Research

In order to elucidate the pathophysiology of intractable human diseases and develop treatment methods, it is necessary to use not only an easy-to-use rodent model but also a nonhuman primate model whose function and structure of the neural system are similar to those of humans. We target spinocerebellar degeneration (polyglutamine disease), familial Alzheimer's disease, stroke, etc. and make full use of reproductive engineering and gene modification technology to create disease models primates. Then, using these model animals, we aim to establish biomarkers that can sensitively reflect the onset of each disease and the progression of symptoms using various interdisciplinary approaches such as behavioral analysis, electrophysiology, biochemistry, pathology and functional brain imaging. Currently, research is underway on biomarker search for polyglutamine disease, generation of a marmoset model for familial Alzheimer's disease and analysis on a stroke model marmoset.