研究実績

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2024年

原著論文

• Kamon M, Wakatsuki S, Nakamori M, Takahashi MP, Mori-Yoshimura M, Komaki H, Araki T.
  Identification of ZNF850 as a novel CTG repeat expansion-related gene in myotonic dystrophy type 1 patient-derived iPSCs
  Human Molecular Genetics in press.

• Takewaki D, Kiguchi Y, Masuoka H, Manu M, Raveney BJE, Narushima S, Kurokawa R, Ogata Y, Kimura Y, Sato N, Ozawa Y, Yagishita S, Araki T, Miyake S, Sato W, Suda W, Yamamura T..
  Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis .
  Cell Reports 43: 114785, 2024.

• Ho WJ, Marinova MB, Listijono DR, Bertoldo MJ, Richani D, Kim LJ, Brown A, Riepsamen AH, Cabot S, Frost ER, Bustamante S, Zhong L, Selesniemi K, Wong D, Madawala R, Marchante M, Goss DM, Li C, Araki T, Livingston DJ, Turner N, Sinclair DA, Walters KA, Homer HA, Gilchrist RB, Wu LE..
  Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome.
  EMBO Mol Med 16: 2583 - 2618, 2024.

• Nagayama T, Yagishita S, Shibata M, Furuno A, Saito T, Saido TC, Wakatsuki S, Araki T.
  Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation.
  Neuroscience Research 205:40-44, 2024.

• Yagishita S, Shibata M, Furuno A, Wakatsuki S, Araki T.
  Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules.
  Neurology International 16, 653-662, 2024.

• Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R, Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato DX, Inoue YU, Inoue T, KomineY, Yamamori T, Sakimura K, Miyakawa T.
  Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
  eLife 12, RP89376, 2024.

総説・著書

• 大野萌馨, 若月修二, 高尾啓三, 荒木敏之
  ユビキチン・プロテアソームシステム依存的タンパク質分解の破綻による神経疾患の発症機序の解明
  日本応用酵素協会誌 58: 1-8 2024年3月

2023年

原著論文

• Numata-Uematasu Y, Wakatsuki S, Kobayashi-Ujiie Y Sakai K, Ichinohe N, Araki T.
  In vitro myelination using explant culture of dorsal root ganglia: an efficient tool for analyzing peripheral nerve differentiation and disease modeling.
  PLOS One 10.1371/journal.pone.0285897, 2023.

• Zhang S, Ohkawara B, Ito M, Huang Z, Zhao F, Nakata T, Takeuchi T, Sakurai H, Komaki H, Kamon M, Araki T, Ohno K.
  A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells.
  Hum Mol Genet 32: 1511–1523, 2023.

• Wakatsuki S, Araki T.
  Novel insights into the mechanism of ROS-mediated neurodegeneration: selective phosphorylation of p47-phox serves as a priming signal of ROS-mediated neurite degeneration.
  Neural Regeneration Research　 18(4):746-749, 2023.

• Funakoshi M, Araki T.
  Mechanism of initiation and regulation of axonal degeneration with special reference to NMNATs and Sarm1.
  Neuroscience Research 197:3-8, 2023.

2022年

原著論文

• Das J, Forlini C, Porcello DM, Rommelfanger KS, Salles A, Global Neuroethics Summit Delegates.
  Neuroscience is ready for neuroethics engagement
  Frontiers in Communication. 7: 909964, 2022.

• Nakazawa E, Fukushi T, Tachibana K, Uehara R, Arie F, Akter N, Maruyama M, Morita K, Araki　T, Sadato N.
  The way forward for neuroethics in Japan: A review of five topics surrounding present challenges.
  Neuroscience Research,183:7-16, 2022.

• Hashimoto Y, Kuniishi H, Sakai K, Fukushima Y, Du X , Yamashiro K, Hori K, Imamura M, Hoshino M, Yamada M, Araki T, Itaka K, Sakagami H, Takeda S, Itaka K, Ichinohe N, Muntoni F, Sekiguchi M, Aoki Y.
  Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy.
  Progress in Neurobiology 216: 102288, 2022.

• Nakamori M, Shimizu H, Ogawa K, Hasuike Y, Nakajima T, Sakurai H, Araki T, Okada Y, Kakita A, Mochizuki H.
  Cell type-specific abnormalities of central nervous system in myotonic dystrophy type 1.
  Brain Communications 4(3):fcac154, 2022.

• Wakatsuki S, Takahashi Y, Shibata M, Araki T.
  Selective phosphorylation of serine 345 on p47-phox serves as a priming signal of ROS-mediated axonal degeneration.
  Experimental Neurology, 352: 114024, 2022.

総説・著書

• 若月　修二
  small non-coding vault RNAによるシナプス形成の調節機構
  生化学　Journal of Japanese Biochemical Society 94(1): 78-81 (2022)

2021年

主な研究成果

• 非コードRNAが蛋白リン酸化酵素のはたらきを調節することによってシナプス形成を活発にする新しい仕組みを明らかにしました（2021年1月）

原著論文

• Wakatsuki S, Araki T.
  Novel Molecular Basis for Synapse Formation: Small Non-coding Vault RNA Functions as a Riboregulator of MEK1 to Modulate Synaptogenesis.
  Frontiers in Molecular Neuroscience 14: 748721, 2021.

• Nagano S, Araki T.
  Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases.
  Frontiers in Molecular Neuroscience 14: 697973, 2021.

• Hagihira H, et al (Wakatsuki S, Araki T as co-authors)
  Systematic analysis of brain lactate and pH levels in 65 animal models related to neuropsychiatric conditions
  bioRxiv 2021.02.02.428362

• Wakatsuki S, Ohno M, Araki T.
  Human vault RNA1-1, but not vault RNA2-1, modulates synaptogenesis.
  Communicative and Integrative Biology 14: 61-65, 2021.

• Koike S, Tanaka SC, Okada T, Aso T, Yamashita A, Yamashita O, Asano M, Maikusa N, Morita K, Okada N, Fukunaga M, Uematsu A, Togo H, Miyazaki A, Murata K, Urushibata Y, Autio J, Ose T, Yoshimoto J, Araki T, Glasser MF, Van Essen DC, Maruyama M, Sadato N, Kawato M, Kasai K, Okamoto Y, Hanakawa T, Hayashi T; Brain/MINDS Beyond Human Brain MRI Group.
  Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan
  NeuroImage: Clinical 8:102600, 2021.

• Klionsky DJ, et al. (Wakatsuki S, Araki T as co-authors)
  Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition)
  Autophagy 17(1) 1-382, 2021.

• Wakatsuki S, Takahashi Y, Shibata M, Adachi N, Numakawa T, Kunugi H, Araki T.
  Small non-coding vault RNA modulates synapse formation by amplifying MAPK signaling.
  Journal of Cell Biology. 220(2) e201911078, 2021.

• Uezumi A, Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Nakatani M, Hitachi K, Yamaguchi H, Wakatsuki S, Araki T, Morita M, Yamada H, Toyoda M, Kanazawa N, Nakazawa N, Hino J, Fukada S, Tsuchida K.
  Mesenchymally expressed Bmp3b maintains skeletal muscle integrity and reduction of its expression contributes to sarcopenia.
  Journal of Clinical Investigation. 131(1) e139617, 2021.

総説・著書

• Seiichi Nagano, Toshiyuki Araki
  Chapter 5: Axonal Transport and Local Translation of mRNA in Amyotrophic Lateral Sclerosis
  In: Araki T, editor. Amyotrophic Lateral Sclerosis. Brisbane (AU): Exon Publications; ISBN: 978-0-6450017-7-8; 2021

• 荒木敏之「神経軸索変性メカニズムの解明と神経保護的疾患治療法の開発への展開」
  日薬理誌（Folia Pharmacol. Jpn.）156，66～70（2021）

2020年

主な研究成果

• 筋萎縮性側索硬化症（ALS）、前頭側頭葉変性症（FTLD）の発症原因蛋白質TDP-43の新たな機能を明らかにした論文を発表しました（2020年8月）

原著論文

• Sasaki-Honda M, Kagita A, Jonouchi T, Araki T, Hotta A, Sakurai H.
  Generation of a transgene-free iPSC line and genetically modified line from a facioscapulohumeral muscular dystrophy type 2 (FSHD2) patient with SMCHD1 p.Lys607Ter mutation.
  Stem Cell Research. 147:101884, 2020.

• Nagano S, Jinno J, Abdelhamid RF, Jin Y, Shibata M, Watanabe S, Hirokawa S, Nishizawa M, Sakimura K, Onodera O, Okada H, Okada T, Saito Y, Takahashi-Fujigasaki J, Murayama S, Wakatsuki S, Mochizuki H, Araki T.
  TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons.
  Acta Neuropathologica. 140(5):695-713, 2020.

• Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE.
  NAD+ repletion rescues female fertility during reproductive aging.
  Cell Reports. Volume 30, February 2020, Pages 1670-1681

• Huang K, Masuda A, Chen G, Bushra S, Kamon M, Araki T, Kinoshita M, Ohkawara B, Ito M, Ohno K.
  Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells.
  Scientific Reports. Volume 10, February 2020, Pages 2558

総説・著書

• 栁下聡介
  閉塞性睡眠時無呼吸とアルツハイマー病との関係
  オベリスク No.25 issue 1, Jan, 2020.

• 栁下聡介
  閉塞性睡眠時無呼吸と認知機能低下　
  THE LUNG perspectives No.28 issue 1, Feb, 2020.

2019年

原著論文

• Araki T, Yamashita T.
  Mechanism of neuroaxonal degeneration: from molecular signaling to therapeutic applications
  Neuroscience Research Volume 139, February 2019, Pages 1-2

• Araki T, Wakatsuki S.
  Regulation of neuronal/axonal degeneration by ZNRF1 ubiquitin ligase.
  Neuroscience Research Volume 139, February 2019, Pages 21-25

• Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
  Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.
  Neuroscience Research Volume 139, February 2019, Pages 58-62

• Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
  Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
  Neuroscience Research Volume 139, February 2019, Pages 63-68

• Takahashi Y, Uchino A, Shioya A, Sano T, Matsumoto C, Numata-Uematsu Y, Nagano S, Araki T, Murata M, Murayama S, Saito Y.
  Altered immunoreactivity of ErbB4, a causative gene product for ALS19.
  Neuropathology　39: 268-278, 2019.

• Kondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T.
  Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury.
  Scientific Reports 9: 7188 (2019)

• Kondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S,Araki T, Goshima Y, Ohshima T.
  Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury.
  Biochem Biophys Res Commun　514 1037-1039, (2019)

• Tsubota M, Fukuda R, Hayashi Y, Miyazaki T, Ueda S, Yamashita R, Koike N, Sekiguchi F, Wake H, Wakatsuki S, Ujiie Y, Araki T, Nishibori M, Kawabata A.
  Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants.
  J Neuroinflammation 16(1):199, 2019.

総説・著書

• Toshiyuki Araki
  Regulatory Mechanism of Peripheral Nerve Myelination by Glutamate-Induced Signaling.
  Myelin Advances in Experimental Medicine and Biology No.1190 pp 23-31, November, 2019.

• 氏家悠佳, 若月修二, 荒木敏之
  低酸素応答による末梢神経の髄鞘形成制御　
  日本応用酵素協会誌No.53 pp 27-32, Mar, 2019.

• 荒木　敏之
  神経軸索変性メカニズムの研究と神経保護的疾患治療法の開発　
  「公益財団法人テルモ生命科学芸術財団　３０周年記念誌」 pp 48-49.

• 荒木　敏之
  神経変性・神経発達障害発症メカニズムにおける腸内細菌叢の寄与に関する研究　
  「ヤクルト・バイオサイエンス研究財団　年報」令和元年(2019年)版 pp 33-38.

2018年

総説・著書

• Toshiyuki Araki, Masayoshi Kamon, Hidetoshi Sakurai
  「Disease Modeling and Drug Development with DM1 Patient-Derived iPS Cells」　
  「Myotonic Dystrophy～Disease Mechanism, Current Management and Therapeutic Development」 pp 189-201. Ed by Masanori Takahashi, Tsuyoshi Matsumura.　Springer, 2018

• 栁下聡介
  「神経変性疾患では細胞内外に異常蛋白質が蓄積する」　
  「カラー図解 人体の細胞生物学 」 pp 254-255. 編者　坂井建雄. 石崎泰樹.　日本医事新報社, 2018

• Yagishita S
  「Chapter 7：Co-immunoprecipitation Assay to Investigate the Interaction Strength Between Synaptic Proteins Using COS-7 Cells」　
  「Co-Immunoprecipitation Methods for Brain Tissue」 pp 89-96. Ed by Yuji Odagaki, Dasiel O. Borroto-Escuela.　Springer, 2018

2017年

主な研究成果

• オートファジーが神経の変性を促進するしくみを明らかにした論文を発表しました（2017年1月）

総説・著書

• 荒木敏之「末梢神経の髄鞘化制御メカニズム」
  末梢神経　28巻1号 Page 16-22　日本末梢神経学会、名古屋　2017年

• 荒木敏之、若月修二「神経軸索変性の分子メカニズム」
  Dementia Japan 31巻2号　Page 252-257、　日本認知症学会　2017年

原著論文

• Galindo R, Greenberg M, Araki T, Sasaki Y, Mehta N, Milbrandt J, Holtzman D.
  NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.
  Annals of Clinical and Translational Neurology. 4(10): 722–738(2017)

• Imai S, Koyanagi M, Azimi Z, Nakazato Y, Matsumoto M, Ogihara T, Yonezawa A, Omura T, Nakagawa S, Wakatsuki S, Araki T, Kaneko S, Matsubara K.
  Taxanes and platinum derivatives impair Schwann cells prior to induction of neurotoxicity via distinct mechanisms.
  Sci Rep 7: 5947 (2017)

• Wakatsuki S, Araki T.
  GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.
  Communicative & Integrative Biology 10 (2) e1296615 (2017))

• Ueki J, Nakamori M, Nakamura M, Nishikawa M, YoshidaY, Tanaka A, Morizane A, Kamon M, Araki T, Takahash MP, Watanabe A, Inagaki N,Sakurai H.
  Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability.
  Sci Rep 7: 42522 (2017)

• Wakatsuki S, Tokunaga S, Shibata M, Araki T.
  GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.
  J Cell Biol 216(2):477-493 (2017)

2016年

総説・著書

• 荒木敏之「ミトコンドリア機能と末梢神経障害」
  末梢神経 27巻2号 Page151-153　日本末梢神経学会、名古屋　2016年

• 若月修二、荒木敏之「酸化ストレスを神経変性に変換する仕組み：鍵分子ZNRF1の活性化メカニズムと変性する軸索におけるオートファジー誘導」
  臨床免疫・アレルギー科66(4): 337-344 東京　科学評論社 2016年

• 荒木敏之、畠山英之、武田伸一「疾患特異的iPS細胞を活用した筋疾患研究」
  実験医学 34（4）：535－539、2016年

• Seiichi Nagano, Toshiyuki Araki「Role of Cysteine Residue of Mutant Cu, Zn-superoxide Dismutase (SOD1) in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)」
  「Novel Aspects of Amyotrophic Lateral Sclerosis」page 87-100 Humberto Foyaca Sibat；Lurdes de Fatima Ibanez Valdes編、「Update on Amyotrophic Lateral Sclerosis」INTECH（Croatia）2016年 ISBN 978-953-51-2601-0

原著論文

• Takahashi Y, Kanai M, Taminato T, Watanabe S, Matsumoto C, Araki T, Okamoto T, Ogawa M, Murata M.
  Compound heterozygous intermediate MJD alleles cause cerebellar ataxia with sensory neuropathy.
  Neurol Genet. 3(1): e123 (2016)
• Saito F, Wakatsuki S, Tokunaga S, Araki T.
  Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation.
  Sci. Rep. 6,: 29856 (2016)
• Wakatsuki S, Araki T.
  NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant.
  Communicative & Integrative Biology 9(2) e1143575 (2016)

2015年

主な研究成果

• 活性酸素の作用によって神経細胞内のZNRF1蛋白が 神経軸索と神経細胞崩壊を引き起こすことを示した論文を発表しました（2015年11月）

総説・著書

• Shuji Wakatsuki, Toshiyuki Araki
  「Significance of Mechanism-Oriented Research Toward Neuronal Protection Therapy Against Neurodegenerative Disorders ~ ZNRF1 E3 Ubiquitin Ligase as a Critical Mediator for Wallerian Degeneration and Neuronal Apoptosis」　
  「Neurodegenerative Disorders as Systemic Diseases 」 pp 159-182. Ed by Keiji Wada　Springer, 2015

原著論文

• Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T.
  A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice - Relevance to the pathogenesis of ALS.
  Hum Molec Genet 24(12):3427-39 (2015)
• Wakatsuki S, Furuno A, Ohshima M, Araki T.
  Oxidative stress-dependent phosphorylation activates ZNRF1 ubiquitin ligase to induce neuronal apoptosis and Wallerian degeneration.
  J Cell Biol. 211(4) 881-896 (2015)

2014年

原著論文

• Oie S, Matsuzaki K, Yokoyama W, Tokunaga, S, Waku T, Han SI, Iwasaki N, Mikogai A, Yasuzawa-Tanaka K, Hiyoshi H, Nakajima Y, Araki T, Kimura K, Yanagisawa J, Murayama A.
  Hepatic rRNA Transcription Regulates High-Fat Diet-Induced Obesity.
  Cell Reports 7(3): 807–820 (2014)
• Wakatsuki S, Araki T, Sehara A.
  Neuregulin-1/Glial Growth Factor stimulates Schwann Cell Migration by inducing the alpha5beta1 integrin–ErbB2–Focal Adhesion Kinase Complex Formation.
  Genes Cell 19(1):66-77 (2014)

2013年

原著論文

• Togashi K, Wakatsuki S, Furuno A, Tokunaga S, Nagai Y, Araki, T.
  Na+/H+ exchangers induce autophagy in neurons and inhibit polyglutamine-induced aggregate formation.
  PLoS One 8(11):e81313 (2013)
• Park JY, Jang SY, Shin YK, Koh H, Suh DJ, Tokunaga S, Araki T, Park HT.
  Mitochondrial swelling and microtubule depolymerization are associated with energy depletion in axon degeneration.
  Neuroscience. 238:258-269 (2013)

総説・著書

• 荒木敏之「神経軸索の変性からの保護と再生」
  末梢神経　Vol 24, No.2　pp205-209 2013年　日本末梢神経学会、名古屋

2012年

原著論文

• Araki T, Nagano S, Tateno M, Kaido M, Ogata K, Arima K.
  Misfolded SOD1 forms high-density molecular complexes with synaptic molecules in mutant SOD1-linked familial amyotrophic lateral sclerosis cases.
  J Neurol Sci. 314(1-2): 92-96 (2012)
• Tokunaga S, Araki T.
  Wallerian degeneration slow mouse neurons are protected against cell death caused by mechanisms involving mitochondrial electron transport dysfunction.
  J Neurosci Res. 90(3):664-671 (2012)

総説・著書

• 徳永慎治，荒木敏之「NAD合成経路改変によるミトコンドリア障害からの神経保護」
  実験医学　Vol 30, No.9　pp1418-1422 2012年　羊土社、東京
• 若月修二，荒木敏之 「ユビキチン・プロテアソーム系によって制御される軸索変性の分子メカニズム」
  生化学　Vol 84, No.6　pp463-471 2012年　日本生化学会、東京

2011年

主な研究成果

• リン酸化酵素の選択的分解により神経軸索変性が制御されることを示した論文を発表しました（2011年11月）

原著論文

• Wakatsuki S, Saitoh F, Araki T.
  ZNRF1 promotes Wallerian degeneration by degrading Akt to induce GSK3B-dependent CRMP-2 phosphorylation.
  Nature Cell Biol. 13:1415-1423 (2011)
• Takada H, Yuasa S, Araki T.
  Demyelination can proceed independently of axonal degradation during Wallerian degeneration in wlds mice.
  Eur J Neurosci. 34:531-537(2011)

2010年

原著論文

• Mitsuhashi H, Hayashi YK, Matsuda C, Noguchi S, Wakatsuki S, Araki T, Nishino I.
  Specific phosphorylation on Ser458 of A-type lamins in LMNA-associated myopathy patients.
  J Cell Sci. 123:3893-3900 (2010)
• Saitoh F, Araki T.
  Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation.
  J Neurosci. 30:1204-1212(2010)

2009年

主な研究成果

• グルタミン合成酵素によるグルタミン酸レベル調節による、末梢神経ミエリン形成のコントロールメカニズムに関する論文を発表しました（2009年12月）
• ミトコンドリアにおけるNAD合成系酵素の過剰発現が神経保護につながることを示した論文を発表しました（2009年4月）

原著論文

• Kabuta T, Kinugawa A, Tsuchiya Y, Kabuta C, Setsuie R, Tateno M, Araki T, Wada K,
  Familial amyotrophic lateral sclerosis-linked mutant SOD1 aberrantly interacts with tubulin.
  Biochem. Biophys. Res. Commun., 387:121-126, 2009
• Takada H, Kawana T, Ito Y, Kikuno RF, Mamada H, Araki T,
  Koga H, Asashima M, Taira M.
  The RNA binding protein Mex3b has a fine-tuning system for mRNA regulation in early Xenopus development.
  Development 136:2413-2422, 2009
• Yahata N, Yuasa S, Araki T.
  NMNAT expression in mitochondrial matrix delays Wallerian degeneration.
  J. Neurosci. 29: 6276-6284, 2009
• Wakatsuki S, Yumoto N, Komatsu K, Araki T, Sehara A.
  Roles of meltrin beta/ADAM19 in progression of Schwann cell differentiation and myelination during sciatic nerve regeneration.
  J. Biol.Chem. 284: 2957-2966, 2009
• Tateno M, Kato S, Sakurai T, Nukina N, Takahashi R, Araki T.
  Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3.
  Hum Mol Genet 18: 942-955, 2009

総論・著書

• 荒木敏之，八幡直樹 「神経軸索の変性と神経回路の修復」
  脳21　Vol 12, No.3　pp300-305 2009年　金芳堂、京都

2008年度

主な研究成果

• 家族性原因遺伝子産物である変異型によって引き起こされる神経軸索輸送障害（2008年12月）

～2007年度

原著論文

• Sasaki Y, Araki T, Milbrandt J :
  Stimulation of NAD biosynthetic pathways delays axonal degeneration after axotomy.
  J Neurosci. 26: 8484-8491, 2006.

総説・著書

• 荒木敏之 「軸索変性メカニズムと神経変性」
  神経変性疾患のサイエンス，編集:高橋良輔, 南山堂, 東京，pp.113-121, 2007
• 荒木敏之「神経変性疾患の神経再生」
  Congnition and Dementia. 6, pp.25-30, 2007
• 荒木敏之「軸索変性過程」
  先進 脳・神経科学，編集：中村俊，培風館，pp.135-143, 2006