国立研究開発法人 国立精神・神経医療研究センター神経研究所ラジオアイソトープ管理室

業績

学術論文

原著

  1. Nakaya M, Sato N, Matsuda H, Maikusa N, Shigemoto Y, Sone D, Yamao T, Ogawa M, Kimura Y, Chiba E, Ohnishi M, Kato K, Okita K, Tsukamoto T, Yoki Y, Sakata M, Abe O: Free water derived by multi-shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer’s disease. Altzheimer’s Dement. 2022;8e12356.
  2. Okita K, Matsumoto T, Funada D, Murakami M, Kato K, Shigemoto Y, Sato N, Matsuda H: Potential treat-to-target approach for methamphetamine use disorder: A pilot study of adenosine 2A receptor antagonist with positron emission tomography. Frontiers in Pharmacology 13, 820447, 2022.
  3. Okita K, Kato K, Shigemoto Y, Sato N, Matsumoto T, Matsuda H: Effects of adenosine A2A receptor antagonist on striatal dopamine D2-type receptor availability: A randomized control study using positron emission tomography. Frontiers in Neurosciences 15, 729153, 2021.
  4. Shintani Y, Kato K, Kawami M, Takano M, Kumamoto T: Direct N1-selective alkylation of hydantoins using potassium bases. Chem. Pharm. Bull. 69, 407-411, 2021.
  5. Shigemoto Y, Sone D, Okita K, Maikusa N, Yamao T, Kimura Y, Suzuki F, Fujii H, Kato K, Sato N, Matsuda H：Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients. eNeurological Sci. 22: 100309.
  6. Sone D, Shigemoto Y, Ogawa M, Maikusa N, Okita K, Takano H, Kato K, Sato N, Matsuda H: Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease. Alzheimers Dement. 12(1): e12125.
  7. Hori Y*, Ihara N, Sugai C, Ogura J, Honda M, Kato K, Isomura Y, Hanakawa T: Ventral striatum links motivational and motor networks during operant-conditioned movement in rat. NeuroImage 184: 943-53, 2019.
  8. Sudo H, Tsuji AB*, Sugyo A, Okada M, Kato K, Zhang MR, Saga T, Higashi T: Direct comparison of 2-amino[3-11C]isobutyric acid and 2-amino[11C]methyl-isobutyric acid uptake in eight lung cancer xenograft models. Int. J. Oncol. 53: 2737-2744, 2018.
  9. Shigemoto Y, Sone D, Maikusa N, Okamura N, Furumoto S, Kudo Y, Ogawa M, Takano H, Sakata M, Tsukamoto T, Kato K, Sato N, Matsuda H*: Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer’s disease spectrum patients. Brain Behav. 8: e01145, 2018.
  10. Shigemoto Y, Sone D, Imabayashi E, Maikusa N, Okamura N, Furumoto S, Kudo Y, Ogawa M, Takanp H, Yokoi Y, Sakata M, Tsukamoto T, Kato K, Sato N, Matsuda H*: Dissociation of tau deposits and brain atrophy in early Alzheimer’s disease: A combined positron emission tomography/magnetic resonance imaging study. Front. Aging Neurosci. 10.3389/fnagi.2018.00223.
  11. Ota M*, Ogura J, Ogawa S, Kato K, Matsuda H, Kunugi H: A single intraperitoneal injection of endotoxin changes glial cells in rats as revealed by positron emission tomography using [11C]PK11195. Nucl. Med. Mol. Imaging 52: 224-228, 2018.
  12. Ogawa S, Ota M, Ogura J, Kato K, Kunugi H*: Effect of L-theanine on anxiety-like behavior, cerebrospinal fluid amino acid profile, and hippocampal activity in Wister Kyoto rats. Psychopharmacology 235: 37-45, 2018.
  13. Tateishi H, Tsuji AB*, Kato K*, Sudo H, Sugyo A, Hanakawa T, Zhang MR, Saga T, Arano Y, Higashi T: Synthesis and evaluation of 11C-labeled coumarin analog as an imaging probe for detecting monocarboxylate transporters expression. Bioorg Med. Chem. Lett. 27: 4893-97, 2017.
  14. Sone D, Imabayashi E, Maikusa N, Okamura N, Furumoto S, Kudo Y, Ogawa M, Takano H, Yokoi Y, Sakata M, Tsukamoto T, Kato K, Matsuda H*: Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer’s disease: A combined positron emission tomography/magnetic resonance imaging study. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring 9: 35- 40, 2017.
  15. Okada M*, Kikuchi T, Ikoma Y, Tsuji AB, Wakizaka H, Okamura T, Kamakura T, Aoki I, Zhang MR, Kato K: In vivo imaging of blood-brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid. Nucl Med. Commun. 36: 1239-1248, 2015.
  16. Ota M*, Ogawa S, Kato K, Masuda C, Kunugi H: Striatal and extrastriatal dopamine release in the common marmoset brain measured by positron emission tomography and [18F]fallypride. Neuroscience Res. 101: 1- 5, 2015.
  17. Suzuki C, Tsuji AB*, Kato K, Sudo H, Zhang MR, Saga T: Preclinical evaluation of 2-amino-2-[11C]methyl-butanoic acid as a potential tumor imaging agent in a mouse model. Nucl. Med. Commun. 36: 1107-12, 2015.
  18. Hori Y*, Ihara N, Teramoto N, Kunimi M, Honda M, Kato K, Hanakawa T*: Noninvasive quantification of cerebral metabolic rate for glucose in rats using 18F-FDG PET and standard function. J. Cereb. Blood Flow Metab. 35:1664-70, 2015.
  19. Ota M*, Ogawa S, Kato K, Wakabayashi C, Kunugi H: Methamphetamine-sensitized rats show augmented dopamine release to methylphenidate stimulation: A positron emission tomography using [18F]fallypride. Psychiatry Res 232: 92-97, 2015.
  20. Tsuji AB*, Sugyo A, Sudo H, Suzuki C, Wakizaka H, Zhang MR, Kato K, Saga T: Preclinical assessment of early tumor response after irradiation by positron emission tomography with 2-amino-[3-11C]isobutyric acid. Oncology Reports. 33: 2361-67, 2015.
  21. Suzuki C, Kato K*, Tsuji AB, Zhang MR, Arano Y, Saga T: Inhibition of radical reactions for an improved potassium tert-butoxide-promoted 11C-methylation strategy for the synthesis of α-11C-methyl amino acids. J. Label. Compd. Radiopharm. 58: 127-32, 2015.
  22. Suzuki C, Tsuji AB*, Kato K, Kikuchi T, Sudo H, Okada M, Sugyo A, Zhang MR, Arano Y, Saga T: Preclinical characterization of 5-amino-4-oxo-[6-11C]hexanoic acid as an imaging tracer probe to estimate protoporphyrin IX accumulation induced by exogenous aminolevlinic acid. J. Nucl. Med. 55: 1671-1677, 2014.
  23. Takashima M, Kato K*, Ogawa M, Magata Y: One-pot sequential reactions for the synthesis of versatile 11C-labeled olefin frameworks. RSC Adv. 3: 21275-79, 2013.
  24. Kikuchi T, Minegishi K, Hashimoto H, Zhang MR, Kato K*: The use tetrabutylammonium fluoride to promote N- and O-11C-methylation reactions with iodo[11C]methane in DMSO. J. Label. Compd. Radiopharm. 56: 672-78, 2013.
  25. Suzuki C, Kato K*, Tsuji AB, Kikuchi T, Zhang MR, Arano Y, Saga T: Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX. Bioorg. Med. Chem. Lett. 23: 4567-70, 2013.
  26. Tsuji AB*, Kato K, Sugyo A, Okada M, Sudo H, Yoshida C, Wakizaka H, Zhang MR, Saga T: Comparison of 2-amino-[3-11C]isobutyric acid and 2-deoxy-2-[18F]fluoro-D-glucose in nude mice with xenografted tumors and acute inflammation. Nucl. Med. Commun. 33: 1058-1064, 2012.
  27. Kikuchi T, Okada M, Nengaki N, Furutsuka K, Wakizaka H, Okamura T, Zhang MR, Kato K*: Efficient synthesis and chiral separation of 11C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography. Bioorg. Med. Chem. 19: 3265-3273, 2011.
  28. Asakawa C, Ogawa M, Kumata K, Fujinaga M, Kato K, Yamasaki T, Yui J, Kawamura K, Hatori A, Fukumura T, Zhang MR*: [11C]Sorafenib: radiosynthesis and preliminary PET study of brain uptake mediated by P-glycoprotein and breast cancer resistance protein. Bioorg. Med. Chem. Lett. 21: 2220-2223, 2011.
  29. Kato K*, Tsuji AB, Saga T, Zhang MR: An Efficient and Expedient Method for the Synthesis of 11C-labeled α-Aminoisobutyric Acid: A Tumor Imaging Agent Potentially Useful for Cancer Diagnosis. Bioorg. Med. Chem. Lett. 21: 2437-2440, 2011.
  30. Kato K*, Zhang MR, Minegishi K, Nengaki N, Takei M, Suzuki K: Nitroaldol reaction of nitro[11C]methane to form 2-(hydroxymethyl)-2-nitro[2-11C]propane-1,3-diol and [11C]Tris. J. Label. Compd. Radiophram. 54: 140-144, 2011.
  31. Kato K*, Kikuchi T, Arai T, Nengaki N, Zhang MR: Tetrabutylammonium Fluoride Promoted α-[11C]Methylation of α-Arylesters: A Simple and Robust Method for the Preparation of 11C-labeled Ibuprofen. Tetrahedron Lett. 51: 5908-5911, 2010.
  32. Goměz-Vallejo V, Kato K, Oliden I, Calvo J, Baz Z, Borrell JI, Llop J*: Fully Automated Synthesis of 13N-labeled Nitrosothiols. Tetrahedron Lett. 51: 2990-2993, 2010.
  33. Kato K*, Zhang, MR, Suzuki K: Synthesis of (R, S)-[4-11C]Baclofen via Michael Addition of Nitromethane Labeled with Short-Lived 11C. Bioorg. Med. Chem. Lett. 19: 6222-6224, 2009
  34. Arai T*, Kato K, Zhang MR: The Synthesis of [carbonyl-11C]Acetophenone via the Stille Cross-Coupling Reaction of [11C]Acetyl Chloride with Tributylstannane Mediated by Pd2(dba)3/P(MeNCH2CH2)3N·HCl. Tetrahedron Lett. 50: 4788-4791, 2009.
  35. Kato K*, Zhang MR, Minegishi K, Suzuki K: Synthesis of 11C-labeled 2-Aminoethanol via a Nitroaldol Reaction Using Nitro[11C]methane. Bioorg. Med. Chem. Lett. 19: 3439-3441, 2009.
  36. Imamura K*, Onoe H, Shimazawa M, Nozaki S, Wada Y, Kato K, Nakajima H, Mizuma H, Onoe K, Taniguchi T, Sasaoka M, Hara H, Tanaka S, Araie M, Watanabe Y: Molecular imaging reveals unique degenerative changes in experimental glaucoma. Neuroreport 20: 139-144, 2009.
  37. Kumata K, Takei M, Ogawa M, Kato K, Suzuki K, Zhang MR*: One-pot synthesis of [13N]urea and [13N]carbamate using no-carrier added [13N]NH3. J. Label. Compd. Radiopharm. 52: 166-172, 2009.
  38. Goměz-Vallejo V, Kato K, Hanyu M, Minegishi K, Borrell JI, Llop J*: Efficient System for the Preparation of [13N]labeled Nitrosamines. Bioorg. Med. Chem. Lett. 19: 1913-1915, 2009.
  39. Arai T, Zhang MR*, Ogawa M, Fukumura T, Kato K, Suzuki K: Effificient and reproducible synthesis of [1-11C]acetyl chloride using the loop method. Appl. Radiat. Isot. 67: 296-300, 2009.
  40. Konno F, Arai T, Zhang MR*, Hatori A, Yanamoto K, Ogawa M, Ito T, Odawara C, Yamasaki T, Kato K, Suzuki K: Radiosyntheses of two positron emission tomography probes: [11C]Oseltamivir and its active metabolite [11C]Ro 64-0802. Bioorg. Med. Chem. Lett. 18: 1260-1263, 2008.
  41. Kato K*, Gustavsson SÅ, Långström B*: Asymmetric nitroaldol reaction using nitromethane labeled with 11C. Tetrahedron Lett. 49: 5837-5839, 2008.
  42. Kato K*, Zhang MR, Suzuki K: Rapid C-carboxylation of nitro[11C]methane for the synthesis of ethyl nitro[2-11C]acetate. Mol. BioSyst. 4: 53-55, 2008.
  43. Gustavsson SÅ, Kato K, Långström B*: Purification of [11C]nitromethane for use in asymmetric nitroadol reactions. J. Label. Compd. Radiopharm. 46: 1279-1285, 2003.
  44. Suzuki M*, Doi H, Kato K, Björkman M, Långström B, Watanabe Y, Noyori R*: Rapid Methylation for the Synthesis of a 11C-Labeled Tolylisocarbacyclin Imaging the IP2 Receptor in a Living Human Brain. Tetrahedron 56: 8263-8273, 2000.
  45. Watanabe Y, Matsumura K, Takechi H, Kato K, Morii H, Björkman M, Långström B, Noyori R, Suzuki M, Watanabe Y*: A Novel Subtype of Prostacyclin Receptor in the Central Nervous System. J. Neurochem. 72: 2583-2592, 1999.
  46. Satoh T, Ishikawa Y, Kataoka Y, Cui Y, Yanase H, Kato K, Watanabe Y, Nakadate K, Matsumura K, Hatanaka H, Kataoka K, Noyori R, Suzuki M, Watanabe Y*: CNS-specific prostacyclin ligands as neuronal survival-promoting factors in the brain. Eur. J. Neurosci. 11: 3115-3124, 1999.
  47. Suzuki M*, Kato K, Watanabe Y, Satoh T, Matsumura K, Watanabe Y, Noyori R*: 15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: a simple TIC derivative with potent anti-apoptotic activity for neuronal cells. Chem. Commun.: 307-308, 1999.
  48. Björkman M, Andersson Y, Doi H, Kato K, Suzuki M, Noyori R, Watanabe Y, Långström B*: Synthesis of 11C/13C Labelled Prostacyclines. Acta Chem. Scand. 52: 635-640, 1998.
  49. Takechi H, Matsumura K, Watanabe Y, Kato K, Noyori R, Suzuki M, Watanabe Y*: A Novel Subtype of the Prostacyclin Receptor Expressed in the Central Nervous System. J. Biol. Chem. 271: 5901-5906, 1996
  50. Suzuki M*, Kato K, Noyori R, Watanabe Y, Takechi H, Matsumura, K, Långström B, Watanabe Y: (15R)-16-m-Tolyl-17,18,19,20-tetranorisocarbacyclin: A stable Ligand with High Biding Affinity and Selectivity for a Prostacyclin Receptor in the Central Nervous System. Angew. Chem. Int. Ed. 35: 334-336, 1996.

総説等

  1. 宿里充穂，加藤孝一，花川隆：多発性硬化症のPET診断．ＰＥＴジャーナル32-34, 2015.
  2. 加藤孝一，宿里充穂，太田深秀，今林悦子，森下信一，横山淳，花川隆，本田学，松田博史：国立精神・神経医療研究センター脳病態統合イメージングセンターにおけるＰＥＴイメージング研究の取り組み．ＰＥＴジャーナル4-6, 2014.
  3. 菊池達矢，加藤孝一：放射線を利用した分子イメージング．化学と教育　59: 306-309, 2011.
  4. 菊池達矢，加藤孝一：分子プローブで読み解くＰＥＴイメージング．化学と教育　59: 310-313, 2011.
  5. 鈴木正昭，土居久志，加藤孝一：陽電子放射断層画像撮影法（ＰＥＴ）によるヒト脳機能分析のための高次プロスタグランジン（ＰＧ）プローブの創製．ファルマシア　37: 994-998, 2001.

著書

  1. Miller PW, Kato K, Långström B: The Chemistry of Molecular Imaging, Long N, Wong WT eds: Chapter 4 Carbon-11, Nitrogen-13, and Oxygen-15 Chemistry: An Introduction to Chemistry with Short-lived Radioisotopes, pp. 79-103 , 2014 12, John Wiley & Sons Inc

学会発表

シンポジウム

  1. 加藤孝一：ミエリンイメージングに向けたPETトレーサー開発の試み：第１８回日本脳神経核医学研究会：2017, 横浜
  2. 加藤孝一：ＢＢＢ透過性のイメージング：ＰＥＴサマーセミナー２０１３：2013, 金沢
  3. 19th International Symposium on Radiopharmaceutical Sciences：Presymposium workshop：C-11 Chemistry：C-C coupling reactions：2011, Amsterdam, Netherland

招待講演

  1. 2009年8月25日 CIC biomGUNE、San Sebastian、Spain
    New approaches for 11C-C bond forming methodology
  2. 2013年12月16日 放射線医学総合研究所、千葉
    Development of 11C-Labeling Methodology for PET Tracer Exploration
  3. 2016年11月28日 東京農工大学、東京
    アミノ酸トレーサーの合成と開発

競争的研究費獲得状況

研究代表者

  1. 基盤研究（C）（H23～H25）
    四級アルキルアンモニウムフルオリド類に促進される[11C]メチル化反応の開発トイメージングへの応用
  2. 基盤研究（C）（H28～H30）
    標識アミノ酸の設計・合成－新規アミノ酸PETトレーサーの開発
  3. 新学術領域研究（公募研究）（H29～H30）
    髄鞘化を特異的にイメージングするPETトレーサーの開発
  4. 基盤研究（C）（R1～R3）
    ミクログリアの活動を画像化するPETトレーサーの開発
  5. 基盤研究（B）（R3～R7）
    アルツハイマー病の超早期診断に向けたマルチバレントPETトレーサーの開発

研究分担者

  1. 中富健康科学（H22、代表：菊池達矢）
    研究課題名「ポジトロン断層撮像によるイブプロフェンの作用機序および体内動態の検討」
  2. 基盤研究（C）（H24～H26、代表：辻厚至）
    新しい実用的な腫瘍PETプローブの開発：C-11標識アミノイソ酪酸及びその類縁体
  3. 挑戦的萌芽（H26～H27、代表：高野浩司）
    悪性神経膠腫に対する、蛍光・PET dual tracerの開発
  4. 基盤研究（C）（H27、代表：松田博史）
    ミエリン特異的PETイメージング技術の確立に関する研究
  5. 基盤研究（C）（H27～H29、代表：宿里充穂）
    神経保護性ミクログリア特異的PETイメージング剤の開発
  6. 基盤研究（C）（H27～H29、代表：辻厚至）
    放射線照射後早期のPETトレーサー一過性の腫瘍集積亢進の分子メカニズムの解明
  7. 挑戦的研究（萌芽）（H30～H32、代表：小幡英章）
    PETによる脳脊髄ミクログリアイメージングによって慢性痛を可視化する研究
  8. 革新的技術による脳機能ネットワークの全容解明プロジェクト（R1～R5、代表：関和彦）
    認知症モデルマーモセットの産出と評価
  9. 基盤研究（C）（R3～R5、代表　小幡英章）
    中脳辺縁ドパミン神経系の鎮痛機序とその可塑性に関する研究
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