論文

Publications

国内の論文一覧はこちら

国際原著論文

2025年

  1. Andoh M, Shinoda N, Taira Y, Araki T, Kasahara Y, Takeuchi H, Miura M, Ikegaya Y, Koyama R*. Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia. Nat Commun., 16:918, 2025. DOI: 10.1038/s41467-025-56342-7

2024年

  1. Yoshida F, Nagatomo R, Utsunomiya S, Kimura M, Shun S, Kono R, Kato Y, Nao Y, Maeda K, Koyama R, Ikegaya Y, Lichtenthaler SF, Takatori S, Takemoto H, Ogawa K, Ito G, Tomita T*. Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons. Transl Psychiatry, 14:448, 2024. DOI: 10.1038/s41398-024-03167-5
  2. Maeda K, Tanimura M, Masago Y, Horiyama T, Takemoto H, Sasaki T, Koyama R, Ikegaya Y, Ogawa K*. Development of an in vitro compound screening system that replicate the in vivo spine phenotype of idiopathic ASD model mice. Front Pharmacol, 15:1455812, 2024. DOI: 10.3389/fphar.2024.1455812
  3. Araki T, Hiragi T, Kuga N, Luo C, Andoh M, Sugao K, Nagata H, Sasaki T, Ikegaya Y, Koyama R*. Microglia induce auditory dysfunction after status epilepticus in mice. Glia, 72:274-288, 2024. DOI: 10.1002/glia.24472

2022年

  1. Yu Z*, Sakai M, Fukushima H, Ono C, Kikuchi Y, Koyama R, Matsui K, Furuyashiki T, Kida S, Tomita H. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain Res Bull, 189:57-68, 2022. DOI: 10.1016/j.brainresbull.2022.08.017
  2. Ogaki A, Ikegaya Y, Koyama R*. Replacement of mouse microglia with human-derived induced pluripotent stem cell (hiPSC)-derived microglia in mouse organotypic slice cultures. Frontiers in Cellular Neuroscience, 16:918442, 2022. DOI: 10.3389/fncel.2022.918442
  3. Miyata H, Toyoda Y, Takada T, Hiragi T, Kubota Y, Shigesawa R, Koyama R, Ikegaya Y, Suzuki H*. Identification of an exporter that regulates vitamin C supply from blood to the brain. iScience, 25:103642, 2022. DOI: 10.1016/j.isci.2021.103642

2021年

  1. Hoshi Y, Shibasaki K, Gailley P, Ikegaya Y, Koyama R*. Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment. Science Advances, 7, eabj8080, 2021. DOI: 10.1126/sciadv.abj8080
  2. Zhou Z, Okamoto K, Onodera J, Hiragi T, Andoh M, Ikawa M, Tanaka KF, Ikegaya Y, Koyama R*. Astrocytic cAMP modulates memory via synaptic plasticity. PNAS, 118, e2016584118, 2021. DOI: 10.1073/pnas.2016584118
  3. Abe Y, Kwon S, Oishi M, Unekawa M, Takata N, Seki F, Koyama R, Abe M, Sakimura K, Masamoto K, Tomita Y, Okano H, Mushiake H, Tanaka KF*. Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice. Cell Reports, 36:109427, 2021. DOI: 10.1016/j.celrep.2021.109427
  4. Okada M, Kono R, Sato Y, Kobayashi C, Koyama R, Ikegaya Y*. Highly active neurons emerging in vitro. J Neurophysiol, 125:1322-1329, 2021. DOI: 10.1152/jn.00663.2020

2020年

  1. Onodera J, Nagata H, Nakashima A, Ikegaya Y, Koyama R*. Neuronal brain-derived neurotrophic factor manipulates microglial dynamics. Glia, 69:890-904, 2020. DOI: 10.1002/glia.23934
  2. Ogaki A, Araki T, Ichikawa M, Ikegaya Y, Koyama R*. A live imaging-friendly slice culture method using collagen membranes. Neuropsychopharmacology Reports, 40:307-313, 2020. DOI: 10.1002/npr2.12128

2019年

  1. Araki T, Ikegaya Y, Koyama R*. Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. Neuropsychopharmacology Reports, 40:85-91, 2019. DOI: 10.1002/npr2.12086
  2. Andoh M, Shibata K, Okamoto K, Onodera J, Morishita K, Miura Y, Ikegaya Y, Koyama R*. Exercise reverses behavioral and synaptic abnormalities after maternal inflammation. Cell Reports, 27:2817-2825, 2019. DOI: 10.1016/j.celrep.2019.05.015
  3. Kono R, Kim GL, Nagata H, Ikegaya Y, Koyama R*. Induced neuronal activity does not attenuate amyloid beta-induced synaptic loss in vitro. Neuropsychopharmacology Reports, 39:306-311, 2019. DOI: 10.1002/npr2.12074
  4. Orita K, Sawada K, Koyama R, Ikegaya Y*. Deep learning-based quality control of cultured human-induced pluripotent stem cell-derived cardiomyocytes. Journal of Pharmacological Sciences, 140:313-316, 2019. DOI: 10.1016/j.jphs.2019.04.008
  5. Kasahara Y, Igata H, Sasaki T, Ikegaya Y, Koyama R*. The pharmacological assessment of GABAA receptor activation in experimental febrile seizures in mice. eNeuro, 6:1, 2019. DOI: 10.1523/ENEURO.0429-18.2019

2018年

  1. Hoshi Y, Okabe K, Shibasaki K, Funatsu T, Matsuki N, Ikegaya Y, Koyama R*. Ischemic brain injury leads to brain edema via hyperthermia-induced TRPV4 activation. Journal of Neuroscience, 38:5700-5709, 2018. DOI: 10.1523/JNEUROSCI.2888-17.2018

2017年

  1. Hiragi T, Andoh M, Araki T, Shirakawa T, Ono T, Koyama R*, Ikegaya Y. Differentiation of human induced pluripotent stem cell (hiPSC)-derived neurons in mouse hippocampal slice cultures. Frontiers in Cellular Neuroscience, 11:143, 2017. DOI: 10.3389/fncel.2017.00143

2016年

  1. Luo C, Koyama R (Co-first)*, Ikegaya Y. Microglia engulf viable newborn cells in the epileptic dentate gyrus. Glia, 64:1508-1517, 2016. DOI: 10.1002/glia.23018
  2. Andoh M, Koyama R (Co-first)*, Ikegaya Y. Severity of kainic acid-induced seizures is not aggravated in the maternal immune activation mouse model of gestational poly(I:C) exposure. Journal of Autism and Epilepsy, 1:1013, 2016. ☆
  3. Kasahara Y, Koyama R (Co-first)*, Ikegaya Y. Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures. Neuroscience Research, 111:64-69, 2016. DOI: 10.1016/j.neures.2016.05.001
  4. Mikami Y, Kanemaru K, Okubo Y, Nakaune T, Suzuki J, Shibata K, Sugiyama H, Koyama R, Murayama T, Ito A, Yamazawa T, Ikegaya Y, Sakurai T, Saito N, Kakizawa S, Iino M*. Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death. EBioMedicine, 16:30369-30373, 2016. DOI: 10.1016/j.ebiom.2016.08.020
  5. Ohki M, Sugiyama K, Kawaia F, Tanaka H, Nihei Y, Unzai S, Takebe M, Matsunaga S, Adachi S, Shibayama N, Zhou Z, Koyama R, Ikegaya Y, Takahashi T, Jeremy R.H. Tame RH J, Iseki M, Park S*. Structural basis for photoactivation of a light-regulated adenylate cyclase from the photosynthetic cyanobacterium Oscillatoria acuminatea. PNAS, 113:6659-6664, 2016. DOI: 10.1073/pnas.1517520113
  6. Tao K, Ichikawa J, Matsuki N, Ikegaya Y, Koyama R*. Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice. Neuroscience, 318:34-44, 2016. DOI: 10.1016/j.neuroscience.2016.01.011
  7. Zhou Z, Tanaka KF, Matsunaga S, Iseki M, Watanabe M, Matsuki N, Ikegaya Y, Koyama R*. Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis. Scientific Reports, 5:19679, 2016. DOI: 10.1038/srep19679
  8. Sajo M, Sugiyama H, Yamamoto H, Tanii T, Matsuki N, Ikegaya Y, Koyama R*. Neuraminidase-Dependent Degradation of Polysialic Acid Is Required for the Lamination of Newly Generated Neurons. PLoS One, 11:e0146398, 2016 DOI: 10.1371/journal.pone.0146398.

2014年

  1. Tao K, Matsuki N, Koyama R*. AMP-Activated Protein Kinase (AMPK) mediates activity-dependent axon branching by recruiting mitochondria to axon. Developmental Neurobiology, 74:557-573, 2014. DOI: 10.1002/dneu.22149

2013年

  1. Shibata K, Nakahara S, Shimizu E, Yamashita T, Matsuki N, Koyama R*. Repulsive guidance molecule a (RGMa) regulates hippocampal mossy fiber branching in vitro. Neuroreport, 24:609-615, 2013. DOI: 10.1097/WNR.0b013e3283632c08

2012年

  1. Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens B*. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron, 74:691-705, 2012. DOI: 10.1016/j.neuron.2012.03.026
  2. Koyama R*, Tao K, Sasaki T, Ichikawa J, Miyamoto D, Muramatsu R, Matsuki N, Ikegaya Y. GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy. Nature Medicine, 18:1271-1278, 2012. DOI: 10.1038/nm.2850
  3. Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Matsuki N, Koyama R, Tomita T*, Iwatsubo T. Activity-dependent proteolytic cleavage of Neuroligin-1. Neuron, 76:410-422, 2012. DOI: 10.1016/j.neuron.2012.10.003

2011年

  1. Tamura M, Sajo M, Kakita A, Matsuki N, Koyama R*. Prenatal stress inhibits neuronal maturation through downregulation of mineralocorticoid receptors. Journal of Neuroscience, 31:11505-11514, 2011. DOI: 10.1523/JNEUROSCI.3447-10.2011

2010年

  1. Muramatsu R, Nakahara S, Ichikawa J, Watanabe K, Matsuki N, Koyama R*. The ratio of 'deleted in colorectal cancer' to' uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality. Brain, 133:60-75, 2010. DOI: 10.1093/brain/awp266

2009年

  1. Nakahara S, Tamura M, Matsuki N, Koyama R*. Neuronal hyperactivity sustains the basal dendrites of immature dentate granule cells: Time-lapse confocal analysis using hippocampal slice cultures. Hippocampus, 19:379-391, 2009. DOI: 10.1002/hipo.20529
  2. Tamura M, Tamura N, Ikeda T, Koyama R, Ikegaya Y, Matsuki N, Yamada MK*. Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers. Molecular Brain, 2:2, 2009. DOI: 10.1186/1756-6606-2-2

2008年

  1. Ohshima Y, Kubo T*, Koyama R, Ueno M, Nakagawa M, Yamashita T*. Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1α. Journal of Neuroscience, 28:8344-8353, 2008. DOI: 10.1523/JNEUROSCI.1670-08.2008
  2. Yamada RX, Sasaki T, Ichikawa J, Koyama R, Matsuki N, Ikegaya Y*. Long-range axonal calcium sweep induces axon retraction. Journal of Neuroscience, 28:4613-4618, 2008. DOI: 10.1523/JNEUROSCI.0019-08.2008
  3. Muramatsu R, Ikegaya Y, Matsuki N, Koyama R*. Early-life status epilepticus induces ectopic granule cells in adult mice dentate gyrus. Experimental Neurology, 211:503-510, 2008. DOI: 10.1016/j.expneurol.2008.02.026

2007年

  1. Muramatsu R, Ikegaya Y, Matsuki N, Koyama R*. Neonatally born granule cells numerically dominate adult mice dentate gyrus. Neuroscience, 148:593-598, 2007. DOI: 10.1016/j.neuroscience.2007.06.040
  2. Ichikawa J, Yamada RX, Muramatsu R, Ikegaya Y, Matsuki N, Koyama R*. Cryopreservation of granule cells from postnatal rat hippocampus. Journal of Pharmacological Science, 104:387-391, 2007. DOI: 10.1254/jphs.sc0070162
  3. Koyama R, Muramatsu R, Sasaki T, Kimura R, Ueyama C, Tamura M, Tamura N, Ichikawa J, Takahashi N, Usami A, Yamada MK, Matsuki N, Ikegaya Y*. A Low-Cost Method for Brain Slice Cultures. Journal of Pharmacological Science, 104:191-194, 2007. DOI: 10.1254/jphs.sc0070119

2006年

  1. Tamura M, Koyama R, Ikegaya Y, Matsuki N, Yamada MK*. K252a, an inhibitor of Trk, disturbs pathfinding of hippocampal mossy fibers. Neuroreport, 17:481-486, 2006. DOI: 10.1097/01.wnr.0000208997.23448.ea

2004年

  1. Koyama R, Yamada MK, Fujisawa S, Katoh-Semba R, Matsuki N, Ikegaya Y*. Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus. Journal of Neuroscience, 24:7215-7224, 2004. DOI: 10.1523/JNEUROSCI.2045-04.2004
  2. Koyama R, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y*. Developmental switch in axon guidance modes of hippocampal mossy fibers in vitro. Developmental Biology, 267:29-42, 2004. DOI: 10.1016/j.ydbio.2003.11.008
  3. Kim JA, Koyama R, Yamada RX, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y*. Environmental control of the survival and differentiation of dentate granule neurons. Cerebral Cortex, 14:1358-1364, 2004. DOI: 10.1093/cercor/bhh096

2002年

  1. Koyama R, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y*. Group II metabotropic glutamate receptor activation is required for normal hippocampal mossy fibre development in the rat. Journal of Physiology (London), 539:157-162, 2002. DOI: 10.1113/jphysiol.2001.013505
  2. Ikegaya Y*, Koyama R, Yamada MK, Nishiyama N, Matsuki N. Rapid regrowth of hippocampal mossy fibres and preceding maturation of NMDA receptor-mediated neurotransmission. European Journal of Neuroscience, 15:1859-1862, 2002. DOI: 10.1046/j.1460-9568.2002.02035.x

国際総説論文

2023年

  1. Andoh M, and Koyama R*. Microglia and GABA: Diverse functions of microglia beyond GABA-receiving cells. Neuroscience Res, 187:52-57, 2023. DOI: 10.1016/j.neures.2022.09.008

2022年

  1. Paolicelli RC*, Koyama R, et al. Microglia states and nomenclature: A field at its crossroads. Neuron, 22:3458-3483, 2022. DOI: 10.1016/j.neuron.2022.10.020

2021年

  1. Andoh M, and Koyama R*. Comparative review of microglia and monocytes in CNS phagocytosis. Cells, 10:2555, 2021. DOI: 10.3390/cells10102555
  2. Ogaki A, Ikegaya Y, and Koyama R*. Extracellular vesicles taken up by astrocytes. International Journal of Molecular Sciences, 22:10553, 2021. DOI: 10.3390/ijms221910553
  3. Kono R, Ikegaya Y, and Koyama R*. Phagocytic glial cells in brain homeostasis. Cells, 10:1348, 2021. DOI: 10.3390/cells10061348
  4. Andoh M, and Koyama R*. Assessing microglial dynamics by live imaging. Frontiers in Immunology, 12:617564, 2021. DOI: 10.3389/fimmu.2021.617564
  5. Andoh M, and Koyama R*. Microglia regulate synaptic development and plasticity. Developmental Neurobiology, 81:568-590, 2021. DOI: 10.1002/dneu.22814
  6. Kinoshita S, and Koyama R*. Pro- and anti-epileptic roles of microglia. Neural Regeneration Research, 16:1369-1371, 2021. DOI: 10.4103/1673-5374.300976
  7. Araki T, Ikegaya Y, and Koyama R*. The effects of microglia- and astrocyte-derived factors on neurogenesis in health and disease. European Journal of Neuroscience, 54:5880-5901, 2021. DOI: 10.1111/ejn.14969

2020年

  1. Andoh M, Ikegaya Y, and Koyama R*. Microglia modulate the structure and function of the hippocampus after early-life seizures. Journal of Pharmacological Sciences, 144:212-217, 2020. DOI: 10.1016/j.jphs.2020.09.003
  2. Andoh M and Koyama R*. Exercise, microglia, and beyond — workout to communicate with microglia. Neural Regeneration Research, 11:2029-2030, 2020. DOI: 10.4103/1673-5374.282241
  3. Ogaki A, Ikegaya Y, and Koyama R*. Vascular abnormalities and the role of vascular endothelial growth factor in the epileptic brain. Frontiers in Pharmacology, 11:20, 2020. DOI: 10.3389/fphar.2020.00020

2019年

  1. Andoh M, Ikegaya Y, and Koyama R*. Synaptic Pruning by Microglia in Epilepsy. Journal of Clinical Medicine, 8:2170, 2019. DOI: 10.3390/jcm8122170
  2. Zhou Z, Ikegaya Y, and Koyama R*. The astrocytic cAMP pathway in health and disease. International Journal of Molecular Sciences, 20:779, 2019. DOI: 10.3390/ijms20030779

2018年

  1. Koyama R* and Ikegaya Y. The molecular and cellular mechanisms of axon guidance in mossy fiber sprouting. Frontiers in Neurology, 9:382, 2018. DOI: 10.3389/fneur.2018.00382
  2. Kasahara Y, Ikegaya Y, and Koyama R*. Neonatal seizure models to study epileptogenesis. Frontiers in Pharmacology, 9:385, 2018. DOI: 10.3389/fphar.2018.00385
  3. Hiragi T, Ikegaya Y, and Koyama R*. Microglia after seizures and in epilepsy. Cells, 7:26, 2018. DOI: 10.3390/cells7040026

2016年

  1. Luo C, Ikegaya Y, and Koyama R*. Microglia and neurogenesis in the epileptic dentate gyrus. Neurogenesis, 3, e1235525, 2016. DOI: 10.1080/23262133.2016.1235525
  2. Koyama R*. Dentate circuitry as a model to study epileptogenesis. Biological and Pharmaceutical Bulletin, 39:1-6, 2016. DOI: 10.1248/bpb.b16-00125

2015年

  1. Koyama R* and Ikegaya Y. Microglia in the pathogenesis of autism spectrum disorders. Neuroscience Research, 100:1-5, 2015. DOI: 10.1016/j.neures.2015.06.005

2013年

  1. Koyama R*. The use of organotypic slice cultures for the study of epileptogenesis. Neuropathology, 33:475-479, 2013. DOI: 10.1111/neup.12019

2010年

  1. Koyama R* and Matsuki N. Novel etiological and therapeutic strategies for neurodiseases: Mechanisms and consequences of febrile seizures: Lessons from animal models. Journal of Pharmacological Sciences, 113:14-22, 2010. DOI: 10.1254/jphs.09r19fm

2005年

  1. Koyama R* and Ikegaya Y. To BDNF or not to BDNF, that is the epileptic hippocampus. Neuroscientist, 11:282-287, 2005. DOI: 10.1177/1073858405278266

2004年

  1. Koyama R and Ikegaya Y*. Mossy fiber sprouting as a potential therapeutic target for epilepsy. Current Neurovascular Research, 1:3-10, 2004. DOI: 10.2174/1567202043480242

著書（洋書）

2020年

  1. Andoh M, Ikegaya Y, and Koyama R*. Microglia in animal models of autism spectrum disorders. Prog Mol Biol Transl Sci, 173:239-273, 2020.

2019年

  1. Andoh M, Ikegaya Y, and Koyama R*. Microglia as possible therapeutic targets for autism spectrum disorders. Prog Mol Biol Transl Sci, 167:223-245, 2019.

2017年

  1. Koyama R*. Experimental febrile seizures in rodents. In P.M. Conn (Ed.), Animal Models for the Study of Human Disease, 2nd edition (pp. 755-768). Elsevier, 2017.

2013年

  1. Koyama R*. Animal models of febrile seizures. In P.M. Conn (Ed.), Animal Models for the Study of Human Disease (pp. 889-901). Elsevier, 2013.