Staff Researcher Seiichi Nagano, MD PhD

個人写真

Publication list before 2010

  • Kishigami H, Nagano S, Bush AI, Sakoda S.
    Monomerized Cu, Zn-superoxide dismutase induces oxidative stress through aberrant Cu affinity.
    Free Radic Biol Med 48, 945-952, 2010.

  • Nagano S, Bush AI. Sensitive, selective and irreversible inhibition of cyclooxygenase-2 activity by copper. ChemMedChem 3, 223-225, 2008.

  • Watanabe S, Nagano S, Duce J, Kiaei M, Li QX, Tucker SM, Tiwari A, Brown RHJ, Beal MF, Hayward LJ, Culotta VC, Yoshihara S, Sakoda S, Bush AI. Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
    Free Radic Biol Med 42, 1534-1542, 2007.

  • Sumi H, Nagano S, Fujimura H, Kato S, Sakoda S. Inverse correlation between the formation of mitochondria-derived vacuoles and Lewy-body-like hyaline inclusions in G93A superoxide-dismutase-transgenic mice.
    Acta Neuropathol 112, 52-63, 2006.

  • Yamamoto Y, Nakamori M, Konaka K, Nagano S, Shimazaki H, Takiyama Y, Sakoda S. Sacsin-related ataxia caused by the novel nonsense mutation Arg4325X.
    J Neurol 253, 1372-1373, 2006.

  • Ouyang Y, Takiyama Y, Sakoe K, Shimazaki H, Ogawa T, Nagano S, Yamamoto Y, Nakano I. Sacsin-related ataxia (ARSACS): expanding the genotype upstream from the gigantic exon.
    Neurology 66, 1103-1104, 2006.

  • Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, Shawlot W, Hayashizaki Y, Westphal H, Behringer RR, Matsuda Y, Sakoda S, Kondoh H, Sasaki H. Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.
    Development 132, 2535-2546, 2005.

  • Puglielli L, Friedlich AL, Setchell KDR, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Cholesterol oxidase mimetic activity of Alzheimer's disease beta-amyloid.
    J Clin Invest 115, 2556-2563, 2005.

  • Yamamoto Y, Hiraoka K, Araki M, Nagano S, Shimazaki H, Takiyama Y, Sakoda S. Novel compound heterozygous mutations in sacsin-related ataxia.
    J Neurol Sci 239, 101-104, 2005.

  • Sato T, Nakanishi T, Yamamoto Y, Andersen PM, Ogawa Y, Fukada K, Zhou Z, Aoike F, Sugai F, Nagano S, Hirata S, Ogawa M, Nakano R, Ohi T, Kato T, Nakagawa M, Hamasaki T, Shimizu A, Sakoda S. Rapid disease progression correlates with instability of mutant SOD1 in familial ALS.
    Neurology 65, 1954-1957, 2005.

  • Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.
    J Biol Chem 279, 14673-14678, 2004.

  • Sato T, Yamamoto Y, Nakanishi T, Fukada K, Sugai F, Zhou Z, Okuno T, Nagano S, Hirata S, Shimizu A, Sakoda S. Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses.
    J Neurol Sci 218, 79-83, 2004.

  • Nagano S, Fujii Y, Yamamoto T, Taniyama M, Fukada K, Yanagihara T, Sakoda S. The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice.
    Exp Neurol 179, 176-180, 2003.

  • Nagano S, Satoh M, Sumi H, Fujimura H, Tohyama C, Yanagihara T, Sakoda S. Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner.
    Eur J Neurosci 13, 1363-1370, 2001.

  • Fukada K, Nagano S, Satoh M, Tohyama C, Nakanishi T, Shimizu A, Yanagihara T, Sakoda S. Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice.
    Eur J Neurosci 14, 2032-2036, 2001.

  • Nagano S, Ogawa Y, Yanagihara T, Sakoda S. Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice.
    Neurosci Lett 265, 159-162, 1999.

  • Yamamoto Y, Yoshikawa H, Nagano S, Kondoh G, Sadahiro S, Gotow T, Yanagihara T, Sakoda S. Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin.
    Eur J Neurosci 11, 847-855, 1999.