Intramural Research Grants for Neurological and Psychiatric Disorders of NCNP
Understanding the Pathophysiologies of Neuropsychiatric and Muscular Diseases by utilizing Genome-edited model animals
ABOUT US
How is the human brain structure elaborated to sophisticatedly execute its higher function?
This is one of the very central subjects in the field of molecular neurodevelopmental biology
and the outcomes from our research would help provide valuable indication
for the healthy growth as well as the pathology of our own brain.
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OUR RESEARCH
- ・Elucidation of developmental and/or evolutionary mechanisms of cortical arealization
- ・Clarification of cellular and molecular machinery for compartment boundary formation
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TECHNICAL
ADVANTAGES- ・Generation of transgenic mouse lines
- ・Mammalian whole embryo culture system
- ・CRISPR/Cas9 genome editing system
Publications
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2020
Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness.
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2016
Classic cadherin expressions balance postnatal neuronal positioning and dendrite dynamics to elaborate the specific cytoarchitecture of the mouse cortical area.
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2013
A sharp cadherin-6 gene expression boundary in the developing mouse cortical plate demarcates the future functional areal border.
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2019
クローニングフリーCRISPR/Cas9法によるノックインマウス作製術
CONTACT
先端技術や情報に囲まれた恵まれた環境で自由な発想のもと、新たな概念や方法論の創出に携わってみませんか？
さらなる詳細に興味がある方は、直接お問い合わせください。
042-341-2712
（内線 5278 または 5911）