部長 荒木 敏之

末梢神経の特徴である神経再生を可能にするSchwann細胞の因子に関する研究をスタートに、ミエリン化の制御機構、さらには神経軸索の変性過程におけるユビキチン化反応の役割、NAD合成反応系とNADを基質とするSir2の軸索保護における役割、さらに神経細胞の代謝と神経保護メカニズムと、実験結果に導かれて徐々に興味の対象を広げてきました。 今は、いろんな分野からやってきてくれた研究員と一緒に研究できることを嬉しく思っています。

学歴

1989年 大阪大学医学部卒業 医師免許取得
1994年 大阪大学大学院医学研究科生理系修了 医学博士

職歴

1990年 大阪大学医学部附属病院 非常勤医員(研修医・第一内科)
1996年〜1997年 大阪大学医学部 助手
1993年〜1996年 Postdoctoral research fellow, Washington University School of Medicine
1997年〜1998年  Research associate, Washington University School of Medicine
1998年〜2005年  Assistant professor, Washington University School of Medicine

2005年2月より国立精神・神経センター (2010年4月より独立行政法人 国立精神・神経医療研究センター、2015年4月より国立研究開発法人 国立精神・神経医療研究センター)
神経研究所 疾病研究第5部長(現職)
早稲田大学 先進理工学部 客員教授(現職)
2014年4月より東京農工大学 工学部 生命工学科 客員教授(現職)

着任前の実績

  • Araki T, Yamano M, Murakami T, Wanaka A, Betz H, and Tohyama M: Localization of Glycine Receptors in the Rat Central Nervous System: An Immunocytochemical Analysis Using Monoclonal Antibody. Neurosci. 1988;25: 613-624
  • Murakami T, Araki T, Yamano M, Wanaka A, Betz H, and Tohyama M: Localization of the Glycine Receptors in the Rat Central Nervous System: An Immunocytochemical Analysis. Adv Exp Med Biol. 1988;236:71-80
  • Tohyama M, Wanaka A, Araki T, Betz H, and Malbon CC: Localization of Glycine and Beta-Adrenagic Receptors in the Rat Brain. Arch. Histol. Cytol. 1989;52:39-48.
  • Zhang JH, Araki T, Sato M, and Tohyama M: Distribution of the GABAA Receptor 1 Subunit Gene Expression in the Rat Forbrain. Mol. Brain. Res. 1991;11:239-247.
  • Araki T, Sato M, Zhang J, Manabe Y, and Tohyama M. Localization of GABAA-Receptor 2 Subunit mRNA-containing Neurons in the Rat Central Nervous System. Neurosci. 1992;47:45-61.
  • Araki T, and Tohyama M: Region-specific expression of the mRNAs encoding 3 and 4 subunits of GABAA receptor in the rat brain. Mol. Brain Res. 1992;12:293-314.
  • Furuyama T, Sato M, Sato K, Araki T, Inagaki S, Takagi H, and Tohyama M: Coexpression of glycine receptor subunit and GABAA receptor subunit mRNA in the rat dorsal root anglion cells. Mol. Brain Res. 1992;12:335-338.
  • Araki T, Kiyama H, and Tohyama M: The GABAA receptor 1 subunit is expressed by distinct neuronal populations. Mol. Brain Res. 1992;15:121-132
  • Zhang JH, Sato M, Araki T, and Tohyama M: Postnatal ontogenesis of neurons containing GABAA 1 subunit mRNA in the rat forebrain. Mol. Brain Res. 1992;16: 193-203.
  • Araki T, Kiyama H, Tohyama M: GABAA receptor subunits show differential expression during cortical development in the rat brain. Neurosci. 1992;51:583-591.
  • Yoshimura R, Kiyama H, Kimura T, Araki T, Maeno H, Tanizawa O, and Tohyama M: Distribution of oxytocin receptor mRNA in the rat CNS. Endocrinology 1993;133:1239-46.
  • Araki T, Kenimer JG, Nishimune A, Sugiyama H, Yoshimura R, and Kiyama H: Identification of the metabotropic glutamate receptor-1 protein in the rat trigeminal ganglion. Brain Research 1993;627:341-344.
  • Araki T, Kiyama H, Maeno H, and Tohyama M, Differential immunocytochemical localization of GABAA receptor g1 and g2 subunits in the rat brain. Molecular Brain Research 1993;20:263-266.
  • Kitahara T, Takeda N, Ohno K, Araki T, Kubo T, and Kiyama H. Expression of GABAA receptor g1 and g2 subunits in the peripheral vestibular system of the rat. Brain Research. 1994;650:157-60.
  • Kondo E, Kiyama H, Araki T, Shida T, Ueda Y, and Tohyama M. Coexpression of GABAA receptor g1 and g2 subunits in the rat trigeminal ganglion. Molecular Brain Research 1994;21:363-367.
  • Shida T, Kondo E, Ueda Y, Takai N, Yoshida Y, Araki T, Kiyama H and Tohyama M. Role of amino acids in salivation and the localization of their receptors in the rat salivary gland. Mol. Brain Res. 1995;21:363-367
  • Araki T and Milbrandt J: Ninjurin, a Novel Adhesion Molecule, Is Induced by Nerve Injury and Promotes Axonal Growth. Neuron 1996;17:353-361.
  • Araki T, Zimonjic DB, Popescu NC, Milbrandt J: Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. J Biol Chem 1997;272:21373-21380.
  • Enomoto H., Araki T., Jackman A, Heuckeroth, RO, Snider, WD, Johnson EM Jr. and Milbrandt J. GFRa1 deficient mice have deficits in the enteric nervous system and kidneys. Neuron 1998;21:317-24.
  • Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM Jr, Milbrandt J. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron 1998;21:1291-302
  • Araki T, Milbrandt J. Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. J. Neurosci 2000; 20:187-195
  • Nagarajan R, Svaren J, Le N, Araki T, Watson M and Milbrandt J. Egr2 mutation in inherited neuropathies dominant negatively inhibit myelin structural gene expression. Neuron 2001; 30: 355-368.
  • Araki T. Nagarajan R. and Milbrandt J. Identification of genes induced after peripheral nerve injury: expression profiling and novel gene discovery. J. Biol. Chem. 2001;276:34131-34141
  • Magee, JA, Araki T, Patil S, Ehrig T, Humphrey PA, Catalona WJ, Watson MA, and Milbrandt J. Expression profiling reveals hepsin overexpression in prostate cancer. Cancer Res. 2001: 61: 5692-5696
    25. Nagarajan R, Le N, Mahoney H, Araki T, and Milbrandt J. Deciphering peripheral nerve myelination using Schwann cell expression profiling. PNAS 2002; 99: 8998-9003.
    26. Honma Y, Araki T, Gianino S, Bruce A, Heuckeroth RO, Johnson, EM Jr., Milbrandt J. Artemin is a Vascular-Derived Neurotropic Factor for Developing Sympathetic Neurons. Neuron 2002, 35: 267-282
    27. Araki T, Milbrandt J.ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. J. Neurosci. 2003, 23: 9385-9394.
  • Araki T, Sasaki Y, and Milbrandt J. Increased NAD Biosynthesis and SIRT1 Activation Prevents Axonal Degeneration. Science 2004, 305: 1010-1013
  • Toyama T, Sasaki Y, Horimoto M, Iyoda K, Yakushijin T, Ohkawa K, Takehara T, Kasahara A, Araki T, Hori M, Hayahsi N. Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells. J Hepatol 41:637-643, 2004.
  • Le N, Nagarajan R, Wang JY, Araki T, Schmidt RE, Milbrandt J.
    Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.
    PNAS 102(7):2596-601, 2005
  • Le N, Nagarajan R, Wang J, LaPash C, Araki T, Schmidt R, Milbrandt J. Nab proteins are essential for peripheral nervous system myelination . Nature Neurosci. 8: 932-940, 2005