2024
- Takewaki D, Kiguchi Y, Masuoka H, Manu M, Raveney BJE, Narushima S, Kurokawa R, Ogata Y, Kimura Y, Sato N, Ozawa Y, Yagishita S, Araki T, Miyake S, Sato W, Suda W, Yamamura T..
Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis .
Cell Reports 43: 114785, 2024.
- Ho WJ, Marinova MB, Listijono DR, Bertoldo MJ, Richani D, Kim LJ, Brown A, Riepsamen AH, Cabot S, Frost ER, Bustamante S, Zhong L, Selesniemi K, Wong D, Madawala R, Marchante M, Goss DM, Li C, Araki T, Livingston DJ, Turner N, Sinclair DA, Walters KA, Homer HA, Gilchrist RB, Wu LE..
Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome.
EMBO Mol Med 16: 2583 - 2618, 2024.
- Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R, Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato DX, Inoue YU, Inoue T, KomineY, Yamamori T, Sakimura K, Miyakawa T.
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
eLife 12, RP89376, 2024.
2023
- Zhang S, Ohkawara B, Ito M, Huang Z, Zhao F, Nakata T, Takeuchi T, Sakurai H, Komaki H, Kamon M, Araki T, Ohno K.
A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells.
Hum Mol Genet 32: 1511–1523, 2023.
2022
- Nakazawa E, Fukushi T, Tachibana K, Uehara R, Arie F, Akter N, Maruyama M, Morita K, Araki T, Sadato N.
The way forward for neuroethics in Japan: A review of five topics surrounding present challenges.
Neuroscience Research,183:7-16, 2022.
- Hashimoto Y, Kuniishi H, Sakai K, Fukushima Y, Du X , Yamashiro K, Hori K, Imamura M, Hoshino M, Yamada M, Araki T, Itaka K, Sakagami H, Takeda S, Itaka K, Ichinohe N, Muntoni F, Sekiguchi M, Aoki Y.
Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy.
Progress in Neurobiology 216: 102288, 2022.
- Nakamori M, Shimizu H, Ogawa K, Hasuike Y, Nakajima T, Sakurai H, Araki T, Okada Y, Kakita A, Mochizuki H.
Cell type-specific abnormalities of central nervous system in myotonic dystrophy type 1.
Brain Communications 4(3):fcac154, 2022.
2021
- Koike S, Tanaka SC, Okada T, Aso T, Yamashita A, Yamashita O, Asano M, Maikusa N, Morita K, Okada N, Fukunaga M, Uematsu A, Togo H, Miyazaki A, Murata K, Urushibata Y, Autio J, Ose T, Yoshimoto J, Araki T, Glasser MF, Van Essen DC, Maruyama M, Sadato N, Kawato M, Kasai K, Okamoto Y, Hanakawa T, Hayashi T; Brain/MINDS Beyond Human Brain MRI Group.
Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan
NeuroImage: Clinical 8:102600, 2021.
- Uezumi A, Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Nakatani M, Hitachi K, Yamaguchi H, Wakatsuki S, Araki T, Morita M, Yamada H, Toyoda M, Kanazawa N, Nakazawa N, Hino J, Fukada S, Tsuchida K.
Mesenchymally expressed Bmp3b maintains skeletal muscle integrity and reduction of its expression contributes to sarcopenia.
Journal of Clinical Investigation. 131(1) e139617, 2021.
2020
- Nagano S, Jinno J, Abdelhamid RF, Jin Y, Shibata M, Watanabe S, Hirokawa S, Nishizawa M, Sakimura K, Onodera O, Okada H, Okada T, Saito Y, Takahashi-Fujigasaki J, Murayama S, Wakatsuki S, Mochizuki H, Araki T.
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons.
Acta Neuropathologica. 140(5):695-713, 2020.
- Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE.
NAD+ repletion rescues female fertility during reproductive aging.
Cell Reports. Volume 30, February 2020, Pages 1670-1681
- Huang K, Masuda A, Chen G, Bushra S, Kamon M, Araki T, Kinoshita M, Ohkawara B, Ito M, Ohno K.
Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells.
Scientific Reports. Volume 10, February 2020, Pages 2558
2019
- Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
Neuroscience Research Volume 139, February 2019, Pages 63-68
- Takahashi Y, Uchino A, Shioya A, Sano T, Matsumoto C, Numata-Uematsu Y, Nagano S, Araki T, Murata M, Murayama S, Saito Y.
Altered immunoreactivity of ErbB4, a causative gene product for ALS19.
Neuropathology 39: 268-278, 2019.
- Tsubota M, Fukuda R, Hayashi Y, Miyazaki T, Ueda S, Yamashita R, Koike N, Sekiguchi F, Wake H, Wakatsuki S, Ujiie Y, Araki T, Nishibori M, Kawabata A.
Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants.
J Neuroinflammation 16(1):199, 2019.
- Toshiyuki Araki
Regulatory Mechanism of Peripheral Nerve Myelination by Glutamate-Induced Signaling.
Myelin Advances in Experimental Medicine and Biology No.1190 pp 23-31, November, 2019.
2018
- Toshiyuki Araki, Masayoshi Kamon, Hidetoshi Sakurai
「Disease Modeling and Drug Development with DM1 Patient-Derived iPS Cells」
「Myotonic Dystrophy～Disease Mechanism, Current Management and Therapeutic Development」 pp 189-201. Ed by Masanori Takahashi, Tsuyoshi Matsumura. Springer, 2018
2017
- Imai S, Koyanagi M, Azimi Z, Nakazato Y, Matsumoto M, Ogihara T, Yonezawa A, Omura T, Nakagawa S, Wakatsuki S, Araki T, Kaneko S, Matsubara K.
Taxanes and platinum derivatives impair Schwann cells prior to induction of neurotoxicity via distinct mechanisms.
Sci Rep 7: 5947 (2017)
- Ueki J, Nakamori M, Nakamura M, Nishikawa M, YoshidaY, Tanaka A, Morizane A, Kamon M, Araki T, Takahash MP, Watanabe A, Inagaki N,Sakurai H.
Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability.
Sci Rep 7: 42522 (2017)
2016
- Takahashi Y, Kanai M, Taminato T, Watanabe S, Matsumoto C, Araki T, Okamoto T, Ogawa M, Murata M.
Compound heterozygous intermediate MJD alleles cause cerebellar ataxia with sensory neuropathy.
Neurol Genet. 3(1): e123 (2016)
- Saito F, Wakatsuki S, Tokunaga S, Araki T.
Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation.
Sci. Rep. 6,: 29856 (2016)
- Wakatsuki S, Araki T.
NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant.
Communicative & Integrative Biology 9(2) e1143575 (2016)
- Araki,T, Wakatsuki S.
ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration
Atlas of Science. January 11, 2016.
- Nagano S, Araki T
A cysteine residue is a key commander of SOD1-related neuronal toxicity in ALS.
Atlas of Science. February 4, 2016
- Seiichi Nagano, Toshiyuki Araki「Role of Cysteine Residue of Mutant Cu, Zn-superoxide Dismutase (SOD1) in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)」
「Novel Aspects of Amyotrophic Lateral Sclerosis」 page 87-100
Humberto Foyaca Sibat；Lurdes de Fatima Ibanez Valdes Eds;「Update on Amyotrophic Lateral Sclerosis」INTECH（Croatia）2016
ISBN 978-953-51-2601-0
2015
- Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T.
A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice - Relevance to the pathogenesis of ALS.
Hum Molec Genet 24(12):3427-39 (2015)
- Wakatsuki S, Furuno A, Ohshima M, Araki T.
Oxidative stress-dependent phosphorylation activates ZNRF1 ubiquitin ligase to induce neuronal apoptosis and Wallerian degeneration.
J Cell Biol. 211(4) 881-896 (2015)
- Shuji Wakatsuki, Toshiyuki Araki
「Significance of Mechanism-Oriented Research Toward Neuronal Protection Therapy Against Neurodegenerative Disorders ~ ZNRF1 E3 Ubiquitin Ligase as a Critical Mediator for Wallerian Degeneration and Neuronal Apoptosis」
「Neurodegenerative Disorders as Systemic Diseases 」 pp 159-182. Ed by Keiji Wada Springer, 2015
2014
- Oie S, Matsuzaki K, Yokoyama W, Tokunaga, S, Waku T, Han SI, Iwasaki N, Mikogai A, Yasuzawa-Tanaka K, Hiyoshi H, Nakajima Y, Araki T, Kimura K, Yanagisawa J, Murayama A.
Hepatic rRNA Transcription Regulates High-Fat Diet-Induced Obesity.
Cell Reports 7(3): 807–820 (2014)
- Wakatsuki S, Araki T, Sehara A.
Neuregulin-1/Glial Growth Factor stimulates Schwann Cell Migration by inducing the alpha5beta1 integrin–ErbB2–Focal Adhesion Kinase Complex Formation.
Genes Cell 19(1):66-77 (2014)
2013
- Togashi K, Wakatsuki S, Furuno A, Tokunaga S, Nagai Y, Araki, T.
Na+/H+ exchangers induce autophagy in neurons and inhibit polyglutamine-induced
aggregate formation.
PLoS One 8(11):e81313 (2013)
- Park JY, Jang SY, Shin YK, Koh H, Suh DJ, Tokunaga S, Araki T, Park HT.
Mitochondrial swelling and microtubule depolymerization are associated with energy depletion in axon degeneration.
Neuroscience. 238:258-269 (2013)
2012
2011
2010
- Higashi S, Tsuchiya Y, Araki T, Wada K, Kabuta T.
TDP-43 physically interacts with Amyotrophic Lateral Sclerosis-Linked mutant Cu/Zn superoxide dismutase.
Neurochem International. 57:906-913(2010)
- Mitsuhashi H, Hayashi YK, Matsuda C, Noguchi S, Wakatsuki S, Araki T, Nishino I.
Specific phosphorylation on Ser458 of A-type lamins in LMNA-associated myopathy patients.
J Cell Sci. 123:3893-3900(2010)
- Saitoh F, Araki T.
Proteasomal degradation of glutamine synthetase regulates
schwann cell differentiation.
J Neurosci. 30:1204-1212(2010)
2009
- Takada H, Kawana T, Ito Y, Kikuno RF, Mamada H, Araki T,
Koga H, Asashima M, Taira M.
The RNA binding protein Mex3b has a fine-tuning system for mRNA regulation in early Xenopus development.
Development 136:2413-2422, 2009
- Yahata N, Yuasa S, Araki T.
NMNAT expression in mitochondrial matrix delays Wallerian degeneration.
J. Neurosci. 29: 6276-6284, 2009
- Wakatsuki S, Yumoto N, Komatsu K, Araki T, Sehara A.
Roles of meltrin beta/ADAM19 in progression of Schwann cell differentiation and myelination during sciatic nerve regeneration.
J. Biol.Chem. 284: 2957-2966, 2009
- Tateno M, Kato S, Sakurai T, Nukina N, Takahashi R, Araki T.
Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3.
Hum Mol Genet 18: 942-955, 2009
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