Publications
Department of Degenerative Neurological Diseases
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略歴
≪学歴≫
- 2004年3月 東京大学大学院 農学生命科学研究科応用動物科学専攻 博士課程 修了
≪職歴≫
- 2004年4月 東京大学大学院 農学生命科学研究科応用動物科学専攻 リサーチフェロー
- 2004年5月 国立精神・神経医療研究センター 神経研究所 疾病研究第四部 外来研究員 (ヒューマンサイエンス振興財団)
- 2008年4月 国立精神・神経医療研究センター 神経研究所 疾病研究第四部 流動研究員
- 2010年 3月国立精神・神経医療研究センター 神経研究所 疾病研究第四部 室長
Publications -研究業績
原著・著書・総説
＜2023年＞
刊行物
原著
- Contu VR, Sakai R, Fujiwara Y, Kabuta C, Wada K, *Kabuta T. Nucleic acid uptake occurs independent of lysosomal acidification but dependent on ATP consumption during RNautophagy/DNautophagy. Biochem Biophys Res Commun. 2023;644:105-111.
＜2022年＞
刊行物
原著
- Fujiwara Y, Kabuta C, Sano T, Murayama S, Saito Y, *Kabuta T. Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients. Neurochem Int. 2022;152:105243.
＜2021年＞
刊行物
原著
- Fujiwara Y, Contu VR, Kabuta C, Ogawa M, Fujita H, Kikuchi H, Sakai R, Hase K, Suzuki M, Koyama-Honda I, Inoue M, Oya Y, Inoue Y, Inoue T, Takahashi R, Nishino I, Wada K, Noguchi S, *Kabuta T. Discovery of a protein uptake pathway in lysosomes. BioRxiv. doi: https://doi.org/10.1101/2020.08.11.245688 (preprint)
- *Takahashi M, Seki M, Nashimoto M, *Kabuta T. Perturbing the Normal Level of SIDT1 Suppresses the Naked ASO Effect. J Nucleic Acids. 2021;2021:2458470.
2020年以前
- Hase K, Contu VR, Kabuta C, Sakai R, Takahashi M, Kataoka N, Hakuno F, Takahashi SI, Fujiwara Y, Wada K, *Kabuta T. Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes. Autophagy. 2020;16(11):1974-1988.
- Nishikawa R, Osaki M, Sasaki R, Ishikawa M, Yumioka T, Yamaguchi N, Iwamoto H, Honda M, Kabuta T, Takenaka A, Okada F. Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells. Oncol Rep. 2020;44(5):1810-1820.
- Hirayama K, Fujiwara Y, Terada T, Shimizu K, Wada K, *Kabuta T. Virtual screening identification of novel chemical inhibitors for aberrant interactions between pathogenic mutant SOD1 and tubulin. Neurochem Int. 2019;126:19-26.
- Contu VR, Hase K, Kozuka-Hata H, Oyama M, Fujiwara Y, Kabuta C, Takahashi M, Hakuno F, Takahashi SI, Wada K, *Kabuta T. Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy. J Cell Sci. 2017;130(17):2843-2853.
- 紹介記事1: J Cell Sci. 2017 130: e1703
IN THIS ISSUE: SIDT2 function in RNautophagy.
- 紹介記事2: J Cell Sci. 2017 130: 2769-2770
First person – Viorica Raluca Contu
- Takahashi M, Contu VR, Kabuta C, Hase K, Fujiwara Y, Wada K, *Kabuta T. SIDT2 mediates gymnosis, the uptake of naked single-stranded oligonucleotides into living cells. RNA Biol. 2017;14(11):1534-1543.
- Aizawa S, Contu VR, Fujiwara Y, Hase K, Kikuchi H, Kabuta C, Wada K, *Kabuta T. Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes. Autophagy. 2017;13(1):218-222.
- Aizawa S, Fujiwara Y, Contu VR, Hase K, Takahashi M, Kikuchi H, Kabuta C, Wada K, *Kabuta T. Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes. Autophagy. 2016;12(3):565-578.
- Hatanaka Y, Wada K, *Kabuta T. Maternal high-fat diet leads to persistent synaptic instability in mouse offspring via oxidative stress during lactation. Neurochem. Int. 2016;97:99-108.
- Hase K, Fujiwara Y, Kikuchi H, Aizawa S, Hakuno F, Takahashi S, Wada K, *Kabuta T. RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates. Nucleic Acids Res. 2015;43(13):6439-6449.
- Kabuta C, Kono K, Wada K, *Kabuta T. 4-Hydroxynonenal induces persistent insolubilization of TDP-43 and alters its intracellular localization. Biochem Biophys Res Commun. 2015;463(1-2):82-87.
- Furuta A, Kikuchi H, Fujita H, Yamada D, Fujiwara Y, Kabuta T, Nishino I, Wada K, Uchiyama Y. Property of lysosomal storage disease associated with midbrain pathology in the central nervous system of Lamp-2-deficient mice. Am J Pathol. 2015;185(6):1713-1723.
- Hatanaka Y, Wada K, *Kabuta T. Abnormal instability, excess density, and aberrant morphology of dendritic spines in prenatally testosterone-exposed mice. Neurochem Int. 2015;85-86:53-58.
- Fujiwara Y, Hase K, Wada K, *Kabuta T. An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding. Biochem Biophys Res Commun. 2015;460(2):281-286.
- Nagamine S, Fujiwara Y, Shimizu T, Kawata A, Wada K, Isozaki E, Kabuta T. Association of ubiquitin carboxy-terminal hydrolase-L1 in cerebrospinal fluid with clinical severity in a cohort of patients with Guillain-Barré syndrome. Neurol Sci. 2015;36(6):921-926.
- Murphy K. E., Gysbers A. M., Abbott S. K., Spiro A. S., Furuta A., Cooper A., Garner B., Kabuta T. and Halliday G.M. LAMP2 protein isoforms are differentially affected in early Parkinson’s disease. Mov Disord. 2015;30(12):1639-1647.
- Koppensteiner P., Aizawa S., Yamada D., Kabuta T., Boehm S., Wada K. and Sekiguchi M. Age-dependent sensitivity to glucocorticoids in the developing mouse basolateral nucleus of the amygdala. Psychoneuroendocrinology. 2014;46, 64-77.
- *Kabuta T., Mitsui T., Takahashi M., Fujiwara Y., Kabuta C., Konya C., Tsuchiya Y., Hatanaka Y., Uchida K., Hohjoh H. and Wada K. UCH-L1 acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation, independent of its hydrolase activity. J Biol Chem. 2013;288, 12615-12626.
- Yoneyama Y., Matsuo M., Take K., Kabuta T., Chida K., Hakuno F. and Takahashi SI. AP-1 complex regulates intracellular localization of insulin receptor substrate-1 required for insulin-like growth factor-I-dependent cell proliferation. Mol Cell Biol. 2013;33,1991-2003.
- Fujiwara Y., Kikuchi H., Aizawa S., Furuta A., Hatanaka Y., Konya C., Uchida K., Wada K. and *Kabuta T. Direct uptake and degradation of DNA by lysosomes. Autophagy 2013;9, 1167-1171.
- Fujiwara Y., Furuta A., Kikuchi H., Aizawa S., Hatanaka Y., Konya C., Uchida K., Yoshimura A., Tamai Y., Wada K. and *Kabuta T. Discovery of a novel type of autophagy targeting RNA. Autophagy 2013;9, 403-409.
- 紹介記事: RNA Biology, 2013, 10, 463-464,
Novel type of autophagy discovered: RNautophagy.
- Higashi S., Kabuta T, Nagai Y., Tsuchiya Y., Akiyama H. and Wada K. TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress. J Neurochem. 2013;126, 288-300.
- Furuta A., Wakabayashi K., Haratake J., Kikuchi H., Kabuta T., Mori F., Tokonami F., Katsumi Y., Tanioka F., Uchiyama Y., Nishino I. and Wada K. Lysosomal storage and advanced senescence in the brain of LAMP-2-deficient Danon disease. Acta Neuropathol. 2013;125, 459-461.
- Morita M., Ler L. W., Fabian M. R., Siddiqui N., Mullin M., Henderson V. C., Alain T., Fonseca B. D., Karashchuk G., Bennett C. F., Kabuta T., Higashi S., Larsson O., Topisirovic I., Smith R. J., Gingras A. C. and Sonenberg N. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012;32, 3585-3593.
- Konya C., Hatanaka Y., Fujiwara Y., Uchida K., Nagai Y., Wada K. and *Kabuta T. Parkinson's disease-associated mutations in alpha-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L1. Neurochem Int. 2011;59, 251-258.
- Higashi S., Moore D. J., Minegishi M., Kasanuki K., Fujishiro H., Kabuta T., Togo T., Katsuse O., Uchikado H., Furukawa Y., Hino H., Kosaka K., Sato K., Arai H., Wada K. and Iseki E. Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies. J Neuropathol Exp Neurol. 2011;70, 264-280.
- Yamamoto K., Yamada D., Kabuta T., Takahashi A., Wada K. and Sekiguchi M. Reduction of abnormal behavioral response to brief restraint by information from other mice in dystrophin-deficient mdx mice. Neuromuscul Disord. 2010;20, 505-511.
- Nagamine S., Kabuta T., Furuta A., Yamamoto K., Takahashi A. and Wada K. Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation. Neurochem Int. 2010;57, 102-110.
- Mitsui T., Hirayama K., Aoki S., Nishikawa K., Uchida K., Matsumoto T., *Kabuta T. and Wada K. Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening. Neurochem Int. 2010;56, 679-686.
- Kabuta T., Hakuno F., Cho Y., Yamanaka D., Chida K., Asano T., Wada K. and Takahashi S. Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity. Biochem Biophys Res Commun. 2010;394, 697-702.
- Higashi S., Tsuchiya Y., Araki T., Wada K. and *Kabuta T. TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase. Neurochem Int. 2010;57, 906-913
- Higashi S., Iseki E., Minegishi M., Togo T., *Kabuta T. and Wada K. GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. J Neurochem. 2010;115, 423-437.
- Yasuda T., Nihira T., Ren Y. R., Cao X. Q., Wada K., Setsuie R., Kabuta T., Wada K., Hattori N., Mizuno Y. and Mochizuki H. Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease. J Neurochem. 2009;108, 932-944.
- Setsuie R., Suzuki M., Kabuta T., Fujita H., Miura S., Ichihara N., Yamada D., Wang Y. L., Ezaki O., Suzuki Y. and Wada K. Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle. FASEB J. 2009;23, 4148-4157.
- *Kabuta T., Kinugawa A., Tsuchiya Y., Kabuta C., Setsuie R., Tateno M., Araki T. and Wada K. Familial amyotrophic lateral sclerosis-linked mutant SOD1 aberrantly interacts with tubulin. Biochem Biophys Res Commun. 2009;387, 121-126
- Goto A., Wang Y. L., Kabuta T., Setsuie R., Osaka H., Sawa A., Ishiura S. and Wada K. Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse. Neurochem Int. 2009;54, 330-338.
- Sakurai M., Sekiguchi M., Zushida K., Yamada K., Nagamine S., Kabuta T. and Wada K. Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene. Eur J Neurosci. 2008;27, 691-701.
- *Kabuta T. and Wada K. Insights into links between familial and sporadic Parkinson's disease: physical relationship between UCH-L1 variants and chaperone-mediated autophagy. Autophagy 2008;4, 827-829.
- Kabuta T., Take K., Kabuta C., Hakuno F. and Takahashi S. Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta. Biochem Biophys Res Commun. 2008;377, 741-746.
- *Kabuta T., Setsuie R., Mitsui T., Kinugawa A., Sakurai M., Aoki S., Uchida K. and Wada K. Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1. Hum Mol Genet. 2008;17, 1482-1496.
- *Kabuta T., Furuta A., Aoki S., Furuta K. and Wada K. Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J Biol Chem. 2008;283, 23731-23738.
- Setsuie R., Wang Y. L., Mochizuki H., Osaka H., Hayakawa H., Ichihara N., Li H., Furuta A., Sano Y., Sun Y. J., Kwon J., Kabuta T., Yoshimi K., Aoki S., Mizuno Y., Noda M. and Wada K. Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant. Neurochem Int. 2007;50, 119-129.
- Kabuta T., Suzuki Y. and Wada K. Degradation of amyotrophic lateral sclerosis-linked mutant Cu,Zn-superoxide dismutase proteins by macroautophagy and the proteasome. J Biol Chem. 2006;281, 30524-30533.
- Zhang X., Kamaraju S., Hakuno F., Kabuta T., Takahashi S., Sachdev D. and Yee D. Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression. Breast Cancer Res Treat. 2004;83, 161-170.
- Kabuta T, Hakuno F, Asano T, Takahashi S. Insulin receptor substrate-3 functions as transcriptional activator in the nucleus. J Biol Chem. 2002;277, 6846-6851.
- 紹介記事: Science Signaling (Science STKE), 2002, 122, tw96,
EDITORS' CHOICE, TRANSCRIPTION: Nuclear IRS-3 Can Transactivate Genes.
