Cognitive Behavioral Therapy for Complex PTSD

We are conducting an open pre- and post-trial to evaluate the feasibility, safety, and efficacy of STAIR/NST, a cognitive-behavioral therapy for complex PTSD, in Japan. A translation of the STAIR/NST treatment principles and manual has also been published. In addition, we have prepared a Japanese version of the latest edition of the International Trauma Interview. （Kim, Niwa, Otaki)

A multilayered study of genes, biomarkers, and psycho-clinical indicators to elucidate the pathophysiology of PTSD and to develop a prediction method for treatment efficacy.

We will conduct gene analysis and expression analysis, endocrine and immune marker measurement, autonomic function analysis, brain MRI, cognitive function measurement, and psychological and clinical evaluation in trauma survivors (PTSD group and non-exposed group) and healthy subjects. We aim to develop an objective method of predicting treatment efficacy based on the index. The study is being conducted in collaboration with the Department of Psychiatry, Nagoya City University, and is ongoing with data collected on 248 patients so far. (Hori, Sekiguchi, Ito, Hayashi, Niwa, Kim, Otsuka, Narita, Kawanishi)

Open Clinical Trial on the Efficacy of Memantine for PTSD

To evaluate the efficacy of memantine, an anti-dementia drug, in patients with PTSD. The purpose of this study is to develop a protocol for RCTs by conducting an open clinical trial as a preliminary study to determine effect size and safety. A total of 10 patients were completed during this fiscal year, and the interim analysis results were published in a paper. Gene expression analysis, endocrine and immune system measurements, and brain MRI measurements will be conducted before and after memantine treatment to elucidate the mechanism of therapeutic effect and to develop a surrogate marker for therapeutic effect. (Hori, Sekiguchi, Ito, Narita, Kim)

Exploring Biomarkers of Mental Disorders Using Human Hair

The aim of this project is to identify biomarkers for psychiatric disorders such as mood disorders, psychotic disorders, and PTSD by measuring the concentrations of steroid hormones and other substances in hair. The study is being conducted in collaboration with the Third Department of Disease Research of the Institute of Neurology, the Center Hospital, and the MGC Bioresource Department, and recruitment of subjects is underway. (Hori)