Publications

＜2023年＞

刊行物

原著

• Nakamura R, Tomizawa I, Iwai A, Ikeda T, Hirayama K, Chiu YW, Suzuki T, Tarutani A, Mano T, Iwata A, Toda T, Sohma Y, Kanai M, Hori Y, Tomita T: Photo-oxygenation of histidine residue inhibits α-synuclein aggregation. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 37(12):e23311, December, 2023
• Murai SA, Mano T, Sanes JN, Watanabe T: Atypical intrinsic neural timescale in the left angular gyrus in Alzheimer’s disease. medRxiv, 2023–2006, 2023
• Okubo S, Mano T, Sudo A, Goto R, Yano S, Hara M, Ishiura H, Satake W, Yanagimoto S, Ogata H, Toda T: Anti-neurofascin 155 Antibody-positive Neuropathy in a Human Immunodeficiency Virus-infected Patient. Internal Medicine , , June, 2023 , https://doi.org/10.2169/internalmedicine.1919-23

著書・総説

＜2022年＞

刊行物

原著

• Sato K, Niimi Y, Mano T, Iwata A, Iwatsubo T: Automated Evaluation of Conventional Clock-Drawing Test Using Deep Neural Network: Potential as a Mass Screening Tool to Detect Individuals With Cognitive Decline. Frontiers in Neurology, May, 202213:896403, 10.3389/fneur.2022.896403, 査読有
• Sato K, Niimi Y, Mano T, Iwata A, Iwatsubo T: Automated Evaluation of Conventional Clock-Drawing Test Using Deep Neural Network: Potential as a Mass Screening Tool to Detect Individuals With Cognitive Decline. Frontiers in Neurology, 13:896403, May, 2022
• Sato K, Niimi Y, Mano T, Iwata A, Iwatsubo T: Time to onset of drug-induced parkinsonism: Analysis using a large Japanese adverse event self-reporting database. Bioscience trends, Apr, 2022, 16(2):151-57, 10.5582/bst.2022.01115, 査読有
• Sato K, Iwata A, Kurihara M, Mano T, Toda T: Stress cardiomyopathy (Takotsubo syndrome) in patients who received adrenergic agonist drugs: A pharmacovigilance study using the Japanese Adverse Drug Event Report (JADER) database. Journal of Cardiology, 79(1):36–41, January, 2022

著書・総説

• Tatsuo Mano, Atsushi Iwata, Academic press, Autophagy dysfunction in Alzheimer’s disease and dementia, 2022年8月
• 間野達雄、岩田淳、中外医学社、Clinical Neuroscience Exosomeと疾患 アルツハイマー病、2022年7月
• 間野達雄、岩田淳、ワールドプランニング、老年精神医学雑誌 加齢脳とエピジェネティクス異常、2022年7月
• 間野達雄，岩田淳：神経変性疾患とエピジェネティクス．病理と臨床，40巻2号，pp142-148，2022年2月

＜2021年＞

刊行物

原著

• Watanabe N, Nakano M, Mitsuishi Y, Hara N, Mano T, Iwata A, Murayama S, Suzuki T, Ikeuchi T, Nishimura M: Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain. Human Molecular Genetics, 31(1):122–132, December, 2021
• Sato K, Mano T, Niimi Y, Toda T, Iwata A, Iwatsubo T: Facial nerve palsy following the administration of COVID-19 mRNA vaccines: analysis of a self-reporting database. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases, 111:310–312, October, 2021
• Sato K, Mano T, Niimi Y, Iwata A, Toda T, Iwatsubo T: The impact of COVID-19 pandemic on the utilization of ambulatory care for patients with chronic neurological diseases in Japan: Evaluation of an administrative claims database. Bioscience Trends, 15(4):219–230, September, 2021
• Kikuchi JK, Nagashima Y, Mano T, Ishiura H, Hayashi T, Shimizu J, Matsukawa T, Ichikawa Y, Takahashi Y, Karino S, Kanbayashi T, Kira J, Goto J, Tsuji S: Cerebellar Ataxia as a Common Clinical Presentation Associated with DNMT1 p.Y511H and a Review of the Literature. Journal of Molecular Neuroscience: MN, 71(9):1796–1801, September, 2021
• Sato K, Mano T, Iwata A, Toda T: Safety of Memantine in Combination with Potentially Interactive Drugs in the Real World: A Pharmacovigilance Study Using the Japanese Adverse Drug Event Report (JADER) Database. Journal of Alzheimer’s Disease: JAD, 82(3):1333–1344, August, 2021
• Sato K, Mano T, Iwata A, Toda T: Need of care in interpreting Google Trends-based COVID-19 infodemiological study results: potential risk of false-positivity. BMC Medical Research Methodology, 21(1):147, July, 2021
• Mano T, Sato K, Ikeuchi T, Toda T, Iwatsubo T, Iwata A: Peripheral Blood BRCA1 Methylation Positively Correlates with Major Alzheimer’s Disease Risk Factors. The Journal of Prevention of Alzheimer’s Disease, 8(4):477–482, June, 2021

著書・総説

• 間野達雄，岩田淳：ヘテラルキーからみた神経疾患と治療 エピゲノム．Clinical Neuroscience，39巻７号，pp864-867, 2021年７月
• 間野達雄，岩田淳：Parinaud症候群．Clinical Neuroscience，39巻5号，pp632-633, 2021年5月

2020年以前

• Kawai M, Mano T, Naito T, Honda A, Nakai Y, Toyama K, Fujioka Y, Makise N, Hasegawa H, Sakuishi K, Kurokawa M, Toda T: Disseminated necrotizing leukoencephalopathy after allogeneic peripheral blood stem cell transplantation and methotrexate administration. Neurology and Clinical Neuroscience, 9(1):155–156, January, 2021
• Ueda K, Seto A, Mano T, Toda T: Isolated Body Lateropulsion in Supplementary Motor Area Infarction. Internal Medicine , 59(23):3113–3114, December, 2020
• Kurihara M, Orimo K, Mano T, Miyano R, Kamisawa Sato A, Sato K, Ihara R, Hayashi T, Toda T: Gait improvement after levofloxacin administration in a progressive supranuclear palsy patient. Clinical Parkinsonism & Related Disorders, 3:100080, November, 2020
• Sato K, Mano T, Iwata A, Toda T: Autocorrelation-based method to identify disordered rhythm in Parkinson’s disease tasks: A novel approach applicable to multimodal devices. PloS One, 15(10):e0238486, October, 2020a
• Nakamura N, Tsunoda K, Mitsutake A, Shibata S, Mano T, Nagashima Y, Ishiura H, Iwata A, Toda T, Tsuji S, Sawamura H: Clinical Characteristics of Neuronal Intranuclear Inclusion Disease-Related Retinopathy With CGG Repeat Expansions in the NOTCH2NLC Gene. Investigative Ophthalmology & Visual Science, 61(11):27, September, 2020
• Sato K, Mano T, Suzuki K, Toda T, Iwatsubo T, Iwata A, for Alzheimer’s Disease Neuroimaging Initiative: Attempt to Predict A/T/N-Based Alzheimer’s Disease Cerebrospinal Fluid Biomarkers Using a Peripheral Blood DNA Methylation Clock. Journal of Alzheimer’s Disease Reports, 4(1):287–296, July, 2020
• Sato K, Mano T, Iwata A, Toda T: Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database. Bioscience Trends, 14(2):139–143, May, 2020b
• Mano T, Nakayama T, Endo H, Bono K, Imafuku I: Non-invasive visualization of arterial stagnation in a dissected internal carotid artery. Journal of the Neurological Sciences, 412:116760, May, 2020
• Koshi-Mano K, Mano T, Morishima M, Murayama S, Tamaoka A, Tsuji S, Toda T, Iwata A: Neuron-specific analysis of histone modifications with post-mortem brains. Scientific Reports, 10(1):3767, February, 2020
• Kurihara M, Mano T, Saito Y, Murayama S, Toda T, Iwata A: Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies. Brain Sciences, 10(1), December, 2019, https://doi.org/10.3390/brainsci10010007
• Sato K, Mano T, Iwata A, Toda T: Subtype-Dependent Reporting of Stroke With SGLT2 Inhibitors: Implications From a Japanese Pharmacovigilance Study. Journal of Clinical Pharmacology, 60(5):629–635, December, 2019a
• Sato K, Nagashima Y, Mano T, Iwata A, Toda T: Quantifying normal and parkinsonian gait features from home movies: Practical application of a deep learning-based 2D pose estimator. PloS One, 14(11):e0223549, November, 2019
• Sato K, Mano T, Iwata A, Toda T: Neurological and related adverse events in immune checkpoint inhibitors: a pharmacovigilance study from the Japanese Adverse Drug Event Report database. Journal of Neuro-Oncology, 145(1):1–9, October, 2019
• Sato K, Iwata A, Kurihara M, Nagashima Y, Mano T, Toda T: Estimating acceleration time point of respiratory decline in ALS patients: A novel metric. Journal of the Neurological Sciences, 403:7–12, August, 2019
• Ishiura H, Shibata S, Yoshimura J, Suzuki Y, Qu W, Doi K, Almansour MA, Kikuchi JK, Taira M, Mitsui J, Takahashi Y, Ichikawa Y, Mano T, Iwata A, Harigaya Y, Matsukawa MK, Matsukawa T, Tanaka M, Shirota Y, … Tsuji S: Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease. Nature Genetics, 51(8):1222–1232, August, 2019
• Sato K, Mano T, Matsuda H, Senda M, Ihara R, Suzuki K, Arai H, Ishii K, Ito K, Ikeuchi T, Kuwano R, Toda T, Iwatsubo T, Iwata A, Japanese Alzheimer’s Disease Neuroimaging Initiative: Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer’s disease by applying methodology from gene co-expression analysis. NeuroImage. Clinical, 24:101957, July, 2019
• Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A: Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight. Scientific Reports, 9(1):2827, February, 2019
• Sato K, Mano T, Ihara R, Suzuki K, Tomita N, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Iwatsubo T, Toda T, Iwata A, Alzheimer’s Disease Neuroimaging Initiative, and Japanese Alzheimer's Disease Neuroimaging Initiative: Lower Serum Calcium as a Potentially Associated Factor for Conversion of Mild Cognitive Impairment to Early Alzheimer’s Disease in the Japanese Alzheimer's Disease Neuroimaging Initiative. Journal of Alzheimer’s Disease: JAD, 68(2):777–788, March, 2019
• Yamaguchi N, Mano T, Ohtomo R, Ishiura H, Almansour MA, Mori H, Kanda J, Shirota Y, Taira K, Morikawa T, Ikemura M, Yanagi Y, Murayama S, Shimizu J, Sakurai Y, Tsuji S, Iwata A: An Autopsy Case of Familial Neuronal Intranuclear Inclusion Disease with Dementia and Neuropathy. Internal Medicine , 57(23):3459–3462, December, 2018
• Kurihara M, Mano T, Arakawa A, Iwata A, Toda T: Isolated unilateral ptosis due to midbrain infarction. Neurology and Clinical Neuroscience, 6(6):199–199, November, 2018
• Tsuchida T, Mano T, Koshi-Mano K, Bannai T, Matsubara T, Yamashita S, Ushijima T, Nagata K, Murayama S, Toda T, Tsuji S, Iwata A: Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons. Brain Research, 1697:59–66, October, 2018
• Kodama S, Mano T, Kakumoto T, Ishiura H, Hagiwara A, Kamiya K, Hayashi T, Tsuji S: Ketotic hyperglycemia-related seizure with reversible white matter lesion: Metabolic implication of its reversibility based on magnetic resonance spectroscopy study. Journal of the Neurological Sciences, 390:20–21, July, 2018
• Nagata K, Mano T, Murayama S, Saido TC, Iwata A: DNA methylation level of the neprilysin promoter in Alzheimer’s disease brains. Neuroscience Letters, 670:8–13, March, 2018
• Ohtomo G, Mano T, Seto A, Tsuji S: Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction. Internal Medicine , 57(5):767–768, March, 2018
• Takumida H, Yakabe M, Mori H, Shibasaki K, Umeda-Kameyama Y, Urano T, Mano T, Hayashi A, Ikemura M, Ogawa S, Akishita M: Case of a 78-year-old woman with a neuronal intranuclear inclusion disease. Geriatrics & Gerontology International, 17(12):2623–2625, December, 2017
• Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, … Iwata A: Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America, 114(45):E9645–E9654, November, 2017
• Kodama S, Mano T, Masuzawa A, Hirata Y, Nagasako Y, Koshi Mano K, Hamada M, Terao Y, Hayashi T, Ono M, Tsuji S: Tacrolimus-Induced Reversible Cerebral Vasoconstriction Syndrome with Delayed Multi-Segmental Vasoconstriction. Journal of Stroke and Cerebrovascular Diseases: The Official Journal of National Stroke Association, 26(5):e75–e77, May, 2017
• Mano T, Saito M, Yoshizawa T: Axonal invasion of Listeria monocytogenes: Implications for early diagnosis with magnetic resonance imaging. Journal of the Neurological Sciences, 373:7–8, February, 2017
• Mano T, Suzuki T, Tsuji S, Iwata A: Differential effect of HDAC3 on cytoplasmic and nuclear huntingtin aggregates. PloS One, 9(11):e111277, November, 2014
• Mano T, Endo Y, Nakayama T, Murayama S, Imafuku I: [Case report; A 81-year-old immunocompetent male case with severe varicella-zoster encephalitis: an autopsy case]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(2):440–443, February, 2013
• Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H: Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29(43):13720–13729, October, 2009
• Takemoto-Kimura S, Ageta-Ishihara N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H, Bito H: Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Neuron, 54(5):755–770, June, 2007

著書

総説

• 間野達雄：長寿フロントライン Alzheimer病剖検脳の神経細胞特異的メチル化解析から明らかになった、神経変性におけるDNA傷害蓄積の重要性．長寿フロントライン，29巻１号，pp38-41, 2020年４月
• 間野達雄, 岩田淳, 神経変性疾患におけるエピゲノムの役割．遺伝子医学, 10巻１号，pp42-48，2020年１月
• 間野達雄, 岩田淳, アルツハイマー病のエピジェネティクス. 医学のあゆみ, 267巻8号, pp612-614, 2018年８月
• 間野達雄, 岩田淳. Current topics: 神経細胞特異的メチル化解析から明らかになったアルツハイマー病におけるDNA修復の障害. 実験医学, 36巻4号, pp556-559, 2018年３月
• 間野かがり，間野達雄，岩田淳. 神経変性におけるDNAメチル化. 医学のあゆみ, 264巻10号, pp912-913, 2018年３月
• 間野達雄, 岩田淳. 認知症のエピジェネティクス. 実験医学, 35巻12号, pp2030-2033, 2017年８月
• 間野達雄, 岩田淳. 神経変性疾患とエピジェネティクス. アンチ・エイジング医学, 12巻6号,pp776-782, 2017年１月
• 間野達雄, 岩田淳. 神経核内封入体病の病態生理. 神経内科, 85巻6号, pp624-630, 2016年12月
• 間野かがり, 間野達雄, 岩田淳. アルツハイマー型認知症発症機構の解明はどこまで進んだか. Phama Medica, 34巻7号, pp13-17, 2016年7月
• 間野達雄, 今福一郎. しゃべりにくい、言葉がもつれる. 内科, 113巻5号, pp829-831, 2014年5月

学会発表

国際学会

[招待講演]

• Tatsuo Mano: “Neuro-epigenetic approach to Alzheimer’s disease” Online Workshop 2021 on Sustainable Development, Stockholm-Tokyo University Partnership, 2021.9.27, (Online)

[一般講演]

• Tatsuo Mano, Atsushi Iwata, Takashi Nonaka, Airi Tarutani, Tadafumi Hashimoto, Masato Hasegawa, Takeshi Iwatsubo, Tatsushi Toda: “Tau-related dysfunction of BRCA1 lead to reduced neuronal plasticity in Alzheimer’s disease” AAIC2018: The Alzheimer's Association International Conference, 2018.7.24 (Chicago, USA)
• Tatsuo Mano,Kenichi Nagata, Shigeo Murayama,Takaomi C. Saido,Shoji Tsuji,Atsushi Iwata: “Genome-wide analysis of neuron specific DNA methylation in Alzheimer’s disease” ICHG2016 : The 13th International Congress of Human Genetics, 2016. 4. 5 (Kyoto Japan)
　

国内学会

[招待講演]

• 間野達雄, 岩田淳：「アルツハイマー病の病態解明におけるエピゲノムアプローチ」第43回日本分子生物学会年会, シンポジウム, 2020年12月1日（オンライン）
• 間野達雄, 岩田淳：「Genomic integrity in Alzheimer's disease」 第61回日本神経学会, シンポジウム, 2020年5月20日(岡山)
• 間野達雄, 岩田淳：「アルツハイマー病に対する神経細胞特異的なエピゲノムアプローチ」 第64回人類遺伝学会, シンポジウム, 2019年11月9日(長崎)
• 間野達雄, 岩田淳：「アルツハイマー病におけるDNA傷害の蓄積と神経細胞機能への影響」 第37回日本認知症学会, シンポジウム, 2018年10月14日(札幌)