独立行政法人 国立精神・神経医療研究センター 神経研究所
神経薬理研究部
Department of Molecular Pharmacology
研究業績
2010年
Kimura, Y., Goto, Y., and Kimura, H. Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxid. Red. Signal. 12, 1-13, 2010.
Namekata, K., Harada, C., Taya, C., Guo, X., Kimura, H., Parada, L.F., and Harada, T. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc. Natl. Acad. Sci. USA. 107, 7586-7591, 2010.
Takahashi M., Watanabe S., Murata M., Furuya H., Kanazawa I., Wada K., and Hohjoh H.: Tailor-made RNAi knockdown against triplet repeat disease-causing alleles. Proc Natl Acad Sci USA., 107: 21731-21736, 2010.
Ohnishi Y., Totoki Y., Toyoda A., Watanabe T., Yamamoto Y., Tokunaga K., Sakaki Y., Sasaki H., and Hohjoh H.: Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucl. Acids Res., 38: 5141-5151, 2010.
Hohjoh H.: Allele-specific silencing by RNA interference. In RNA interference. Methods Mol. Biol., 623: 67-79, 2010.
2009年
Ishigami, M., Hiraki, K., Umemura, K., Ogasawara, Y., Ishii, K. and Kimura, H. A source of hydrogen sulfide and a mechanism of its release in the brain. Antioxid. Red. Signal. 11, 205-214 2009.
Shibuya, N., Tanaka, M, Yoshida, M., Ogasawara, Y., Togawa, T., Ishii, K. and Kimura, H. 3-Mercaptopyyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid. Red. Signal.11, 703-714, 2009.
Kaneko, Y., Kimura, T., Taniguchi, S., Souma, M., Kojima Y., Kimura Y., Kimura, H. and Niki, I. Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose. FEBS Lett. 585, 377-382, 2009.
Takei, N., Miyashita, A., Tsukie, T., Arai, H., Asada, T., Imagawa, M., Shoji, M., Higuchi, S., Urakami, K., Kimura, H., Kakita, A., Takahashi, H., Tsuji, S., Kanazawa, I., Ihara, Y., Odani, S., Kuwano, R. and the Japanese Genetic Study Consortium for Alzheimer Disease. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics 93, 441-448, 2009.
Shibuya, N., Mikami, Y., Kimura, Y., Nagahara, N., and Kimura, H. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J. Biochem. 146, 623-626, 2009.
Eda A., Tamura Y., Yoshida M., and Hohjoh H.: Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell. BBRC, 388: 648-653, 2009.
Kitamura K., Itou Y., Yanazawa M., Ohsawa M., Suzuki-Migishima R., Umeki Y., Hohjoh H., Yanagawa Y., Shinba T., Itoh M., Nakamura K., and Goto Y.: Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice. Hum. Mol. Genet., 18: 3708-3724, 2009.
Hohjoh H., Akari H., Fujiwara Y., Tamura Y., Hirai H., and Wada K.: Molecular cloning and characterization of the common marmoset huntingtin gene. Gene, 432: 60-66, 2009.
Tamura Y., Yoshida M., Ohnishi Y., and Hohjoh H.: Variation of gene silencing involving endogenous microRNA in mammalian cells. Mol Biol Rep, 36: 1413-1420, 2009.
2008年
Tamura Y., Yoshida M., Ohnishi Y., and Hohjoh H.: Variation of gene silencing involving endogenous microRNA in mammalian cells. Mol Biol Rep, 2008 Aug 12. [Epub ahead of print].
Doi Y., Oki S., Ozawa T., Hohjoh H., Miyake S., and Yamamura T.: Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc Natl Acad Sci USA., 105: 8381-8386, 2008.
Ohnishi Y., Tamura Y., Yoshida M., Tokunaga K., and Hohjoh H.: Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi. PLoS ONE 3(5): e2248, 2008.
2007年
Elrod, JW., Calvert, JW., Morrison, J., Doeller, JE, Kraus, DW., Tao, L., Jiao, X., Scalia, R., Kiss, L., Szabo, C., Kimura, H., Chow, CW., Lefer, DJ. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc. Natl. Acad. Sci. USA. 104, 11560-11565, 2007. PMID:17878306
Tsugane, M., Nagai, Y., Kimura, Y., Oka, J. and Kimura, H. Differentiated astrocytes acquire sensitivity to hydrogen sulfide that is diminished by the transformation into reactive astrocytes. Antioxidants & Red. Signal. 9, 257-269, 2007. PMID:17115938
Umemura, K. and Kimura, H. Hydrogen sulfide enhances reducing activity in neurons: Neurotrophic role of H2S in the brain? Antioxid. Redox Signal. 9, 2035-2042, 2007. PMID:17822366
Saito, Y., Katori, N., Soyama, A., Nakajima, Y., Yoshitani, T., Kim, S-R., Fukashima-Uesaka, H., Kurose, K., Kaniwa, N., Ozawa, S., Kamatani, N., Komamura, K., Kamakura, S., Kitakaze, M., Tomoike, H., Sugai, K., Minami, N., Kimura, H., Goto, Y. Minami, H., Yshida, T., Kunitoh, H., Ohe, Y., Yamamoto, N., Tamura, T., Saijo, N and Sawada, J. CYP2C8 haplotype structures and their influence onpharmacokinetics of paclitaxel in a Japanese population. Pharmacogenetics & Genomics 17, 461-471, 2007. PMID:17558302
Hohjoh H, Fukushima T: Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. BBRC 362: 360-367, 2007
Tamura Y, Kunugi H, Ohashi J, Hohjoh H: Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry 12: 593-600, 2007
Tamura Y, Kunugi H, Ohashi J, Hohjoh H: The possible association between epigenetic aberration in DNA methylation in RELN and psychiatric disorders. Mol Psychiatry 12: 519, 2007
Hohjoh H, Fukushima T: Expression profile analysis of microRNA (miRNA) in mouse central nervous system using a new miRNA detection system that examines hybridization signals at every step of washing. Gene 391: 39-44, 2007
2006年
Umemura, K., Yamashita, N., Yu, X., Arima, K., Asada, T., Makifuchi, T., Murayama, S., Saito, Y., Kanamaru, K., Goto, Y., Kohsaka, S., Kanazawa, I., Kimura, H. Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients. Neurosci. Lett. 400, 97-100, 2006.
Kimura, Y. Dargusch, R. Schubert, D. and Kimura, H. Hydrogen Sulfide Protects HT22 Neuronal Cells from Oxidative Stress. Antiox. & Red. Signal. 8, 661-670, 2006.
Kaneko, Y., Kimura, Y., Kimura, H. and Niki, I. L-cysteine inhibits insulin release from the pancreatic ?-cell. Possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes 55, 1391-1397, 2006.
Schicho, R., Krueger, D., Zeller, F., Weyhern, C.W.H.V, Frieling, T., Kimura, H., Ishii, I., Giorgio, R.D., Campi, B. and Schemann, M. Hydrogen sulfide is a novel prosecretory neuromodulator in the guineapig and human colon. Gastroenterology 131, 1542-1552, 2006.
Ohashi J., Naka I., Toyoda A., Takasu M., Tokunaga K., Ishida T., Sakaki Y., and Hohjoh H. (2006) Estimation of the species-specific mutation rates of the DRB1 locus in human and chimpanzee. Tissue Antigens, 68: 427-431.
Sakai T. and Hohjoh H. (2006) Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference. Cell Biol Int, 30: 952-956.
Kawashima M., Tamiya G., Oka A., Hohjoh H., Juli T., Ebisawa T., Honda Y., Inoko H., and Tokunaga K. (2006) Genome-wide association analysis of human narcolepsy and a new resistance gene. Am J Hum Genet, 79: 252-263.
Ohnishi Y., Tokunaga K., Kaneko K., and Hohjoh H. (2006) Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles. J. RNAi Gene silencing, 2: 154-160
Kimura, Y., Goto, Y., and Kimura, H. Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria. Antioxid. Red. Signal. 12, 1-13, 2010.
Namekata, K., Harada, C., Taya, C., Guo, X., Kimura, H., Parada, L.F., and Harada, T. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc. Natl. Acad. Sci. USA. 107, 7586-7591, 2010.
Takahashi M., Watanabe S., Murata M., Furuya H., Kanazawa I., Wada K., and Hohjoh H.: Tailor-made RNAi knockdown against triplet repeat disease-causing alleles. Proc Natl Acad Sci USA., 107: 21731-21736, 2010.
Ohnishi Y., Totoki Y., Toyoda A., Watanabe T., Yamamoto Y., Tokunaga K., Sakaki Y., Sasaki H., and Hohjoh H.: Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucl. Acids Res., 38: 5141-5151, 2010.
Hohjoh H.: Allele-specific silencing by RNA interference. In RNA interference. Methods Mol. Biol., 623: 67-79, 2010.
2009年
Ishigami, M., Hiraki, K., Umemura, K., Ogasawara, Y., Ishii, K. and Kimura, H. A source of hydrogen sulfide and a mechanism of its release in the brain. Antioxid. Red. Signal. 11, 205-214 2009.
Shibuya, N., Tanaka, M, Yoshida, M., Ogasawara, Y., Togawa, T., Ishii, K. and Kimura, H. 3-Mercaptopyyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid. Red. Signal.11, 703-714, 2009.
Kaneko, Y., Kimura, T., Taniguchi, S., Souma, M., Kojima Y., Kimura Y., Kimura, H. and Niki, I. Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose. FEBS Lett. 585, 377-382, 2009.
Takei, N., Miyashita, A., Tsukie, T., Arai, H., Asada, T., Imagawa, M., Shoji, M., Higuchi, S., Urakami, K., Kimura, H., Kakita, A., Takahashi, H., Tsuji, S., Kanazawa, I., Ihara, Y., Odani, S., Kuwano, R. and the Japanese Genetic Study Consortium for Alzheimer Disease. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics 93, 441-448, 2009.
Shibuya, N., Mikami, Y., Kimura, Y., Nagahara, N., and Kimura, H. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J. Biochem. 146, 623-626, 2009.
Eda A., Tamura Y., Yoshida M., and Hohjoh H.: Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell. BBRC, 388: 648-653, 2009.
Kitamura K., Itou Y., Yanazawa M., Ohsawa M., Suzuki-Migishima R., Umeki Y., Hohjoh H., Yanagawa Y., Shinba T., Itoh M., Nakamura K., and Goto Y.: Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice. Hum. Mol. Genet., 18: 3708-3724, 2009.
Hohjoh H., Akari H., Fujiwara Y., Tamura Y., Hirai H., and Wada K.: Molecular cloning and characterization of the common marmoset huntingtin gene. Gene, 432: 60-66, 2009.
Tamura Y., Yoshida M., Ohnishi Y., and Hohjoh H.: Variation of gene silencing involving endogenous microRNA in mammalian cells. Mol Biol Rep, 36: 1413-1420, 2009.
2008年
Tamura Y., Yoshida M., Ohnishi Y., and Hohjoh H.: Variation of gene silencing involving endogenous microRNA in mammalian cells. Mol Biol Rep, 2008 Aug 12. [Epub ahead of print].
Doi Y., Oki S., Ozawa T., Hohjoh H., Miyake S., and Yamamura T.: Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc Natl Acad Sci USA., 105: 8381-8386, 2008.
Ohnishi Y., Tamura Y., Yoshida M., Tokunaga K., and Hohjoh H.: Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi. PLoS ONE 3(5): e2248, 2008.
2007年
Elrod, JW., Calvert, JW., Morrison, J., Doeller, JE, Kraus, DW., Tao, L., Jiao, X., Scalia, R., Kiss, L., Szabo, C., Kimura, H., Chow, CW., Lefer, DJ. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc. Natl. Acad. Sci. USA. 104, 11560-11565, 2007. PMID:17878306
Tsugane, M., Nagai, Y., Kimura, Y., Oka, J. and Kimura, H. Differentiated astrocytes acquire sensitivity to hydrogen sulfide that is diminished by the transformation into reactive astrocytes. Antioxidants & Red. Signal. 9, 257-269, 2007. PMID:17115938
Umemura, K. and Kimura, H. Hydrogen sulfide enhances reducing activity in neurons: Neurotrophic role of H2S in the brain? Antioxid. Redox Signal. 9, 2035-2042, 2007. PMID:17822366
Saito, Y., Katori, N., Soyama, A., Nakajima, Y., Yoshitani, T., Kim, S-R., Fukashima-Uesaka, H., Kurose, K., Kaniwa, N., Ozawa, S., Kamatani, N., Komamura, K., Kamakura, S., Kitakaze, M., Tomoike, H., Sugai, K., Minami, N., Kimura, H., Goto, Y. Minami, H., Yshida, T., Kunitoh, H., Ohe, Y., Yamamoto, N., Tamura, T., Saijo, N and Sawada, J. CYP2C8 haplotype structures and their influence onpharmacokinetics of paclitaxel in a Japanese population. Pharmacogenetics & Genomics 17, 461-471, 2007. PMID:17558302
Hohjoh H, Fukushima T: Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. BBRC 362: 360-367, 2007
Tamura Y, Kunugi H, Ohashi J, Hohjoh H: Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry 12: 593-600, 2007
Tamura Y, Kunugi H, Ohashi J, Hohjoh H: The possible association between epigenetic aberration in DNA methylation in RELN and psychiatric disorders. Mol Psychiatry 12: 519, 2007
Hohjoh H, Fukushima T: Expression profile analysis of microRNA (miRNA) in mouse central nervous system using a new miRNA detection system that examines hybridization signals at every step of washing. Gene 391: 39-44, 2007
2006年
Umemura, K., Yamashita, N., Yu, X., Arima, K., Asada, T., Makifuchi, T., Murayama, S., Saito, Y., Kanamaru, K., Goto, Y., Kohsaka, S., Kanazawa, I., Kimura, H. Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients. Neurosci. Lett. 400, 97-100, 2006.
Kimura, Y. Dargusch, R. Schubert, D. and Kimura, H. Hydrogen Sulfide Protects HT22 Neuronal Cells from Oxidative Stress. Antiox. & Red. Signal. 8, 661-670, 2006.
Kaneko, Y., Kimura, Y., Kimura, H. and Niki, I. L-cysteine inhibits insulin release from the pancreatic ?-cell. Possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes 55, 1391-1397, 2006.
Schicho, R., Krueger, D., Zeller, F., Weyhern, C.W.H.V, Frieling, T., Kimura, H., Ishii, I., Giorgio, R.D., Campi, B. and Schemann, M. Hydrogen sulfide is a novel prosecretory neuromodulator in the guineapig and human colon. Gastroenterology 131, 1542-1552, 2006.
Ohashi J., Naka I., Toyoda A., Takasu M., Tokunaga K., Ishida T., Sakaki Y., and Hohjoh H. (2006) Estimation of the species-specific mutation rates of the DRB1 locus in human and chimpanzee. Tissue Antigens, 68: 427-431.
Sakai T. and Hohjoh H. (2006) Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference. Cell Biol Int, 30: 952-956.
Kawashima M., Tamiya G., Oka A., Hohjoh H., Juli T., Ebisawa T., Honda Y., Inoko H., and Tokunaga K. (2006) Genome-wide association analysis of human narcolepsy and a new resistance gene. Am J Hum Genet, 79: 252-263.
Ohnishi Y., Tokunaga K., Kaneko K., and Hohjoh H. (2006) Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles. J. RNAi Gene silencing, 2: 154-160
