D-galactopyranosyl)-3-tetracosanoylamino-4,5-decanediol, α C-glycoside analogue of immunomodulating α-galactosylceramide OCH. Tetrahedron Letters 46:5043-5047, 2005 |
| 39) | Ronet C, Darche S, de Moraes ML, Miyake S, Yamamura T, Louis JA, Kasper LH, Buzoni-Gatel D:NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii. J Immunol 175: 899-908, 2005 |
| 40) | Oki S, Tomi C, Yamamura T, Miyake S:Preferential Th2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production inflammatory cytokines by bystander cells in vivo. Int Immunol 17:1619-1629, 2005 |
| 41) | Pyz E, Naidenko O, Miyake S, Yamamura T, Berberich I, Cardell S, Kronenberg M, Herrmann T:The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR. J Immunol 176:7447-7455, 2006 |
| 42) | Miyamoto K, Miyake S, Mizuno M, Oka N, Kusunoki S, Yamamura T:Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2 independent pathway. Brain 129:1984-1992, 2006 |
| 43) | Croxford JL, Miyake S, Huang Y-Y, Shimamura M, Yamamura T:Invariant Vα19i T cells regulate autoimmune inflammation. Nat Immunol 7:987-994, 2006 |
| 44) | Aranami T, Miyake S, Yamamura T:Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis. J Immunol 177:5659-5667, 2006 |
| 45) | Satoh J, Nakanishi M, Koike F, Onoue H, Aranami T, Ymamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Saito T, Ohta M, Miyake S, Kanda T, Fukazawa T, Yamamua T:T cell gene expression profiling identifies distinct subgroupus of Japanese multiple sclerosis patients. J Neuroimmunol 174:108-118, 2006 |
| 46) | Toba T, Murata K, Nakanishi K, Takahashi B, Takemoto N, Akabane M, Nakatsuka T, Imajo S, Yamamura T, Miyake S and Annoura H:Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs. Bioorganic Med Chem Let 17:2781-2784, 2007 |
| 47) | Kaieda S, Tomi C, Oki S, Yamamura T, Miyake S:Activation of iNKT cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis. Arthritis Rheum 56:1836-1845, 2007 |
| 48) | Sakuishi K, Oki S, Araki M, Porcelli SA, Miyake S, Yamamura T:Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation. J Immunol 179:3452-3462, 2007 |
| 49) | Ambrosino E, Terabe M, Halder RC, Peng J, Takaku S, Miyake S, Yamamura T, Kumar V, Berzofskky:Cross-regulation between Type I and Type II NKT cells in regulating turmor immunity: A new immunoregulatory axis. J Immunol 179:5126-5136, 2007 |
| 50) | Dondji B, Deak E, Goldsmith-Pestana K, Perez-Jimenez E, Esteban M, Miyake S, Yammaura T, McMahon-Pratt D:Intradermal NKT cell activation during DNA priming in heterologous prime-boost vaccination enhances T cell responses and protection against Leishmania. Eur J Immunol 38:706-19, 2008 |
| 51) | Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T:Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc Natl Acad Sci USA 105:8381-8386, 2008 |
| 52) | Sekine C, Sugihara T, Miyake S, Hirai H, Yoshida M, Miyasaka N, Kohsaka H. Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors. J Immunol 180:1954-1961, 2008 |
| 53) | Yokote H, Miyake S, Croxford JL, Oki S, Mizusawa H, Yamamura T. NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Ame J Patho 173:1714-23, 2008 |
| 54) | Theil MM, Miyake S, Mizuno M, Tomi C, Croxford J, Hosoda H, Theil J, von Horsten S, Yokote H, Chiba A, Lin Y, Oki S, Akamizu T, Kanagawa K, Yamamura T:Suppression of experimental autoimmune encephalomyelitis by Ghrelin. J Immunol 83(4):2859-66, 2009 |
| 55) | Fujia M, Otsuka T, Mizuno M, Tomi C, Yamamura T Miyake S. Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via iNKT cell-dependent mechanism. Ame J Patho 175(3):1116-23, 2009 |
| 56) | Noto D, Takahashi K, Miyake S, Yamada M. In vitro differentiation of lineage-negative bone marrow cells into microglia-like cells. Eur.J.Neuroscience, 31:1155-63, 2010 |
| 57) | Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S,Okamoto T, Ogawa M, Toda T, Yamamura T. Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc Natl Acad Sci USA 108(9):3701-3706, 2011 |
| 58) | Miyazaki Y, Miyake S, Chiba A, Lantz O, Yamamura T : Mucosal-associated invariant T cells regulate T helper type 1 response in multiple sclerosis. Int. Immunol. Advance Access published June 28, 2011 |